Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"BCG vaccine"”.
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Novel Mechanisms of Antigen Processing That Enhance Bcg Vaccine Efficacy
… year. The World Health Organization recommends a vaccine as the best option to prevent this disease. The current vaccine, BCG, has a variable efficacy and does not protect adults. It is known that BCG vaccine becomes sequestered in special phagosome compartments of macrophages that do not fuse …
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Induction of Stronger and Long Lasting Vaccine Immunity to Tuberculosis
… cause of death due to an infection in mankind. BCG vaccine protects against childhood tuberculosis although, it fails to protect against adult tuberculosis. BCG vaccine localizes to immature phagosomes of macrophages, and avoids lysosomal fusion, which decreases peptide antigen production. …
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Possible associations between incidence of tuberculosis in Varna region and from the effects of BCG vaccine // Възможни асоциации между заболеваемостта от туберкулоза в регион Варна и ефекта от приложената BCG ваксина
… на туберкулоза и въпреки задължителната BCG имунизация се наблюдава бавно нарастване на заболяемостта от туберкулоза при децата. Разпространението и честотата на заболяването са тясно свързани с инфектираността и имунологичния статус на населението в даден район. Настоящият труд акцентира …
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Growth of luciferase-transfected BCG in whole blood : use of a novel assay to study immune responses to mycobacteria in children
The existing Bacille Calmette-Guerin (BCG) vaccine offers some protection against TB, but its efficacy varies for unknown reasons. In order to develop an effective vaccine, a comprehensive understanding of protective immunity in adults and children is needed. Studies involving host-pathogen …
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Optimisation of a flow cytometry antibody panel to detect BCG-induced innate responses in infants
… (HIV) and previous Bacillus Calmette–Guérin (BCG) vaccination. As it stands, other than inborn errors in key mycobacterial susceptibility genes both animal and human studies have not found many genetic polymorphisms that are strongly and reproducibly associated with increased mycobacterial …
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Modelling Multivariate Nonlinear Vaccine Induced Immune Responses
Interpretable statistical models for multivariate vaccine induced immune response data are important as they provide a rigorous means of deciding which vaccine candidates should be advanced in the clinical trials process. We consider applications of several different statistical models to a vaccine …
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Human Inborn Errors of Immunity: Tuberculosis, Autoimmunity, and Beyond
… in human history. Bacillus Calmette-Guérin (BCG) vaccine, first implemented medically in 1921, has remained the only available vaccine for TB, although its protective effect is moderate. TB occurs in 5-10% of individuals exposed to those pathogens, while 90-95% remain asymptomatic …
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BCG-specific T cell proliferation and cytotoxic capacity in infants as risk of tuberculosis disease, following newborn BCG vaccination
BCG is the only vaccine against tuberculosis and has been used for over 90 years. BCG efficacy is variable, especially in countries with high TB prevalence, where over a million deaths due to tuberculosis, are still reported annually. New TB vaccines are under development to either replace or boost …
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The relationship between immunization and food allergy and sensitisation in South African children
… or exposure to the virus or microbe in the vaccine may decrease the risk for allergy. Previous studies have shown that the effect of vaccinations on food allergy and food sensitisation varies. Therefore, the aim of this study is to determine if a relationship exists between vaccinations and …
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Development and testing of recombinant B. abortus RB51 vaccine strains carrying M. tuberculosis protective antigens
… people develop TB. Bacille Calmette-Guérin (BCG), an attenuated strain of M. bovis, is the only licensed TB vaccine in the world. Clinical studies have shown childhood vaccination with BCG to be protective against disseminating and meningeal forms of TB. However, the efficacy of BCG against …
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Cost-effectiveness analysis of MVA85 vaccine: a new TB vaccine candidate
… (TB) remains a major public health concern. The BCG vaccine is, currently, the only vaccine against TB and, although it provides some protection against disseminated forms of TB, its effectiveness in preventing primary infection and disease progression to pulmonary TB is highly varied. A number …
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The impact of malaria on the immunogenicity and efficacy of mycobacterium bovis BCG vaccination against mycobacterium tuberculosis in mice
Background Bacillus Calmette-Guerin (BCG) remains the only licensed vaccine for use against tuberculosis (TB), however, it is poorly efficacious against pulmonary TB in adults. The poor efficacy has been attributed in part to coinfections with many other unrelated pathogens that overlap …
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Involvement of endothelial cells and macrophages in mycobacterial infections
… of death worldwide. This is in spite of the BCG vaccine against tuberculosis that has been in use for over 80 years as well as several chemotherapies. Mycobacterium tuberculosis, the causative agent of tuberculosis, is a facultative intracellular pathogen targeting host cells, predominantly …
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Producción de Intermediarios Reactivos de Nitrógeno en cultivo de células mononucleares de cabras expuestas al BCG de M. bovis, suplementadas con 1,25 Dihidroxivitamina D3
… exposición a la vacuna bacilo Calmette-Guérin (BCG) de M. bovis altera la respuesta inmune específica, causando un incremento de la respuesta inmune mediada por células Th1 y una estimulación de la respuesta inmune Th2. Se ha planteado que el principio activo de la vitamina D, la 1,25 …