Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 41 for “"BCAA"”.
-
Differential BCAA Metabolism in Tissues of Tumor-Bearing Mice: A Path to Understanding Cancer Cachexia
… support. While branched-chain amino acids (BCAAs) stimulate muscle protein synthesis, BCAA-targeted therapies have shown inconsistent results. In this study, a C26 colon cancer mouse model was used to examine how tumor burden alters BCAA metabolism across skeletal muscle, liver, kidney, and …
-
The Effect of a Bcaa Supplement with and without Cho on Performance in Recreationally Trained Cyclists
… the effect of a branched- chain amino acid (BCAA) supplement with and without carbohydrate (CHO) on performance in competitive cyclists. Subjects were recruited from the GSU cycling team (n=6). Each subject's maximal oxygen uptake (VO2 max) was determined on an electrically braked cycle …
-
Mapping And Directing Branched-Chain Amino Acid Metabolism In Health And Insulin Resistance
… identified changes in branched-chain amino acid (BCAA) levels as biomarkers of diabetes, heart failure, and some forms of cancer. However, the changes in BCAA metabolism in each of these cases, and even in the normal state, have remained elusive. Using novel heavy-isotope infusions, I quantified …
-
Branched-Chain Amino Acid Metabolism in the Neonatal Pig
Branched-chain amino acids (BCAA) are a group of essential amino acids consisting of leucine, isoleucine, and valine. Leucine, in particular, has signaling functions affecting protein and energy metabolism. Plasma leucine concentration is positively correlated with obesity and associated metabolic …
-
The effect of branched-chain amino acid ingestion on physical performance during prolonged exercise
… tryptophan (TRP) to branched-chain amino acid (BCAA) concentrations may mediate an increase in cerebral serotonin synthesis, through an increased cerebral tryptophan uptake. It is postulated that the increased brain serotonin content may induce central fatigue during prolonged exercise. Until …
-
Defective branched chain amino acid catabolism impairs exercise capacity and glucose homeostasis in the mouse
The branched-chain amino acids (BCAAs) leucine, isoleucine and valine, play a central role in substrate metabolism, energetics, and protein synthesis. Although BCAA supplementation is widely used to improve exercise capacity and physical fitness, elevated levels of the BCAAs have been implicated in …
-
A PROTEIN IN SEARCH OF FUNCTION: NIPSNAP1 IN MITOCHONDRIAL BRANCHED-CHAIN AMINO ACID METABOLON, BRAIN AND APOPTOSIS
… first two enzymes in branched-chain amino acid (BCAA) catabolism, the mitochondrial branched-chain aminotransferase (BCATm) and the branched-chain α-keto-acid dehydrogenase complex (BCKDC). Dysregulation of BCAA metabolism results in neurologic dysfunction. Studies in brains of phenylketonuria …
-
The Effect of Age and Sex on Chemotherapy-Induced Cachexia and Branched-Chain Amino Acid Metabolism
… supplements like the branched-chain amino acids (BCAA) in reversing cachexia remains limited and inconsistent. However, researchers typically prioritize tumour BCAA metabolism and overlook these amino acids in the skeletal muscle. In addition, studies investigating chemotherapy-induced cachexia …
-
The role of adiposity in the association of branched-chain amino acids and metabolic and clinical markers in healthy adults on controlled diets.
Branched-chain amino acids (BCAAs) leucine, isoleucine, and valine have been positively associated with adiposity and insulin resistance. Targeted metabolomic data from plasma samples of healthy adults (n=40 men, n=40 women) aged 18-45 years old derived from a randomized crossover feeding trial …
-
Protein metabolism in the lactating sow
… plasma tryptophan to branched-chain amino acid (BCAA) ratio. High plasma tryptophan to the branched chain amino acids is associated with increased tryptophan entry in the brain and serotonin secretion which in turn is involved in the depression of feed intake in other species. The effect of …
-
Factors influencing ammonia metabolism during prolonged exercise in man
… ingestion and (3) branched-chain amino acid (BCAA) feeding. A total of 25 subjects participated in these three studies. The first study utilised active, untrained subjects who cycled at approximately 38 and 70% peak oxygen consumption (V02peak) for 40 min. These workrates represented low …
-
Chronic Dietary Supplementation of Branched-Chain Amino Acids Does Not Attenuate Muscle Torque Loss in a Mouse Model of Duchenne Muscular Dystrophy
… a control or elevated branched chain amino acid (BCAA) diet nocturnally for 25 weeks to determine if the elevated BCAAs would attenuate muscle torque loss. Twenty-five weeks of chronic, elevated BCAA supplementation had no impact on muscle function measures. Interestingly, mdx and WT animals had …
-
Regulatory Roles of Essential Amino Acids, Energy, and Insulin in Mammary Cell Protein Synthesis
… investigate whether branched chain amino acids (BCAA): leucine , isoleucine , and valine , become limiting for milk protein synthesis when Met and Lys supply were not limiting, and 3) to develop a mathematical representation for the EAA and insulin effects on cellular signals for protein …
-
Excess leucine in diets for growing pigs negatively affects growth performance, nitrogen balance, and metabolism of branched-chain amino acids and tryptophan
… Leu on metabolism of branched-chain amino acids (BCAA) and to demonstrate the interactions among BCAA and Trp in diets fed to growing pigs. In experiment 1, the objective was to determine the effects of excess dietary Leu on growth performance, N balance, protein retention, and serotonin synthesis …
-
ΜΕΤΑΒΟΛΙΣΜΟΣ ΤΟΥ ΑΖΩΤΟΥ ΤΗΣ ΛΕΥΚΙΝΗΣ ΣΤΟ ΦΛΟΙΟ ΕΓΚΕΦΑΛΟΥ ΕΠΙΜΥΟΣ. ΠΕΙΡΑΜΑΤΑ ΜΕ 15Ν
… A METABOLIC COMPARTMENTALIZATION OF THE THREE BCAA, IN RAT BRAIN CORTEX, IS SUGGESTED.
-
Whole body metabolic alterations as an early event in Kras-Driven cancers
… plasma levels of the branched chain amino acids (BCAAs), leucine, isoleucine and valine, and showed these elevations occurred concomitantly with early invasive cancer. Further experiments in mouse models revealed that increased turnover of peripheral protein stores drove these changes in a pattern …
-
Understanding the Aetiology of Metabolic Diseases and Related Phenotypes through Human Genetics
… circulating level of branched-chain amino acids (BCAA) – that are essential nutrients in human health – could be potentially a modifiable target for improving metabolic health. Through a bidirectional MR analysis, I showed that genetically predicted higher level of circulating BCAA causally …
-
The Influence of Heat Stress on Milk Yield, Gastrointestinal Permeability, and Nutrient Partitioning in Lactating Dairy Cattle
… of assessing branched-chain amino acid (BCAA) requirements during HS. BCAA are oxidized for ATP synthesis in extrahepatic tissues and provide precursors for the biosynthesis of non-essential amino acids. They are also taken up by the mammary gland at a rate greater than what they are used …
-
Leucine and exercise improve skeletal muscle function in the mdx mouse
… that leucine, a branched chain amino acid (BCAA) with anabolic properties, given to sedentary and exercised x-linked dystrophic mice (mdx) over 4 weeks would improve skeletal muscle function and decrease markers of skeletal muscle degradation. In sedentary mdx mice, leucine improved tetanic …
-
Muscle Growth and Development in Intrauterine Growth Restricted Pigs
… investigate whether branched-chain amino acids (BCAA) are able to enhance protein synthesis in intrauterine growth restricted (IUGR) pig muscle. Newborn piglets were considered normal body weight (NBWT) or IUGR when birth weight was within ± 0.5 SD and -2 SD of litter average respectively. Muscle …
Page 1 of 3