Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 214 for “"BBB"”.
-
Identification and Characterization of Sex-Specific Transcripts in the Blood-Brain Barrier of Drosophila melanogaster
… We have evidence that the Blood-Brain Barrier (bbb) plays an important role in this communication. Specific feminization of the bbb in otherwise normal males severely reduces their courtship. This suggests that male specific factors in the bbb play an important role in mating behavior. To …
-
Genetic and Chemical Dissection of BloodBrain Barrier Development in Zebrafish
<p>The blood-brain barrier (BBB) maintains a homeostatic environment as well as prohibits the entrance of xenobiotics into the brain. Because of these qualities, drug delivery is a fundamental challenge for the treatment of many diseases of the central nervous system (CNS). Along with limiting the …
-
The Physical Mechanism of Blood-Brain Barrier Opening Using Focused Ultrasound and Microbubbles
… in the safe opening of the blood-brain barrier (BBB), a specialized structure that impedes the delivery of therapeutic agents to the parenchyma. Despite the fact that several approaches have been successful in overcoming the BBB impermeability, none of them can induce localized BBB opening …
-
Generation and Characterization of Human Blood-Brain Barrier Models for Investigating Neuropsychiatric Disorders and Tumor Metastasis
<p>The blood–brain barrier (BBB) is important in the normal function of the central nervous system (CNS). An altered BBB has been described in various neuropsychiatric disorders. The brain-specific microvascular endothelial cell (BMEC) is an essential structural component of the BBB. To test if …
-
Uncovering astrocyte roles at the blood brain barrier in the healthy and concussed brain
The blood-brain barrier (BBB) is regulated by factors that can be secreted by multiple cell types, including astrocytes, that maintain the BBB in health and promote repair after injury. However, astrocyte contributions to the BBB are largely assumed from transplantation studies in which astrocyte …
-
Enhanced Delivery of Gold Nanoparticles with Therapeutic Potential for Targeting Human Brain Tumors
The blood brain barrier (BBB) remains a major challenge to the advancement and application of systemic anti-cancer therapeutics into the central nervous system. The structural and physiological delivery constraints of the BBB significantly limit the effectiveness of conventional chemotherapy, …
-
Development and Characterization of an In-House Custom Bioreactor for the Cultivation of a Tissue Engineered Blood-Brain Barrier
… substantial problems is the blood-brain barrier (BBB). The BBB is the selective diffusion barrier between the circulating blood and the brain. The barrier’s main function is to maintain CNS homeostasis and protect the brain from the extracellular environment. The progression of BBB research has …
-
ORGANOIDS AS TOOLS TO STUDY BRAIN DEVELOPMENT AND DISEASE
… system composed by the Blood Brain Barrier (BBB) and ORG. The in vitro BBB is composed by human brain microvascular endothelial cells (HBMEC) and human astrocytes (HA). ORG are generated from induced pluripotent stem cells (iPSCs) cultured with different differentiation media for 36 days, and …
-
Development of a physiologically accurate 3D blood-brain barrier hydrogel model
The blood-brain barrier (BBB) is a tightly interconnected network of cells that creates a semi-permeable barrier between the central nervous system and the rest of the human body, taking in nutrients and blocking/excreting waste/potentially toxic chemicals from the brain, maintaining the brain's …
-
A Single Cell and Spatial Transcriptomic Investigation of Traumatic Brain Injury: Novel insights into endothelial-derived Eph signaling
… outcome is the extent of blood-brain barrier (BBB) disruption, which under normal conditions prevents the passage of bacteria, neurotoxins, and macromolecules from entering the brain. Disruption of the BBB is linked to worse clinical outcomes in patients in both the acute, subacute, and chronic …
-
Modulation of Brain Tissue Transport and Endothelial Glycocalyx and Tight Junctions of the Blood-Brain Barrier by Transcranial Direct Current Stimulation
… the permeability (P) of the blood-brain barrier (BBB), the interface between blood circulation and brain tissue. Brain extracellular space (ECS) is a narrow microenvironment which surrounds every cell in the central nervous system (CNS). ECS occupies ~20% of brain tissue and contains interstitial …
-
A Framework for Building Back Better during Post-Disaster Reconstruction and Recovery
… efforts. The slogan ―Build Back Better‖ (BBB) denotes improving the physical, psycho-social and economic aspects of communities during reconstruction and recovery to induce greater resilience. This research project has been designed to understand what ―Building Back Better‖ entails; the …
-
MOLECULAR PHYSIOLOGY OF BLOOD-BRAIN BARRIER TIGHT JUNCTIONS
… molecular interface of the blood-brain barrier (BBB) is a highly selective physiological barrier. The BBB shields the central nervous system (CNS) for harmful agents while also preventing lifesaving drugs from entering the CNS. With the prevalence of neurogenerative disease on the rise, there is …
-
The Role of Astrocyte-Derived Factors in the Regulation of Multidrug Resistance at the Developing Blood-Brain Barrier
… encoded by Abcb1) at the blood-brain barrier (BBB) plays an important role in regulating the movement of exogenous and endogenous substrates into the developing brain. P-gp levels in brain endothelial cells (BECs), which form the capillaries of the BBB, increase dramatically in late gestation …
-
Molecular Mechanisms Involved in Escherichia coli K1 and Haemophilus influenzae Type a Blood-Brain Barrier Impairment
Blood Brain Barrier (BBB) is a protective barrier against possible neurotoxic molecules, such as proteins or endogenous metabolites, xenobiotics derived from the environment or ingested with the food. At the same time, BBB selectively allows the cross of ions and nutrients from blood into the CNS …
-
Neurotoxic effects of malathion and lead acetate on the blood-brain barrier: Disruptive effects caused by different mechanisms examined with an in vitro blood-brain barrier system
… system, but also on the blood-brain barrier (BBB). The BBB consists of specialized endothelial cells that form the vasculature of the brain; it regulates passage of nutrients, while preventing potentially damaging substances from entering the brain. The main feature of the BBB is the presence …
-
Brain microvascular endothelial cell dysfunction in schizophrenia: a preliminary report
Disruption of the blood-brain barrier (BBB) is hypothesized to play an important role in the disease biology of schizophrenia (SZ). Brain microvascular endothelial cells (BMECs) have paracellular and transcellular proteins, transporters, as well as important extracellular matrix proteins, which …
-
Advances in targeted chemotherapy using MRI-guided focused ultrasound to disrupt the blood-brain barrier
… unable to penetrate the blood-brain barrier (BBB). A novel approach to overcome this barrier uses focused ultrasound to induce localized BBB disruption in a targeted region of the brain and magnetic resonance imaging (MRI) to guide and monitor the procedure. The purpose of this thesis was to …
-
Development and Optimisation of Nanoparticulate System for Brain Delivery of L-DOPA
… the delivery of LD across blood-brain barrier (BBB). Nanoparticles (NPs) provide a feasible choice as drug delivery device to cross the BBB because it may overcome the biological barrier and increase the bioavailability of the drug in the brain. Methods: LD-loaded PLGA NPs were prepared using …
-
A Robot Operating System (ROS) based humanoid robot control
… Premium Humanoid Robot (BPHR). BeagleBone Black (BBB), the decision-making and implementing (intelligence providing) component, with multifunctional capabilities is used in this research. Robot operating System (ROS) and its libraries, as well as Python Script and its libraries have been developed …
Page 1 of 11