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Showing 1 to 2 of 2 for “"BB Rat"”.
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Genetic Loci Contributing to Spontaneous Autoimmune Diabetes
… type 1 diabetes (T1D) in the BioBreeding (BB) rat mimics human T1D as the rats experience weight loss, polydipsia, polyuria, ketoacidosis, onset during puberty and insulin-dependency within a day after diagnosis. Because the DP rat develops T1D spontaneously, it is a prime laboratory animal …
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Use of a conservation-of-linkage strategy to identify a candidate for the rat Lymphopenia gene
The rat Lymphopenia gene, Lyp, is absolutely required for the development of Insulin-Dependent Diabetes Mellitus (IDDM) in the BioBreeding (BB) rat. In order to overcome the lack of positional cloning resources available in the rat to clone the Lyp gene, we developed and successfully implemented a …