Global ETD Search
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Showing 1 to 8 of 8 for “"BAX/BAK"”.
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Regulation of BAX/BAK-Dependent Cell Death Program
… apoptosis. Multidomain proapoptotic BAX/BAK promotes mitochondrial outer membrane permeabilization, whereas anti-apoptotic BCL-2/BCL-X<sub>L</sub>/MCL-1 protects mitochondrial integrity and prevents cytochrome c release. The proapoptotic activity of BAX/BAK is triggered by BH3-only …
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The Role of Bax and Bak in Necrotic Cell Death
… (ROS) stimulation. Here we determined that Bax and Bak, Bcl-2 family members that are master regulators of apoptosis, are also required for programmed necrosis induced by Calcium, ROS, and DNA alkylation. These results led us to hypothesize that Bax and Bak are required for MPTP opening. …
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Delineating the Steps of BAX Pore Activation
… proteolytic demolition of cells. Proapoptotic BAX & BAK effect the release of cytochrome c while their antiapoptotic counterparts like BCL-2, BCL-X<sub>L</sub>, & MCL-1 oppose this permeabilization. A third class of the BCL2 family, the prodeath BH3-only proteins, act as sentinels of cell …
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Vesicular stomatitis virus induced apoptosis occurs by a mechanism involving the activation of pro-apoptotic Bcl-2 proteins Bak and Bid and the inactivation of anti-apoptotic Bcl-2 proteins Bcl-XL and Mcl-1
… the two major proapoptotic multidomain proteins Bak and Bax, Bak is more important for the induction of apoptosis by rWT virus. Additionally activation of proapoptotic BH3-only protein Bid through activation of caspase-8 also plays an important role. Finally, inactivation of both antiapoptotic …
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Molecular Mechanisms of Programmed Necrotic Death Initiated by Intrinsic Death Signals
… the essential mitochondrion apoptosis effectors BAX and BAK to execute death. Yet, combined loss of Bax and Bak causes developmental and homeostatic defects in restricted tissues, indicating the existence of additional death program(s). By using Bax-/-Bak-/- double- knockout (DKO) mouse embryonic …
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Reorganization of mitochondrial architecture during apoptosis and mitophagy as investigated by correlative microscopy
… to these biological processes. During apoptosis, Bax/Bak oligomerize and accumulate in and adjacent to the outer mitochondrial membrane, resulting in outer membrane ruptures several hundred nanometers wide. Using correlative microscopy, it was found that Bax clusters accumulated next to outer …
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Studies on the Mechanisms of Malignant Transformation in Neurofibromatosis Type 1
… 따라서, apoptosis 조절에 관련하는 단백질들의 발현량을 확인한 결과, p53, Bax, Bak의 경우 발현양이 비슷하였으나, anti-apoptotic protein인 Bcl-2는 정상표현형세포에서 악성으로 갈수록 발현양이 감소되어있었고, Bcl-xL의 경우 Bcl-2와는 반대로 악성종양세포에서 발현양이 크게 증가되어있었다. Anti-apoptotic protein인 Bcl-xL은 Ras signal pathway의 최하위에 존재하는 단백질중의 하나로써 STAT3에 의해 발현되고, 세포변형의 1차적 반응이자 즉각적 …
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Doxorubicin combined with phytochemicals as pro-apoptotic agents and protein kinase inhibitors for the treatment of acute myeloid leukaemia
… were conducted. Expression of various proteins (Bax, Bak, Bcl-2, caspase 3, 8 and 9, p53, p21, p16, cdc25s and FLT3) were determined using Western blot technique, and ELISA to confirm FLT3-ITD phosphorylation. Statistical analysis including ANOVA, Student T-test were chosen for comparing the …