Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"BARD1"”.
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The role of the BARD1 BRCT domains in the DNA damage response
… is almost always found in the nucleus bound to BARD1. BARD1 retains BRCA1 in the nucleus and enhances the E3 ubiquitin ligase function of BRCA1. The importance of BRCA1 in the repair of DNA DSBs has been extensively researched, however the role of BARD1 in repair remains unknown.<br/> Similar to …
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Derivation and Comparison of Androgenic and Gynogenic Monoploid Potato Families
… crossed to two selections of S. phureja (PP5 and BARD1-3). A total of 185 fruit was obtained from PP5 and 398 from BARD1-3, resulting from 85% and 65% fruit set, respectively. Seed lacking the dominant embryo spot marker carried by IVP101 were selected and germinated in vitro. From 29,300 PP5 x …
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Effects of BRCA1-Mediated Ubiquitination of HuR on RNA Metabolism in Breast Cancer
… cellular processes. BRCA1, together with BARD1 (BRCA1 Associated RING Domain 1) also functions as an E3 ubiquitin (Ub) ligase. BRCA1 mutation in the RING domain, which is responsible for E3 ligase activity, is associated with increased risk of developing breast cancer. Despite extensive …
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Two Redundant Ubiquitin-dependent Pathways of BRCA1 Localization to DNA Damage Sites
… domain. BRCA1 RING mutations that do not impact BARD1 interaction, such as the E2-binding deficient I26A mutation, renders BRCA1 unable to accumulate at DNA damage sites in the absence of RAP80. Cells that combine BRCA1 I26A and mutations that disable the RAP80-BRCA1 interaction are …
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Analysis of The RING Domain And BRCT Repeats of BRCA1
… enhanced when it forms a heterodimer with Bard1. This region is of particular interest because it displays the only known enzymatic activity of BRCA1. The BRCT repeats have phosphopeptide binding activity, which is necessary for BRCA1's interaction with DNA repair proteins BACH1, ABRAXAS, …
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Γενετική ανάλυση στον κληρονομικό καρκίνο του μαστού
… PALB2, BRIP1, TP53, PTEN, STK11, CDH1, ATM, BARD1, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, PMS1, PMS2, RAD50, RAD51C) με την χρήση τεχνολογίας αλληλούχισης επόμενης γενεάς. Για το σκοπό αυτό αναλύθηκαν 42 ασθενείς με σοβαρό ιστορικό καρκίνο μαστού ή/και ωοθηκών, οι οποίες είχαν βρεθεί αρνητικές …
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A Structural Approach to Unveil the Role of BRCA1 in the Context of Transcription
… 3D reconstruction, atomic models of the BRCA1-BARD1 heterodimer and the RNAP II core in regions of major unoccupied density. Other areas of minor missing density were overlaid with a short strand of DNA and ubiquitin moieties, which proved agreement with Co-IPs. Next we sought to compare the …
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Rare Genetic Variants and Cancer Susceptibility
… variants and some rare missense variants in ATM, BARD1, BRCA1, BRCA2, CHEK2, RAD51C, RAD51D, PALB2 and TP53. However, these variants together explain less than half the familial relative risk of breast cancer. Similarly for other cancers, GWAS have identified many susceptibility loci and rare …
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Genetic Testing Uptake and Yield in Patients with Male Breast Cancer
… cancer risk genes (HBCRG): <em>ATM</em>, <em>BARD1</em>, <em>BRCA1</em>, <em>BRCA2</em>, <em>CDH1</em>, <em>CHEK2</em>, <em>NF1</em>, <em>PALB2</em>, <em>PTEN</em>, <em>RAD51C</em>, <em>RAD51D</em>, <em>STK11</em>, and <em>TP53</em>, and compare genetic testing uptake and yield of gPV in the …
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Integrated data analytics of germline mutation classes in human cancers. An integrated bioinformatics analysis to investigate associations between germline mutation classes and human cancers.
… From the PIPM, it was evident that BRCA1, MSH6, BARD1, TP53, MSH2 and CHEK2 proteins best connected Breast, Ovarian, Prostate and Bowel primary cancers, and so the latter could represent ¿driver proteins¿ for these cancers. In summary, this project has approached the analysis of gene involvement …
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Integrated data analytics of germline mutation classes in human cancers. An integrated bioinformatics analysis to investigate associations between germline mutation classes and human cancers.
… From the PIPM, it was evident that BRCA1, MSH6, BARD1, TP53, MSH2 and CHEK2 proteins best connected Breast, Ovarian, Prostate and Bowel primary cancers, and so the latter could represent ¿driver proteins¿ for these cancers. In summary, this project has approached the analysis of gene involvement …