Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"BAFF"”.
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Enhancement of the An1 Population by BAFF: Potential Role in Autoimmune Disease
The cytokine BAFF is a TNF family member found to be essential for the homeostasis of B cells. Numerous studies have shown BAFF to be involved in the pathogenesis of autoimmune diseases, including Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis. In an effort to understand the role of …
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Charakterisierung des Zytokins BAFF als wichtiger Regulator der B-Zellfunktion beim Haushuhn
… activating factor belonging to the TNF family” (BAFF) in a chicken EST-database. The cDNAs encoded for the complete open reading frame of chicken BAFF (chBAFF) including a transmembrane domain and a potential furine cleavage side. ChBAFF shows an uncommon high amino-acid sequence identity with …
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B Lymphocyte Development in Galt
… a B7-CD28 independent, CD40-CD40L, CR2-CR2L, and BAFF-BAFF-R dependent manner. Using several cross-reactive antibodies, I identified subpopulations of transitional (T1 and T2) B cells in the peripheral tissues of both young and adult rabbits. Unlike in other species, T1 B cells in rabbit were …
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Modulation of Obesity and its Sequelae by Microbiome/Immune System Interactions
… in thermogenic tissues. These findings led us to BAFF, a “B-cell” cytokine that is predominately derived from non-hematopoietic sources during homeostasis. RP105-/- mice exhibit augmented BAFF expression. Such BAFF overexpression was also found to be associated with protection from obesity in …
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Molekulare und funktionelle Analyse von Lymphocyten aus Patienten mit primären Immundefizienzerkrankungen
… Monaten erstmalig genetische Defekte (ICOS, BAFF-R, TACI) entdeckt, die das Antiköpermangelsyndrom verursachen. CVID umfasst insofern eine heterogene Gruppe von Immundefekten. <br>Im Rahmen dieser Arbeit konnte die gestörte Expression des BAFF-Rezeptors, sowie Defekte im Reaktionsprozess des …
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B Cell Signaling and Bioinformatics: Revealing Components of the MHC Class II Antigen Processing and Presentation Pathway
… Alliance for Cellular Signaling (AfCS): 1) the BAFF/CD40L project, which evaluates the effects of BAFF and CD40L on primary mouse B cells in long-term cultures, and 2) the B cell single ligand screen project, which evaluates the effects of 32 single ligands on primary mouse B cells in short-term …
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Insights into the Iimmune Mechanisms Leading to Lupus-like Autoimmunity in New Zealand Black Mice
… cells (pDC), and elevated gene expression of baff were maintained in CD40L-deficient NZB mice, despite the lack of IgG immune complexes. Chapter 3 utilizes bicongenic mice carrying both NZB chromosomes 1 and 13 to investigate the genetic complexity in disease pathogenesis. In addition to …
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Immunological, vascular and metabolic actions of androgens
… regulation of splenic stroma and the cytokine BAFF, 2) protect against atherosclerosis in a T cell-dependent manner and that thymic epithelial cells is a likely AR target for atheroprotection, 3) increase angiotensin II-induced aortic neutrophil infiltration and abdominal aortic aneurysms by …
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Characterization of human IgA-inducing protein
… nodes. DC-produced survival factors such as BAFF and APRIL have been shown to be essential for B cell maturation, but have also been implicated in class-switch recombination and B cell lymphoma survival. Recently added to this list of DC-derived factors effecting B cells is IgA-inducing …
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Plasmablasten mit einem mukosalen Phänotyp als Biomarker für die Granulomatose mit Polyangiitis?
… konnten signifikant erhöhte Serumspiegel von BAFF und erstmals auch APRIL nachgewiesen werden. Bei den Plasmazellen war der Anteil IgA+ Zellen signifikant gesteigert. Die Expression mukosaler Marker wie CCR10 und α4β7-Integrin war tendenziell erhöht, jedoch ohne eindeutige Signifikanz. …
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Cellular requirements for antibody production in a novel LPS-enhanced model of autoimmune myasthenia gravis
… sera levels of the Bcell survival factor, BAFF. Our results indicate that LPS abrogated B cell differentiation\r\nto antibody secreting cells in the LPS-EAMG model. Furthermore, CD8-/- mice were\r\nalso susceptible to the development of LPS-EAMG, but were resistant to the development of …
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Sex steroid hormones - roles in adaptive immunity and vascular pathology
… and inhibition of B cell activating factor (BAFF) production. Moreover, testosterone exerts atheroprotection through AR-dependent as well as AR-independent pathways. The AR also mediates protection from neointimal hyperplasia as a response to vascular injury, possibly through regulation of …
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Monogenetic Immune Dysregulation Syndromes and their Effect on the Plasma Cell Compartment
… subset of patients had increased serum levels of BAFF. Both cytokines are involved in B cell maturation. II. As a model for the possible action of Abatacept, 8 treated patients with arthritis (RA) were studied. Abatacept is a biological agent, stabilising CTLA-4 signalling, used for many years to …
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The Use of Surface Cytokines as Biomarkers in B Cell Mediated Autoimmune Diseases
… RA and SLE patients. As discussed above, APRIL, BAFF and TSLP have been implicated in the pathogenesis of RA and SLE. Current therapeutics used to treat RA and SLE provide sub-optimal response in a third of patients treated. Therefore, identifying subsets of patients based on their surface and …
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Molecular, functional and developmental analysis of B cells at discrete stages of development
… of the cell surface receptors CD23, CD44, IgD, BAFF-R and of the pro-survival protein Bcl-2 compared to the CD21lo subset. Consistent with these findings, CD21hi transitional B cells exhibited greater in vitro survival and proliferation than CD21lo transitional B cells. Based on the level of …
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Lymphocyte subset variability between human lymphoid tissues
… phenotype including differences in CCR7 and BAFF-R expression. IgM-only B cells also included two populations with different phenotype and tissue-specific abundances. Single-cell RNA sequencing was used to further investigate the differentiation, functional, and dissemination differences of …
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Identifizierung, Charakterisierung und funktionelle Analyse der Bindungspartner von APRIL und TACI auf Monozyten und Dendritischen Zellen
… (engl.: a proliferation inducing ligand) und BAFF (engl.:B cell activating factor of the tumor necrosis factor (TNF) family) sind zwei eng verwandte Liganden innerhalb der TNF-Familie. Beide Liganden teilen sich zwei Rezeptoren, TACI (engl.: transmembrane activator and CAML interactor) und …
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Understanding T cells in type 1 diabetes: a role for c-Maf and characterization of intracellular signaling following engagement of transgenic Ly49A.
… expression of the downstream targets Bcl-xl and Baff were unaffected. Together these data suggest that engagement of Ly49A selectively inhibits signals downstream of the TCR but spares those unique to CD28. These results suggest that when considering its use as an immunotherapy, the potency of …
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B cell therapy in ANCA-associated vasculitis
… to evaluate the early pharmacodynamic effects of BAFF antagonism with belimumab on B cells and B cell subsets in patients with active AAV. A combination of flow cytometry and scRNA-seq was used with the primary aim of understanding the mechanisms driving the early rise in circulating B cell …
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