Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"BACH2"”.
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BACH2 orchestrates thymic T cell differentiation and functional programming
… understood. The transcriptional repressor BACH2 has been widely studied in lymphocyte lineage cells, but its role in thymic T cell development has been overlooked. This thesis presents the first in-depth characterisation of BACH2 within T cell development. Expression of BACH2 is induced …
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Mechanisms of CD4+ Regulatory T Cell Heterogeneity in Health and Disease
… to be understood. The transcription factor BACH2 is critical for early Treg cell lineage specification, however, its function following Treg lineage-commitment is unresolved. The studies detailed herein demonstrate that Bach2 is highly expressed during Treg cell development in the thymus. …
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Enhancing T cell immunotherapy through dosing of memory transcription factors
… that depend on the memory transcription factor BACH2. These cells maintain stem-like potential while giving rise to short-lived effector cells. Here, I show that quantitative control of BACH2 dosage governs the physiological continuum of stem and effector CD8+ T cell states, a principle that can …
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The transcriptional programme of natural killer (NK) cell functional maturation and maintenance
… elucidated. The transcriptional repressor BACH2 plays a critical role within the adaptive immune system but its function within innate lymphocytes has been unclear. The studies presented here show that BACH2 acts as an intrinsic negative regulator of NK cell maturation and function. BACH2 …
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Control of chromatin accessibility during CD4+ T cell development and activation
… of the two signals at many regulated loci. BACH2 is a transcriptional repressor whose expression is predominantly restricted to lymphocytes. Whether the suppression role of BACH2 is mainly through steric competition with the AP-1 family or involves other mechanisms is currently unclear. To …
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Screening for genes involved in CD8⁺ T cell cytotoxicity and characterisation of a super-killer
… Arpc1b, involved in actin filament branching; Bach2, a transcriptional regulator; Lrrc8d, a component of the volume-regulated anion channel and Oaf, an orphan gene. Bach2 deficient murine CTL exhibited a marked increase in lytic capacity and was chosen for further investigation. Bach2 codes for …
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The Genetics of Anti-Neutrophil Cytoplasmic Antibody Associated Vasculitis (AAV)
… EBF3-MGMT, IGHV1-69), two with MPO-AAV (BACH2, ANKRD11-SPG7) and two shared by both (CTLA-4 and DGUOK-TET3). Further analyses based on common variants suggested that a substantial component of the genetic architecture was shared between PR3-AAV and MPO-AAV, similar to that observed …
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Metabolic Disorders Rewire Systemic and Tumor Immunity to Shape Anti-Tumor Responses in Cancer Patients
… producing an ISR-uncoupled state that sustains BACH2/BTLA-mediated differentiation restraint in B cells. This two-checkpoint model explains how MASH-associated metabolic stress first blocks germinal center B cell progression into plasma cells, then drives apoptosis of mature plasma cells whose …
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Studying the B and plasma cell responses to the immune checkpoint blockade treatment of cancer
… germinal centre B cells displayed elevated Bach2 and Il21r expression, suggesting they may hold a competitive advantage within a germinal centre reaction. Interestingly, cells from ICB-treated mice appeared to preferentially display the CD52-low germinal centre phenotype compared to cells …
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Genomics of sickle cell disease and fetal hemoglobin in African populations
… as well as to identify new loci including BACH2 involving a meta-analysis of African Americans and Tanzanians, SLC28A3, TICRR, and PIEZO2 in Nigerians, and FRMPD4 in Tanzanians. While BCL11A and HBS1L-MYB have been replicated in Cameroonian SCD patients through candidate genotyping studies, …