Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"BACE-1"”.
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Zwei neuartige Aspartylproteasen BACE-1 und BACE-2
… Hauptanteil der b-Sekretase Aktivität ist auf BACE-1, eine neuartige membrangebundene Typ I Aspartylprotease, zurückzuführen. Um gezielt spezifische und wirksame Inhibitoren entwickeln zu können, ist es notwendig, die Eigenschaften und katalytischen Spezifitäten der Protease genauer zu …
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Amyloid precursor protein subtypes and secretases implicated in Alzheimer's disease.
… APP[695]; ADAM 9, 10 and 17 as alpha-secretases; BACE 1 as beta-secretase and PS1 as gamma-secretase.The APP[695] isoform was found to have the highest levels in the frontal and temporal regions. However, the APP[751] isoform was found to be at the highest level, with very low levels of APP[695] …
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The role of mTOR signaling in Alzheimer s disease
… of tau and the beta-site APP cleaving enzyme 1 (BACE-1), a key enzyme in the generation of amyloid-â. Given the overwhelming evidence showing that reducing mTOR signaling increases lifespan and health span, the data presented here have profound clinical implications for aging and AD and provide …
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Synthesis and evaluation of novel multi-target compounds for the treatment of Alzheimer's disease.
… tau in vitro, as well as strong inhibition of BACE-1 and moderate inhibition of MAO-B. In cell-based models, the compounds reduced oxidative stress and lipid peroxidation and could act as anti-apoptotic and anti-inflammatory agents. The novel compounds could reduce the activity of …
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Reconstituting APP and BACE in proteoliposomes to characterize lipid requirements for β-secretase activity
… ("secretases"). The beta-secretase, BACE, cleaves APP in the first step of processing leading to the formation of the neurotoxic Abeta. BACE competes for APP with alpha-secretase, which cleaves APP within its Abeta sequence, thus precluding Abeta formation. It is thus important to …
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Pathomechanismen der sporadischen Einschlusskörperchenmyositis
… eine zytokinbedingte Hochregulation von BACE1 in vitro belegt werden. Durch siRNA-vermittelten knock down ließ sich die Akkumulation von β-Amyloid im entzündlichen Milieu verhindern. Hierdurch kam es zu einem deutlichen Rückgang von sIBM-relevanten Entzündungs- und Degenerationsmarkern …