Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"BACE"”.
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Zwei neuartige Aspartylproteasen BACE-1 und BACE-2
… Hauptanteil der b-Sekretase Aktivität ist auf BACE-1, eine neuartige membrangebundene Typ I Aspartylprotease, zurückzuführen. Um gezielt spezifische und wirksame Inhibitoren entwickeln zu können, ist es notwendig, die Eigenschaften und katalytischen Spezifitäten der Protease genauer zu …
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Reconstituting APP and BACE in proteoliposomes to characterize lipid requirements for β-secretase activity
… ("secretases"). The beta-secretase, BACE, cleaves APP in the first step of processing leading to the formation of the neurotoxic Abeta. BACE competes for APP with alpha-secretase, which cleaves APP within its Abeta sequence, thus precluding Abeta formation. It is thus important to …
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Polymer Supported Lipid Bilayer Membranes for the Integration of Transmembrane Proteins
… beta amyloid precursor protein cleaving enzyme (BACE). Integrated BACE was observed to be mobile on all polymer cushions. On the contrary, no lateral mobility of BACE was found in solid sLBM. Furthermore, the activity of integrated BACE was analysed by the cleavage of an amyloid precursor protein …
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Treatment coverage, barriers to care and factors associated with help-seeking behaviour of adults with depression and alcohol use disorder in Chitwan district, Nepal
… tool, the Barriers to Care Evaluation Scale (BACE). Results: Overall, 11.7% (n=13) people with depression in the follow-up survey reported that they had received mental health treatment from any provider in the 12 months preceding the survey; this proportion was not significantly different …
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Why now : a quantitative analysis of barriers influencing a delay in treatment-seeking behavior for adults with obsessive-compulsive disorder.
… the Barriers to Access to Care Evaluation scale (BACE; Clement et al., 2012). A total of 104 adults with a self-reported OCD diagnosis completed an anonymous online survey. Mood’s Median results showed no statistically significant difference in BACE v3 scores between those who sought treatment …
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Amyloid precursor protein subtypes and secretases implicated in Alzheimer's disease.
… APP[695]; ADAM 9, 10 and 17 as alpha-secretases; BACE 1 as beta-secretase and PS1 as gamma-secretase.The APP[695] isoform was found to have the highest levels in the frontal and temporal regions. However, the APP[751] isoform was found to be at the highest level, with very low levels of APP[695] …
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An Examination of Racial and Ethnic Differences in Internalized Mental Health Stigma and Perceived Mental Health Barriers Due to Stigma Among Women Veterans
… to Care Evaluation Treatment Stigma Subscale [BACE-TSS]). A multivariate analysis of covariance was conducted to examine if there were groups differences based on race/ethnicity in internalized mental health stigma and barriers to access to care due to mental health stigma while covarying for …
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Black Women, Black Pride, and Mental Health: How Does the Power of an African American Woman’s Cultural Pride Influence her Perceived Barriers to Mental Health Care?
… the Barriers to Access to Care Evaluation (BACE-3), which assesses a wide range of perceived barriers to mental health services, and an adapted version of the Racial Identity Scale (RIS) from Ford (1995), which was used to measure levels of cultural pride. Stepwise analyses examined the …
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The Challenges Facing Academic Staff In Higher Learning Institutions: A Case Study Of Lipinyapinya Institute Of Education In Tanzania
… and Bachelor of Adult and continuing Education (BACE) students were obtained through random sampling technique. Data was collected through qualitative and quantitative research approaches. The data collection techniques used in the study included interviews, questionnaires, observation and …
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THE CHALLENGES FACING ACADEMIC STAFF IN HIGHER LEARNING INSTITUTIONS: A CASE STUDY OF LIPINYAPINYA INSTITUTE OF EDUCATION IN TANZANIA
… and Bachelor of Adult and continuing Education (BACE) students were obtained through random sampling technique. Data was collected through qualitative and quantitative research approaches. The data collection techniques used in the study included interviews, questionnaires, observation and …
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The role of mTOR signaling in Alzheimer s disease
… of tau and the beta-site APP cleaving enzyme 1 (BACE-1), a key enzyme in the generation of amyloid-â. Given the overwhelming evidence showing that reducing mTOR signaling increases lifespan and health span, the data presented here have profound clinical implications for aging and AD and provide …
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CHRONIC STRESS REVEALS COGNITIVE IMPAIRMENT IN A SUBTHRESHOLD AMYLOID-BETA MODEL OF ALZHEIMER’S DISEASE
… CREB and BDNF and increased basal levels of BACE. Furthermore, multiple high frequency stimulation failed to increase levels of p-CREB and BDNF during the late-phase of long-term potentiation. However, paired pulse stimulation produced a decrease in levels of BDNF during long-term depression …
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Synthesis and evaluation of novel multi-target compounds for the treatment of Alzheimer's disease.
… tau in vitro, as well as strong inhibition of BACE-1 and moderate inhibition of MAO-B. In cell-based models, the compounds reduced oxidative stress and lipid peroxidation and could act as anti-apoptotic and anti-inflammatory agents. The novel compounds could reduce the activity of …
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A receiver-compatible noise reduction system
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1990.
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Molekulare und funktionelle Analyse der Drosophila-Mutante löchrig
… loe-Mutation die b-Sekretase aus Vertebraten (BACE) und eine bisher noch nicht beschriebene endogene Sekretase aus Drosophila negativ beeiflusst werden. Ein AMPK-Komplex mit LOE I als g-Untereinheit scheint über den Cholesterinester-Spiegel die Aktivität einer speziellen Untergruppe der …
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Identification of the cellular mechanisms undelying the contribution of stress and glucocorticoids to Alzheimer's disease pathology
… the expression of APP-cleaving enzymes (BACE and nicastrin), giving rise to the APP C-terminal fragment 99 (C99) which, after further processing, yields amyloid beta (A). While A is the APP product to which AD pathology is usually ascribed, C99 also has deleterious effects on neuronal …
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Correlation between dynamic parameters and device performance of organic solar cells
… new technique {Bias Assisted Charge Extraction} (BACE) was developed. Here, the charge carriers photogenerated under steady state illumination are extracted by applying a high reverse bias. The accelerated extraction compared to conventional charge extraction minimizes losses through non-geminate …
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The Processing of Amyloid Precursor Protein in the Central Nervous System of Humans and Rhesus Macaques
… intervention of the β-secretase pathway by a BACE1 inhibitor would affect the α-secretase pathway. Soluble APPβ, sAPPα and Aβ were isolated from rhesus macaque CSF by serial immunoprecipitation. Monkeys were undergoing stable isotope labeling kinetics studies. Isolated APP metabolites …
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Pathomechanismen der sporadischen Einschlusskörperchenmyositis
… eine zytokinbedingte Hochregulation von BACE1 in vitro belegt werden. Durch siRNA-vermittelten knock down ließ sich die Akkumulation von β-Amyloid im entzündlichen Milieu verhindern. Hierdurch kam es zu einem deutlichen Rückgang von sIBM-relevanten Entzündungs- und Degenerationsmarkern …