Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"BAC transgenesis"”.
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Molecular and Functional Characterization of Pyramidal Cell Types in the Frontal Cortex of Mouse Brain
… functionally coherent cell populations. Using BAC modification strategy, we targeted distinct cell types in the neocortex for expressing effector molecules such as EGFPtagged ribosomal protein L10 and Cre recombinase. We generated bacTRAP transgenic mice for six pyramidal cell types in the …
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Mechanisms and functional significance of nuclear compartmentalization
… In Chapter 2, we used autonomous targeting of BAC transgenes to reveal cis requirements for peripheral targeting. Three peripheral targeting regions (PTRs), including the 6 kb PTR1, target the ~100 kb beta-globin gene cluster and LCR region to the nuclear periphery and confer increased H3K9me3 …