Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"B7-H4"”.
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Role of Il-17/Il-17Ra Signaling In The Pancreatic Tumor Microenvironment
… the epithelial global analysis, regulation of B7-H4 emerged as one of the main immune-related pathways driven by IL17A. B7-H4 is a negative regulator of T cells through Eomes activation. To further investigate the significance of B7-H4 during tumorigenesis, we generated transgenic mice lacking …
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Differential progression of pancreatic premalignancy in geographically distant murine transgenic cohorts uncovers key role of microbial metabolites
… of premalignant lesions. We identified that B7-H4, a known inhibitor of T cell activation was highly upregulated via IL-17 during the early stages of tumorigenesis. In addition to increased expression of B7-H4, we identified increased levels of T cell exhaustion marker, Eomes. Histological …
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Immune checkpoints in oral carcinogenesis
… in OSCC. Seven of them (ALHD1, FKBP51, PD-L1, B7-H3, B7-H4, B7-H6, and IDO1) had been reported as adverse prognostic factors and five (CTLA-4, PD-1, PD-L2, TLT-2 and VISTA) did not have prognostic value. Only two molecules, PD-L1 and B7-H3, had sufficient data for conducting a meta-analysis. …