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Showing 1 to 2 of 2 for “"B4GALT6"”.
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IS B4GALT5 DEFICIENCY A NEW CONGENITAL DISORDER OF GLYCOSYLATION?
… two similar galactosyltransferases, B4GALT5 and B4GALT6, are both responsible for the synthesis of lactosylceramide (LacCer), the precursor of many GSLs. B4GALT5 appeared more relevant, but B4GALT6 was still able to rescue B4GALT5 KO in mice. Genome analysis of a patient revealed a compound …
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DISEASE-MODIFYING APPROACHES TO MULTIPLE SCLEROSIS: DESIGN AND SYNTHESIS OF NOVEL POTENTIAL THERAPEUTIC AGENTS
… of MS. LacCer is synthetized by the enzyme B4GALT6, which is mostly expressed by reactive astrocytes. The blockage of B4GALT6 caused a halt to the progression of the disease in MS models, and this effect was reverted by an external administration of LacCer. However, currently only one …