Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"B2M"”.
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Expression und immunmodulatorische Funktion von HLA-G und seinen verkürzten Isoformen in Tumorzellinien
… könnte auf einer gestörten Assoziation mit b2m oder Bestandteilen der MHC-Klasse-I-Prozessierungsmaschinerie beruhen. Kopräzipitationsexperimente ergaben, daß nur die HLA-G1-schwere Kette mit b2m und TAP assoziiert ist. HLA-G2 ließ sich zwar mit TAP, jedoch nicht mit b2m kopräzipitieren und …
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Towards Mammalian Retinal Regeneration: Cell Signaling in Re-Differentiating Mouse Müller Glia and Transcriptional Regulation of the Axonal Guidance Receptor EPHA5
… commonly used reference gene, β-2 microglobulin (B2m), which has been implicated in retinogeniculate synaptic remodeling. Thus POU4F2 may repress B2m expression, but does not regulate EphA5, EphA6, or Klf16 expression. In conclusion, in vitro differentiation of ImM10 Müller glia results in …
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The Characterization of Hemodialysis Membranes in Miniaturized Dialyzers
… coefficient, clearance of Beta-2 Microglobulin (B2M), and SC of B2M.These outcomes suggest that the miniaturized dialyzers can effectively differentiate performance characteristics representing hemodialysis membrane and fiber design. This indicates that the miniaturized dialyzers are an …
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Loss of Ptdss1 in tumor cells improves anti-PD-1 therapy
… expression of IFNγ-regulated genes, including B2m, Cxcl9, Cxcl10, and Stat1. Loss of PTDSS1 in tumor cells also led to increased expression of MHC-I, which was associated with increased expression of cytolytic function related genes in CD8<sup>+</sup> T cells and increased frequency of an …
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Proceso apoptótico y respuesta simpática en tejido cardiaco durante la muerte encefálica
… de genes (GADPH, PPIA, ACTB, YWHAZ, ARN 18S, B2M, UBC, TBP, RPLP y HPRT) para ser usados como genes de referencia para la normalización de datos obtenidos en estudios de expresión génica en tejido humano procedente de donantes en muerte encefálica. Los principales resultados obtenidos fueron: …
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Evaluation of Endothelial Cell Responses to Elevated Glucose
… Next, activity of potential reference genes B2M, HPRT1, and ACTB was assessed. All genes were found to exceed acceptable variability, so the E-ΔC T method of data analysis was selected. Next, cellular responses to high glucose treatment at 10.5 mM glucose and 25.5 mM glucose for 7 and 14 days …
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An evaluation of genetic markers for forensic identification of human body fluids
… genes (UCE, TEF, GAPDH, 18S rRNA, ACTB, B2M, B-Actin, OAZ1, RPS 29 and S15) were studied to establish an appropriate reference gene in body fluid identification. These are constitutive genes used for normalisation of gene expression data and control of variations in experiments. qRT-PCR …
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Integrative genomic approaches to dissecting host-tumor and host-pathogen immune processes
… activity, including beta-2- microglobulin (B2M), HLA-A, -B and -C and Caspase 8 (CASP8), highlighting loss of antigen presentation and blockade of extrinsic apoptosis as key strategies of resistance to cytolytic activity. Genetic amplifications were also associated with high cytolytic …
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Investigating biomarkers in clinical samples that are predictive of response in multiple myeloma
… Amyloid A protein (SAA), Beta-2-microglobulin (B2M), had higher abundance level with fold changes of 1.31 (p=0.00044), 1.32 (p=0.0077), 1.48 (p= 0.0000022), 3.01 (p=0.006) and 1.96 (p=0.0015) fold increase in non-responders compared to responders, respectively. In contrast Haptoglobin (Hp) had a …
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Proteomic approaches for the identification of biomarkers of beef tenderness from Longissimus thoracis muscles and plasma of young Limousin-sired bulls
… and transport pathways. More specifically, B2M, AHSG, APOA4 and HP-20 (plasma), PFKM, MYH2, PTER, GSTM1 and MYPN (muscle) were good predictors of tenderness, juiciness and chewiness. Five explanatory models were built to explain various beef quality traits, specifically, MYOZ3, BIN1 and OGN …
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The immunogenicity of embryonic stem cell-derived midbrain dopaminergic progenitors and its implications as a therapy to treat patients with Parkinson’s Disease
… ability and immunogenicity in vitro. B2M protein, that stabilizes the MHC class I complex, was knocked out using CRISPR-Cas9. These KO cell lines differentiated to authentic DA progenitors and neurons, and their expression of other immune molecules remained the same as their wild-type …
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Genetic factors associated with neuropathic pain
… reported variant in the iron metabolism gene, B2M, was replicated in study-II. Finally, of all 56 prior SNPs, six SNPs near GCH1, CDH18, IL13 and IL10 were significantly associated with diabetic NP.<br/><br/><b>Conclusions</b>: The studies presented in this thesis using two NP phenotyping …
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Identification of rat NKT cells and molecular analysis of their surface receptor mediated activation
… Maus und humane NKT Zellen erkennen durch CD1d-b2m Komplexe präsentiertes a-GalCer und reagieren mit Aktivierung, Proliferation und Cytokinproduktion. Um die Fähigkeit von Maus und Ratten-CD1d a-GalCer zu präsentieren, zu testen, wurde das CD1d Molekül der Ratte kloniert. Sequenzanlyse und …