Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"B230 - Pharmacy"”.
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Screening the effects of indoles on the proliferation of yeast via changes in lipid carbon flux
Indoles are privileged structures that provide a platform to develop new drugs for the treatment of complex human diseases such as cancer, metabolic syndromes, cardiovascular diseases and neurodegenerative diseases. Many substituted indoles (i.e. 2-aryl indoles) exhibit anti-proliferative effects …
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Characterisation of cytokine secretion in malignant gliomas
Cytokines are proteins produced by cells of the immune system. The working hypothesis of the thesis is to show that the lymphocytes and glial cells in Glioblastoma Multiformae patients have an altered pattern of secretion of cytokines compared with low-grade and non-cancerous patients. Lymphocyte …
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Investigating the regulation of tumour associated lipogenesis using the model organism, Saccharomyces cerevisiae
The highly conserved mitogen activated protein kinase (MAPK) high-osmolarity glycerol (HOG) pathway plays a vital role in the ability of Saccharomyces cerevisiae cells to respond to stress conditions, primarily hyperosmotic stress. In addition, there is also evidence that the HOG pathway is …
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Resveratrol Nanostructured Lipid Carrier for targeted delivery to breast cancer
Background: Breast cancer remains a prominent cause of mortality and morbidity in the female population. Despite advances in terms of novel compounds, exhibiting chemotherapeutic activity successful delivery remains challenging. Particulate-based system such as Nanostructured Lipid Carriers (NLCs) …
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The effect of specific phospholipids that may have a possible role in propagating or inhibiting glioma
Cancer is one of the major causes of death in spite of a substantial increase in understanding of the molecular mechanism behind its occurrence. Glioma is the type of brain cancer which arises in the glial cells of the brain. Glioma is categorized into three areas namely: astrocytoma, …
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Identification of polyphenoilc compounds within fruit extracts and their role in the treatment of glioma
Glioblastoma multiforme (GBM) is the most common and malignant primary brain tumour in adults. Despite current treatment options, including surgery followed by radiation and chemotherapy with temozolomide (TMZ) and cisplatin, the median survival rate remains below 16 months. Epidemiological studies …
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The role of protein phosphorylation in the switching between modes of synaptic vesicle release
Among secretory systems, the nerve terminal is unique in its capability for sustained release of vesicular contents in response to high rate stimulation and attention was focused on the presynaptic nerve terminal - by employing synaptosomes - for understanding the mechanisms occurring in synaptic …
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Involvement of CD133+ stem cells in the chemoresistance of glioma
Despite aggressive treatment strategies, malignant gliomas frequently recur and the median survival remains approximately one year for these patients. Within a heterogeneous brain tumour mass, there is a subpopulation of cancer stem cells that possess the capacity for selfrenewal, infinite …
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An investigation involving a comparison between the hydrolytic degradation of lovastatin and simvastatin using HPLC
Lovastatin (LV) and Simvastatin (SV) are known by their common general name of Statins. They are hypolipedemic drugs used for the treatment of hypercholesterolemia. Both statins are administrated as prodrugs that require metabolic activation to form the active acid forms, namely lovastatin hydroxy …
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Cytokine secretion in glioblastoma patients
Gliomas are the most common primary tumours of the central nervous system with a lethality rate approaching 80% in the first year of glioblastoma diagnosis. Their highly invasive nature renders local therapies such as surgery and radiation ineffective; whereas novel approaches such as immunotherapy …
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Proliposome and Prosurfactosome Formulations for Pulmonary Drug Delivery
This study aims to compare the efficiency of conventional liposomes and surfactant-enriched vesicles (surfactosomes) using the hydrophilic drug salbutamol sulphate (SBS) and the hydrophobic drug beclometasone dipropionate (BDP) for pulmonary delivery via nebulisation. Initially liposomes and …
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Professional engagement of locum community pharmacists
… a significant proportion of the community pharmacy workforce in the UK, and have been identified as isolated practitioners who work outside existing quality assurance processes. This study examines professional engagement of locums in terms of their networking with pharmacist colleagues and …
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Design of a Validated Stability Indicating HPLC Method for the analysis of Patrin-2 (Lomeguatrib).
Lomeguatrib or Patrin-2 has been formulated to work in combination with Temozolomide. It does so by blocking the action of ATase (MGMT), which repairs specific kinds of DNA damage and is particularly responsible for resistance to anti-cancer treatments. Patrin-2 acts as a pseudosubstrate …
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Determining the in vitro anti-cancer effects of various novel indoles and an anti-microbial peptide towards a potential treatment of glioma.
Substituted indoles (2-arylindoles) and related structures are known to exhibit potent anti-cancer activity against human breast cancer cell lines, and a range of other therapeutic targets. This activity, and other factors such as their biological activity, the fact that they are privileged …
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Anti-cancer effects and mechanism of actions of aspirin-like drugs in the treatment of gliomas
In the past two decades only modest advancements in glioma treatment have been made, with patient prognosis and median survival time following diagnosis only increasing from 3 to 7 months. A substantial body of clinical and preclinical evidence has suggested a role for aspirin in the treatment of …
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The role of Calcineurin in skeletal muscle differentiation
1. Strong evidence suggests that Calcineurin levels are higher in fast muscle fibers compared to slow-twitch in resting skeletal muscles. Activation of the Calcineurin in 4 skeletal muscle myocytes selectively up-regulates slowfiber- specific gene promoters through a mechanism involving the …
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Proliposome Technology for Protein Delivery
Growing attention has been given to the potential of the respiratory tract for systemic delivery of macromolecules, particularly proteins and peptides. However, limitations such as short transit time and loss of activity of some proteins and peptides in the respiratory tract need to be overcome. …
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Bioadhesive Microparticles and Liposomes of Anti-Parkinson Drugs for Nasal Delivery
The nasal route is highly promising for the delivery of drugs exerting local effects in the nose or for therapeutic molecules having systemic or CNS effect. This is attributed to the fact that the nasal epithelium is highly vascularized and permeable, which ensures rapid absorption of the drug. The …
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Nanoemulsion formulations for brain tumour therapy
Patients with malignant glioma have poor prognosis in spite of the advances in cancer therapy. Only 15% of the glioma patients survive more than five years after diagnosis. This is because the drug cannot reach the tumour site in sufficient amounts. The aim of this project is to investigate the …
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Effects of Thyroid hormone on Cardiomyocytes and on Glioma differentiation and proliferation
The action of thyroid hormone (TH) on cell growth, differentiation and survival during development may be of therapeutic relevance. The present study investigated the potential effects of long-term TH treatment on cardiomyocytes and on glioma tumour cell lines. This study employed neonatal …
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