Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"B2 receptor"”.
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Role of kinins in mediating vascular function in healthy pregnancy and pre-eclampsia
… it was hypothesised that alterations of kinin receptor-mediated responses may be involved in the pathogenesis of the condition. To investigate whether changes in kinin receptor activity are involved in the impairment of endothelium-dependent relaxation observed in pre-eclampsia, the effects of …
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The effects of bradykinin and angiotensin II on the thoracic aorta vasa sasorum microcirculation system
… of ANG II and BK, their antagonists (AT 2 receptor antagonist PD 123319, AT1 receptor antagonist EXP3174, B2 receptor antagonist HOE 140, B1 receptor antagonist (Leu9 ) Des Arg 10- KD (1 ?M), and nitric oxide synthase inhibitor L-NAME."--Résumé abrégé par UMI
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In Vitro and in Vivo Pharmacodynamic Characterization of the Novel Plasma Kallikrein Inhibitor Pf-04886847
… (BK). BK upon activation of its constitutive B2 receptors on endothelial cells leads to an increase in intracellular Ca2+ level and subsequent production of nitric oxide (NO) and prostacyclin (PGI2), ultimately leading to vasodilation, hypotension, increased vascular permeability and vascular …
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Inflammation, kinins, and kinin receptors
… via activation of the constitutively expressed B2 receptor, which desensitizes and is internalized upon ligand binding. The kininase I metabolite of BK, desArg9BK, on the other hand mediates chronic deleterious inflammatory responses by interacting with the B1 receptor. Although normally absent, …
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Investigation of different blood pressure regulating systems in kininogen-deficient BNK rats
… for most physiological effects mediated by the B2 receptor in both rat strains. We found that the deleterious effects of salt diet in BNK rats are in fact attributable to enhanced mineralocorticoid action. The renal mineralocorticoid receptor (MR) displayed an overexpression and several …
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G protein-coupled receptor regulation: The role of protein interactions and receptor trafficking
The superfamily of G protein-coupled receptors (GPCR) is the largest gene family in the human genome. GPCR-mediated signaling operates in every human cell, and about 50% of existing clinically useful drugs act through GPCR. Kinins are proinflammatory peptides that are rapidly produced …