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Showing 1 to 20 of 25 for “"B16F10"”.
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Nanosecond Pulsed Electric Fields Induce a Mitochondria-Independent Apoptosis in B16F10 Melanoma Cells <i>In Vitro</i>
… was administered to determine the effects on B16F10 melanoma cells evaluated by <em>in vitro</em> studies. Initial application of nsPEFs demonstrated apoptosis induction in an electric field- and pulse number-dependent manner measured by caspase activation that correlated with decrease in cell …
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Characterizing The Role of Uchl5 In Metastatic Melanoma
… a mouse model. Mice that were inoculated with B16F10 shUCHL5 cells and subsequently treated with an isotype control led to reduced tumor burden. However, mice that were inoculated with B16F10 shUCHL5 cells and were also treated with anti-mouse PD1 led to increased tumor burden. We find that …
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In vitro Untersuchungen zur Wirkung von Saccharidmimetika auf verschiedene Schritte der Metastasierung von malignen Melanomzellen
… haben gezeigt, daß sich die Adhäsion von B16F10-Mausmelanom-Zellen an Fibronectin in Anwesenheit von 40 mM 1,3-Bis-beta-D-galactopyranosyl-oxymethyl-5-hydroxymethyl-cyclohexan um 80 % inhibieren läßt. Die Wirksamkeit von Galactose als aktives Element bestätigten Adhäsionsversuche mit …
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Platelet surface receptors and melanoma metastasis
… gehemmt. Für die Experimente wurden B16F10 Melanomzellen und C57BL/6 Mäuse eingesetzt. Die Antikörper-Behandlung führte zu keiner Thrombozytopenie, welche die Metastasierungs-Ergebnisse hätte verfälschen können. Während die Blockade von GPVI in dem von uns verwendeten System keinen …
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Role of Properdin in Tumour Growth and Cell Recruitment
… of a syngeneic<br/>mouse melanoma cell line, B16F10. In comparison with macrophages from<br/>wildtype mice, macrophages from congenic properdin deficient mice showed<br/>skewing towards M2 profile, encompassing mRNA expression for genes involved<br/>in arginine metabolism, production of type 2 …
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Green Tea Polyphenol Epigallocatechin-3-gallate Inhibits Hepatocyte Growth Factor-Induced Tumor Cell Migration and Invasion In Vitro and In Vivo
… 이동과 MDCK2 세포들에서의 uPA 활성화를 억제하였다. 더 나아가 시험관내 실험에서 B16F10 흑색종양 세포의 이동과 침투를 감소시켰고 특히 생쥐를 이용한 생체 내 실험에서 종양 세포의 전이를 억제하였다. 따라서 앞으로 여러 가지 방법으로 HGF/Met 신호전달체계의 잘못된 조절에 의해 발생한 사람의 종양치료에 녹차 추출물인 EGCG가 새로운 치료법을 제시할 수 있을 것으로 생각된다. "
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Turning stealth liposomes into cationic liposomes for anticancer drug delivery
… liposomes show increased cytotoxicity in B16F10 (murine melanoma) and Hela cells at pH 6.0 as compared to pH 7.4. Liposome III shows the highest cell kill at pH 6.0 for both the cells. The control formulation IV showed no difference in cytotoxicity at pH 7.4 and 6.0. Uptake of convertible …
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Síntese e avaliação das atividades leishmanicida, citotóxica, fungicida e inseticida de derivados da vanilina contendo o núcleo 1,2,3- triazólico e obtenção de novos derivados 1,2,3-triazólicos do eugenol
… desses compostos contra as linhagens celulares B16F10 (melanoma metastático murino), Jurkat (leucemia linfoblástica aguda) e MDA-MB-231 (adenocarcinoma de mama). De modo geral, os resultados obtidos mostraram que os derivados triazólicos da vanilina avaliados apresentaram pouca eficácia em …
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Identification and Knockout of Immunodominant Endogenous Retroviral Antigen in Murine Tumor Models
… models commonly used for preclinical studies B16F10, MC38, 4T1, and CT26 were able to produce replication-competent eMLV able to infect other murine cells in vitro and T cells in vivo. Human tumors have not been shown to produce infectious ERV, and so we removed the infectious potential of …
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<i>In Vivo</i> Murine Melanoma Tumor Responses to Nanosecond Pulsed Electric Field Treatment
… An animal model was set up by injecting B16F10 mouse melanoma cells into SKH-1 mice. A treatment (Tx) of 100 pulses: 300 nanosecond duration; 40 kV/cm field strength; at 0.5 Hz rate were delivered to melanoma tumors in 120 mice. The nsPEF Txcaused tumor self-destruction with sharply …
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Trans-2-aminocyclohexanol as a pH-sensitive conformation switch in liposomes
… <p>Luciferase gene transfection was conducted on B16F10 cultured cells. The lipoplex comprising trans-2-aminocyclohexanollipid 1 significantly enhanced the Luciferase gene expression. The gene transfection efficiency correlated well with the pH-triggered membrane-rupture in the …
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Synthese von multivalenten Saccharidmimetika als Liganden für Zellmembran-Lectine und als Inhibitoren der Zelladhäsion und Invasion
… die Adhäsion von stark metastasierenden B16F10 Zellen. Ferner konnte die Migration der B16 Zellen durch extrazelluläre Matrix signifikant durch die synthetischen Galactoside gehemmt werden. Molecular Modeling Studien wiesen zudem strukturelle Ähnlichkeiten zwischen dem Tumorantigen Ley …
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Mouse Melanoma Model for Evaluating Anti-Cancer Effects of Nanoparticles, Composites and Conjugates
… in vitro. A dose-response model introducing B16F10 melanoma cells to mice with an intact immune system was established. Growth of tumor cells was further assessed before and after treatment, with poly I:C treatment significantly reducing tumor volume. However, poly I:C-ZnO treatment did not …
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Induction of Immunogenic Cell Death via Nanoparticle-Mediated Dual Chemotherapy and Photothermal Therapy
… cancer cells, MDA-MB-231 breast cancer cells and B16F10 melanoma cells, in vitro. Analysis of DAMP presentation after treatment demonstrated that NPs could induce ICD. Next, the potential of NP fabrication on a large scale was studied using a high throughput fiber reactor. Poly(lactic-co-glycolic …
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Synergistically active curcumin resveratrol solid lipid nanoparticles for treatment of melanoma
… has potential to stop cell migration of B16F10 melanoma cells. Both Cur-Res SLNs and solution of curcumin and resveratrol at the ratio of 3:1 demonstrated a strong synergism on the cytotoxicity of SK-MEL-28 cell line. However, one of the limitations of this study is low drug loading which …
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Εργαστηριακή μελέτη της επίδρασης της ανοσοθεραπείας στο εντερικό μικροβίωμα πειραματικού μοντέλου mus musculus με μελάνωμα
… (anti-CTLA-4/PD-1), μόνο μελάνωμα (κύτταρα B16F10), και συνδυασμός μελανώματος με ανοσοθεραπεία. Μετά από πειραματική περίοδο 15 ημερών, συλλέχθηκαν δείγματα κοπράνων και εκχυλίστηκε μικροβιακό DNA για αλληλούχιση 16S rRNA. Εφαρμόστηκαν ειδικές στατιστικές αναλύσεις όπως Kruskal-Wallis και …
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Novel non-viral delivery systems for cancer gene therapy
… in DAB-PEG-Lactoferrin: DNA ratio of 20:1 in B16F10 cells, respectively. When the formulations modified with PEG were compared with formulations without PEG in three cell lines, DAB-PEG-transferrin showed higher gene expression compared to DAB-transferrin, unlike DAB-lactoferrin, which led to …
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Functional Genomic Studies of Cancer Immune Evasion Using In Vitro and In Vivo CRISPR/Cas9 Genetic Screens
… in models of MC38 (mouse colon cancer) and B16F10 (mouse melanoma) cell isografts. Furthermore, two separate genome-wide in vivo screens have been completed in MC38 cells, which have enabled the identification of a number of candidate genes. Initial results indicated that disruption of …
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The role of tapasin and its isoforms in antigen presentation and tumor immunity
… in MHC-I-deficient tumor cell lines, B16F10 and CMT.64, which are deficient in TAP and tapasin. Virally-driven TAP1 and Tapasin expression increased MHC-I expression in the tumor cell lines, augmented tumor cell immunogenicity, and decreased tumor growth in vivo due to increased tumor …
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Identifying regulators of natural killer cell development through CRISPR screening of common lymphoid progenitors
… such as granzyme B, and mice challenged with B16F10 melanoma cells had more lung metastasis. Finally, the developmental niche of ILCs was studied using immunohistochemistry of bone cryosections, and the role of Notch signalling as a potential regulator of E2A was studied. Overall, the work …
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