Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"B16-f10"”.
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Photofrin-Mediated Electroporation-Assisted Photodynamic Therapy of MCF-7 Human Breast Cancer and B16-F10 Mouse Melanoma Cells
… Photofrin content in both MCF-7 and B16-F10 cell lines in those samples subjected to electroporation and an equal Photofrin concentration compared to the non-electroporated samples. In evaluating the cytotoxicity of photodynamic therapy via the clonogenic assay, we observed a …
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Nano- and Micro-Second Electrical Pulsing of B16-F10 Mouse Melanoma Cells: Plasma Membrane and Sub-Cellular Organelle Changes
… and 1.2 kV/cm, were applied to mouse melanoma B16-F10 cells. Two different ns durations (60 and 300 ns) with an electric field of 60 kV/cm and microsecond duration (100 µs) at 1.2 kV/cm were used in this study.</p> <p>Morphological changes on plasma membranes and cell organelles were analyzed …
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Attachment Ability and Melanoma Inhibitory Activity mRNA Expression Level Changes in Murine B16-F10 Melanoma Cells Post Nanosecond Electric Pulses
… three, and four 300 ns 40 kV/cm pulses to murine B16-F10 melanoma cells. Cell attachment ability was determined by comparing the number of floating cells and the percentage of attached cells. Melanoma inhibitory activity (MIA) is a secretory protein that is highly correlated with the malignancy …
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Efeito da inibição de Serine Arginine Protein Kinases (SRPKs) em modelo de melanoma murino subcutâneo
… a concentração de células de melanoma murino B16-F10 a serem inoculadas pela via subcutânea em camundongos C57BL/6, a fim de utilizar esse modelo animal padronizado nos próximos experimentos. Células B16-F10 nas concentrações de 1x10 5 , 2x10 5 e 4x10 5 células foram inoculadas no dorso de …
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The role of lymph node-derived lymphatic endothelial cells in immune modulation in the tumour microenvironment
… dendritic cell (DC) mediated immunity. Using the B16-F10 melanoma model, this work confirmed expansion of TDLN-LECs prior to metastasis and demonstrated transcriptional reprogramming of immune-associated pathways in LECs isolated from early TDLNs. This was accompanied by differentially localized …
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Formulation of non-ionic surfactant vesicles for therapeutic delivery of siRNA in cancer treatment
… cancer cells (A780), and mouse melanoma cells (B16-F10-LUC). These experiments were carried out with the use of normal human prostate cells PNT2) as a control. The used cancer cell lines were selected as they are among the most abundant cancers types worldwide. Cytotoxicity studies indicated …
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Treatment of murine tumors with recombinant Myxoma viruses
… (MYXV:Tomato). These studies indicated that B16-F10 melanoma cells were fully-permissive to MYXV infection, while GL261 glioma cells were partially permissive, and EL4 cells were non-permissive. All stages of virus morphology were observed in the permissive cells and there was evidence of …
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Implicación de las quiomicinas CCL2 CCL5 en modelos de dolor neoplásico experimental.
… por la inoculación de las células de melanoma B16-F10. Finalmente, el bloqueo de los CCR2 espinales inhibe la hiperalgesia derivada de la administración del antineoplásico paclitaxel. El aumento espinal de CCL2, relacionado con la activación de microglía, podría justificar este efecto.
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Potentiation of The Immune Checkpoint Blockade Response By Metabolic Modulation Is Predictable Using Molecular Imaging
… T cell activation. However, the change in B16-F10 pHe after esomeprazole predicts response to combination therapy, whose increase is compensated by increased myeloid cell infiltration. Myo-inositol trispyrophosphate (ITPP), increases oxygen release into the TME of CT26 and 4T1 tumors, …
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Mechanismen der CD8+ T-Zell-vermittelten Tumorabwehr beim B16 Melanom der Maus
… von CD8+ T-Zellen zu untersuchen, wurden murine B16.F10 Melanomzellen verwendet, die mit einem Minigen des immundominanten CD8+ T-Zell-Epitop (GP33) vom Glykoprotein des Lymphozytären Choriomeningitis Virus (LCMV) transfiziert worden waren (Prévost-Blondel et al., 1998). Weiterhin wurden …
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Zein-based nanoparticles for drug delivery applications
… a model hydrophobic substance, Nile red, into B16-F10-luc-G5 melanoma cells in a time-dependent manner, with higher cellular uptake observed when using smaller chain length PEG5K and lower PEG density. The impact of the protein corona on the uptake of PEGylated zein micelles by cancer cells and …
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Design and development of an RNA vaccine against tumor-mediated angiogenesis and metastasis targeting a KLH-Adrenomedullin fusion protein
… as a negative control. After five immunizations, B16- F10 melanoma cells were injected through the tail vein to induce lung metastases. In addition, transgenic mice expressing green fluorescent protein in the blood vessels (SMAA-GFP) were also immunized with both LNP types to assess the effect of …
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Development of non-ionic surfactant vesicles for inhaled drug delivery
… screening of novel minor binders (MGBs) against B16 F10 cells and L. donovani identified potential lead compounds. Studies in a murine model of V visceral leishmaniasis showed that intravenous administration of MGB58 encapsulated within NIVs reduced the parasite burdens in the liver (p ≤ 0.05). …
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Development of an oral DNA anti-cancer vaccine targeting an angiogenic peptide, proadrenomedullin N-terminal 20 peptide (PAMP)
… the ghosts five times at 2-week intervals. Then, B16-F10 melanoma cells were injected either into the tail vein to generate lung metastases or subcutaneously to generate cutaneous melanoma. Furthermore, naive CD4+ T cells were exposed to PAMP, and their secretome was analyzed by proximity …
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Novel Perspectives on the Utilization of Chemotactic Salmonella Typhimurium VNP20009 as an Anticancer Agent
… the eukaryotic transcriptome. We employed the B16-F10 mouse melanoma model because VNP20009 is known to colonize and eradicate these tumors in mice. First, we optimized a timeline for Salmonella treatment of mouse melanoma, finding a dramatic delay in tumor growth between 2 and 7 days due to …
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Interrogating the functional adaptions of Tumour-draining lymph nodes (TDLNs) and the subsequent impact of checkpoint inhibition
… requires further exploration. Utilising the B16-F10 melanoma and E0771 breast cancer (BC) model I identified significant changes in the T cell landscape of TDLNs. While the CD8-mediated immune response is effectively suppressed in TDLNs, the CD4 compartment undergoes dramatic alterations. …
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Defining the pro-tumour impact of the evolving stromal microenvironment
… To avoid bias, CAFs were isolated from the B16-F10 melanoma model using a ‘negative selection’ approach. Our data revealed the presence of 3 functionally distinct fibroblast populations, termed ‘immune’, ‘desmoplastic’ and ‘contractile’, which expressed genes involved in immune cross talk, …
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Modelling and Investigation of Drug and Immune Therapies for Cancer
… Mattes et al, show that the tumour (i.e., B16-OVA melanoma) is eliminated by Th1 cells, but Th2 cells reduce the size of tu- mour (i.e., not eliminate the tumour cells). However, Xie et al show that the tumour B16 cells are eliminated by Th1 cells. Moreover, Kobayashi et al show that the …
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Meeting the challenges: carbon-hydrogen bond activation and cancer treatment
… hyperthermia proved to be very effective against B16-F10 mouse melanomas in Charles River black mice. After hyperthermia, the nanoparticles have shown a significant effect on the growth of tumor (up to 78% growth inhibition).
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Preparation and analysis of novel tumour-targeted delivery systems for prostate cancer therapy
… of 60% of A431 tumours and up to 50% of B16-F10 tumours over one month. The treatment was well tolerated by the animals, with no apparent signs of toxicity.To our knowledge, it is the first time that an intravenously administered non-viral gene therapeutic system led to growth inhibition …
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