Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"B16 melanoma"”.
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Interferon-gamma suppresses melanogenesis in B16 melanoma cells and primary human melanocytes
… the underlying mechanism involved in it. Using B16 melanoma cell lines and primary human melanocytes, I demonstrated that alpha-MSH induced tyrosinase expression and activity and TRP-1, TRP-2 expression were suppressed by IFN-γ, which resulted from the inhibition of MITF expression, upstream …
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The antitumor activity of tumor-targeted RNA replicase-based plasmid DNA
… with model tumors (TC-1 lung cancer cells or B16 melanoma cells) and compared it to a traditional pCMV-beta plasmid. In cell culture, transfection of tumor cells with pSIN-beta generated dsRNA. In mice with model tumors, pSIN-beta more effectively inhibited tumor growth than pCMV-beta, and in …
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Harnessing DNA nanoarchitecture to overcome immunoevasion in cancer
… Delivery of G3YSD-encoding dendrons to murine B16 melanoma significantly increased the expression of major histocompatibility complex I (MHC I) and programmed cell death-ligand 1 (PD-L1) surface-bound receptors, which are critical for immune signaling pathways. The chemical conjugation of …
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Structures of the Didemnins (Antiviral, Antitumor, Compounds)
… to 199 vs. P388 leukemia, and T/C up to 160 vs. B16 melanoma.
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Impact of delta-tocotrienol on human melanoma cell proliferation
… suppresses the proliferation of marine B16 melanoma cells and human blood, breast, cervix, colon, liver, lung, lymph gland, nerve, pancreas, and prostate tumor cells. Dietary d-δ-tocotrienol suppresses the growth of implanted B16 melanomas without toxicity to host mice. We evaluated the …
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The impacts of psychological stress on innate-like invariant T cell survival, phenotype, and function
… mice fail to prevent pulmonary metastases of B16 melanoma. MAIT cells also upregulate TIGIT and are incapable of mounting optimal TH1- and TH2-type responses during stress. Lastly, these inhibitory effects are not simply due to cell death since human and mouse iNKT and MAIT cells are unusually …
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Il-1Α Blockade Reduces Immune Suppression In The Early Tumor Micro-Environment
… Gregory Lizee, PhD.</p> <p>Immunotherapy against melanoma has shown great promise in the clinic for treating advanced-stage patients. However, a major barrier against effective T cell mediated cytotoxicity is immunosuppression in the tumor micro-environment. It has been described that tumors …
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Interleukin-15 and [alpha](1,3)galactosyl-expressing vaccine combination therapy for melanoma
… knockout (alphaGT KO) mouse model and B16 melanoma cells genetically modified to express alphaGal epitopes (B16alphaGal). In this model, the B16alphaGal vaccine showed efficacy in treating pre-existing subcutaneous and pulmonary alphaGal-negative B16 melanomas in mice. Furthermore, …
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Tumor Immunotherapy: Mechanisms of Acquired Resistance and Characterization of Immune Related to xicities
… responses, we established a murine model of melanoma designed to elucidate the molecular mechanisms underlying immunotherapy resistance. Through multiple in vivo passages, we selected a B16 melanoma tumor line that evolved complete resistance to combination blockade of CTLA-4, PD-1, and …
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The Cytoplasmic Tail of Mhc Class I Molecules Plays A Critical Role In Dendritic Cell-Induced T Cell Immunity
… DCs. These DCs were then used as vaccines in a melanoma mouse tumor model and in a human invitro co-culture system.</p> <p>In this thesis, we show that DCs expressing exon 7-deleted MHC-I molecules, stimulated remarkably higher levels of T-cell cytokine production and significantly increased the …
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Metabolic Factors Determining Outcome in Chemotherapy: Studies with Pazopanib
… the efficacy of pazopanib in a mouse derived B16 melanoma tumour growth study in vivo. Pazopanib retarded the growth of melanoma tumours in both wild-type and humanised CYP3A4/3A7/hCAR/hPXR mice. Overall survival was reduced in animals which has been induced using Aroclor-1254, which suggests …
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Modelling and Investigation of Drug and Immune Therapies for Cancer
… Mattes et al, show that the tumour (i.e., B16-OVA melanoma) is eliminated by Th1 cells, but Th2 cells reduce the size of tu- mour (i.e., not eliminate the tumour cells). However, Xie et al show that the tumour B16 cells are eliminated by Th1 cells. Moreover, Kobayashi et al show that the …
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The effects of the modification of energy metabolism on cellular response to ionizing radiation
… to repair. Experiments were conducted using B16 melanoma cells in vitro and using normal murine liver and CaNT tumours in vivo. ATP concentration was measured in extracts of these cells after irradiation using the luciferase-luciferin method. No major changes from unirradiated controls were …
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Investigation of ACE-overexpression in Myeloid Cell Lines through Whole-Proteome Analysis
… the ability to improve murine survival against B16 melanoma, methicillin-resistant Staphylococcus aureus (MRSA) and Listeria monocytogenes. Current literature points to the C-domain as the main proponent. The myeloid cells have enhanced reactive oxygen species (ROS) generation, pro-inflammatory …
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Development of inducible transgenic mouse models for melanoma
… the past decades, the molecular mechanism(s) of melanoma development remains largely unknown. Therefore the purpose of this project was to establish a transgenic mouse model able to investigate the molecular mechanism(s) of melanoma aetiology mediated by N-Ras and PTEN genes. To achieve this, an …
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Peptide Vaccine Formulation Controls The Duration of Antigen Presentation and Magnitude of Tumor‐Specific Cd8+ T Cell Response
<p>Despite remarkable progresses in vaccinology, therapeutic cancer vaccines have not achieved their full potential. We previously showed that the duration of antigen presentation critically affected the quantity and quality of T cell response and subsequent anti‐tumor efficacy. Here we describe …