Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"B16"”.
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Mechanismen der CD8+ T-Zell-vermittelten Tumorabwehr beim B16 Melanom der Maus
… von CD8+ T-Zellen zu untersuchen, wurden murine B16.F10 Melanomzellen verwendet, die mit einem Minigen des immundominanten CD8+ T-Zell-Epitop (GP33) vom Glykoprotein des Lymphozytären Choriomeningitis Virus (LCMV) transfiziert worden waren (Prévost-Blondel et al., 1998). Weiterhin wurden …
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Interferon-gamma suppresses melanogenesis in B16 melanoma cells and primary human melanocytes
… the underlying mechanism involved in it. Using B16 melanoma cell lines and primary human melanocytes, I demonstrated that alpha-MSH induced tyrosinase expression and activity and TRP-1, TRP-2 expression were suppressed by IFN-γ, which resulted from the inhibition of MITF expression, upstream …
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Photofrin-Mediated Electroporation-Assisted Photodynamic Therapy of MCF-7 Human Breast Cancer and B16-F10 Mouse Melanoma Cells
… Photofrin content in both MCF-7 and B16-F10 cell lines in those samples subjected to electroporation and an equal Photofrin concentration compared to the non-electroporated samples. In evaluating the cytotoxicity of photodynamic therapy via the clonogenic assay, we observed a …
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Nano- and Micro-Second Electrical Pulsing of B16-F10 Mouse Melanoma Cells: Plasma Membrane and Sub-Cellular Organelle Changes
… and 1.2 kV/cm, were applied to mouse melanoma B16-F10 cells. Two different ns durations (60 and 300 ns) with an electric field of 60 kV/cm and microsecond duration (100 µs) at 1.2 kV/cm were used in this study.</p> <p>Morphological changes on plasma membranes and cell organelles were analyzed …
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Attachment Ability and Melanoma Inhibitory Activity mRNA Expression Level Changes in Murine B16-F10 Melanoma Cells Post Nanosecond Electric Pulses
… three, and four 300 ns 40 kV/cm pulses to murine B16-F10 melanoma cells. Cell attachment ability was determined by comparing the number of floating cells and the percentage of attached cells. Melanoma inhibitory activity (MIA) is a secretory protein that is highly correlated with the malignancy …
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Interleukin-15 and [alpha](1,3)galactosyl-expressing vaccine combination therapy for melanoma
… knockout (alphaGT KO) mouse model and B16 melanoma cells genetically modified to express alphaGal epitopes (B16alphaGal). In this model, the B16alphaGal vaccine showed efficacy in treating pre-existing subcutaneous and pulmonary alphaGal-negative B16 melanomas in mice. Furthermore, …
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N-[2-(Diethylamino)ethyl]benzamide als melanomaffine Trägermoleküle für Zytostatika und Gadoliniumkomplexe
… charakterisiert und ihre IC50-Werte für murine B16 Melanomzellen, SkMel 28 (humane Melanomzellen), Mausfibroblasten, MH3924A (Morris Hepatom) und HeLa (humanes Zervixkarzinom) ermittelt. Alle Chlorambucilkonjugate und 3 von 5 Chlorambucilanaloga erwiesen sich für jede der getesteten Zellinien …
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The antitumor activity of tumor-targeted RNA replicase-based plasmid DNA
… with model tumors (TC-1 lung cancer cells or B16 melanoma cells) and compared it to a traditional pCMV-beta plasmid. In cell culture, transfection of tumor cells with pSIN-beta generated dsRNA. In mice with model tumors, pSIN-beta more effectively inhibited tumor growth than pCMV-beta, and in …
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Modelling and Investigation of Drug and Immune Therapies for Cancer
… Mattes et al, show that the tumour (i.e., B16-OVA melanoma) is eliminated by Th1 cells, but Th2 cells reduce the size of tu- mour (i.e., not eliminate the tumour cells). However, Xie et al show that the tumour B16 cells are eliminated by Th1 cells. Moreover, Kobayashi et al show that the …
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The characterisation of a recombinant cytosolic shuttle based on ricin toxin
… of RTAC mutants was characterised in vitro (B16 and Vero cells) using the MTT assay. Using the B16 cell model, at concentrations up to10g/mL, no IC50 values could be established for rRTAC (clone 189). The published wild type RTAC IC50 was 1.4g/mL in B16 cells. The aforementioned rRTAC …
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Impact of delta-tocotrienol on human melanoma cell proliferation
… suppresses the proliferation of marine B16 melanoma cells and human blood, breast, cervix, colon, liver, lung, lymph gland, nerve, pancreas, and prostate tumor cells. Dietary d-δ-tocotrienol suppresses the growth of implanted B16 melanomas without toxicity to host mice. We evaluated the …
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The potential role of interleukin-2 in impaired cell-mediated immunity of iron deficiency
… in the weanling Sprague-Dawley rat and C57/B16 mouse were used as the nutritional models.
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Efeito da inibição de Serine Arginine Protein Kinases (SRPKs) em modelo de melanoma murino subcutâneo
… a concentração de células de melanoma murino B16-F10 a serem inoculadas pela via subcutânea em camundongos C57BL/6, a fim de utilizar esse modelo animal padronizado nos próximos experimentos. Células B16-F10 nas concentrações de 1x10 5 , 2x10 5 e 4x10 5 células foram inoculadas no dorso de …
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The effects of the modification of energy metabolism on cellular response to ionizing radiation
… to repair. Experiments were conducted using B16 melanoma cells in vitro and using normal murine liver and CaNT tumours in vivo. ATP concentration was measured in extracts of these cells after irradiation using the luciferase-luciferin method. No major changes from unirradiated controls were …
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Harnessing DNA nanoarchitecture to overcome immunoevasion in cancer
… Delivery of G3YSD-encoding dendrons to murine B16 melanoma significantly increased the expression of major histocompatibility complex I (MHC I) and programmed cell death-ligand 1 (PD-L1) surface-bound receptors, which are critical for immune signaling pathways. The chemical conjugation of …
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The role of lymph node-derived lymphatic endothelial cells in immune modulation in the tumour microenvironment
… dendritic cell (DC) mediated immunity. Using the B16-F10 melanoma model, this work confirmed expansion of TDLN-LECs prior to metastasis and demonstrated transcriptional reprogramming of immune-associated pathways in LECs isolated from early TDLNs. This was accompanied by differentially localized …
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New positioning system for the CSL Robotics Laboratory Testbed
A new positioning system is proposed for the B16 Robotics Laboratory testbed. The system is vision based and distributed. Each mobile agent is responsible for solving its individual positioning problem. The modified algorithm implements detection and identification techniques for position markers, …
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Formulation of non-ionic surfactant vesicles for therapeutic delivery of siRNA in cancer treatment
… cancer cells (A780), and mouse melanoma cells (B16-F10-LUC). These experiments were carried out with the use of normal human prostate cells PNT2) as a control. The used cancer cell lines were selected as they are among the most abundant cancers types worldwide. Cytotoxicity studies indicated …
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Treatment of murine tumors with recombinant Myxoma viruses
… (MYXV:Tomato). These studies indicated that B16-F10 melanoma cells were fully-permissive to MYXV infection, while GL261 glioma cells were partially permissive, and EL4 cells were non-permissive. All stages of virus morphology were observed in the permissive cells and there was evidence of …
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