Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"B1 receptor"”.
-
Role of kinins in mediating vascular function in healthy pregnancy and pre-eclampsia
… it was hypothesised that alterations of kinin receptor-mediated responses may be involved in the pathogenesis of the condition. To investigate whether changes in kinin receptor activity are involved in the impairment of endothelium-dependent relaxation observed in pre-eclampsia, the effects of …
-
Inflammation, kinins, and kinin receptors
… activation of the constitutively expressed B2 receptor, which desensitizes and is internalized upon ligand binding. The kininase I metabolite of BK, desArg9BK, on the other hand mediates chronic deleterious inflammatory responses by interacting with the B1 receptor. Although normally absent, B1 …
-
The effects of bradykinin and angiotensin II on the thoracic aorta vasa sasorum microcirculation system
… of ANG II and BK, their antagonists (AT 2 receptor antagonist PD 123319, AT1 receptor antagonist EXP3174, B2 receptor antagonist HOE 140, B1 receptor antagonist (Leu9 ) Des Arg 10- KD (1 ?M), and nitric oxide synthase inhibitor L-NAME."--Résumé abrégé par UMI
-
Kinin System Activation in Vasculitis
… PR3-kinin binds to and activates kinin B1-receptors both in vitro and in vivo. In addition, PR3-ANCAs from patients with vasculitides inhibit PR3-induced HK proteolysis and subsequent PR3-kinin release. In the MRLlpr/lpr mouse, that develops systemic inflammation and vasculitis, we …
-
Role of Macrophages in Ocular Surface Fibrosis
… notable increase in RAS components and TGF-b1 receptor, but no change in PDGF and M-CSF expression was noted. Finally, our data demonstrates that both M1 and M2 macrophages showed increased gene expression and secretion of chemokines CCL17 and CCL22.</p> <p>In conclusion, our data …
-
G protein-coupled receptor regulation: The role of protein interactions and receptor trafficking
The superfamily of G protein-coupled receptors (GPCR) is the largest gene family in the human genome. GPCR-mediated signaling operates in every human cell, and about 50% of existing clinically useful drugs act through GPCR. Kinins are proinflammatory peptides that are rapidly produced …