Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"B-lymphoma"”.
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Immune modulating functions by soypeptide lunasin in cancer immunotherapy
… Our previous studies demonstrate that lymphoma patients are refractory to clinical immunotherapy because of chemotherapy-induced immune dysfunction. In addition, tumors can induce immune suppression, which allows them to escape immunosurveillance. Thus, it is prudent to develop an …
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Presentation Of Citrullinated Peptides Derived From Unmodified Protein By Antigen Presenting Cells.
… with HEL or from HEL transgenic mice or from a B lymphoma line. The reported localization of the enzymes that convert peptidylarginine to peptidylcitrulline is either the cytosol or nucleus and not in antigen processing and loading compartments. The role of autophagy, or the mechanism by which …
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Hdm2 Small-Molecule Inhibitors For Therapeutic Intervention In B-Cell Lymphoma
<p>Lymphomas frequently retain wild-type (wt) p53 function but overexpress HDM2, compromising p53 activity. Therefore, lymphoma is a suitable model for studying therapeutic value of disrupting HDM2-p53 association by small-molecule inhibitors (SMIs). HDM2 SMIs have been developed and are currently …
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Understanding the Mechanism of Action of Rituximab in the Reversal of Multidrug Resistance in a Non-Hodgkins Lymphoma Cell Line
… monoclonal antibody (MAb) can reverse MDR in B lymphoma cells in vitro. However, the mechanisms underlying this effect are unknown. A recent study showed that anti-CD20 MAbs could induce rapid redistribution of CD20 into a detergent-insoluble embrane compartment (lipid rafts). By redistributing …
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Elucidating the Role of BMI1 in Lung and Colon Tumor Maintenance and Progression
… to specifically target and eradicate CSCs. B lymphoma Mo-MLV insertion region 1 homolog (BMI1) is an epigenetic regulator important for stem cell self-renewal and differentiation, and it is also a proto-oncogene that is overexpressed in a wide variety of cancer types. Given its role in normal …
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Roles for the polycomb group protein BMI1 in lung adenocarcinoma progression and maintenance
The B lymphoma Mo-MLV insertion region 1 homolog (Bmil) protein is implicated as an oncogene in a variety of human cancers. During normal development, Bmil acts as part of a transcriptional repressive complex that regulates processes such as stem cell self-renewal, cell-fate commitment, and …
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Μελέτη ρυθμιστών του κυτταρικού κύκλου και παραγόντων που εμπλέκονται στη διεργασία αποδόμησης των P21cip1 και P27kip1 σε λεμφώματα Β-κυτταρικής αρχής. Συσχέτιση με κλινικές παραμέτρους
Κατά τη διάρκεια του κυτταρικού κύκλου ένας από τους σημαντικότερους μηχανισμούς ρύθμισης της ομοιόστασης των πρωτεϊνικών μορίων είναι η ελεγχόμενη στο χώρο και στο χρόνο αποδόμηση τους. Οποιαδήποτε ανωμαλία στη ρύθμιση των μηχανισμών αποδόμησης των πρωτεϊνών μπορεί να προκαλέσει σημαντική βλάβη …