Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"B-cell lymphoma-2"”.
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Microrna 21 targets B Cell Lymphoma 2 (Bcl2) Mrna to increase beta cell apoptosis and exosomal Microrna 21 could serve as a biomarker of developing Type 1 Diabetes Mellitus
The role of beta cell miR-21 in Type 1 Diabetes (T1D) pathophysiology has been controversial. Here, we sought to define the context of beta cell miR-21 upregulation in T1D and the phenotype of beta cell miR-21 overexpression through target identification. Furthermore, we sought to identify whether …
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C-Jun N-Terminal Kinases Regulate Adenovirus-Mediated Autophagy and Antigen Presentation
… molecular regulation of autophagy in infected cells remains under investigation. Our data suggested the canonical pathway regulating starvation-induced autophagy was not implemented in adenovirus-induced autophagy; however, adenovirus infection triggered phosphorylation of c-Jun N-terminal …
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Mechanisms of BAK Activation in the Initiation of Mitochondrial Apoptosis
… and adult homeostasis being regulated by B-Cell Lymphoma-2 (BCL-2) proteins. Deregulation of BCL-2 proteins form the basis for myriad of human pathologies including cancer and autoimmune diseases. Therefore, BCL-2 proteins are considered key therapeutic targets. BCL-2 homologous …
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Insulin-like growth factor 1 effects on mitochondrial dynamics and mitophagy in cancer
… for mitochondrial homeostasis in tumour cells remains mostly unknown. Mitochondria are key organelles for energy production, and, therefore, cancer cells rely on mitochondrial maintenance to support rapid cell proliferation. In this thesis, the effects of IGF-1 signalling on mitochondrial …
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Targeted 177 Lu antisense radiotherapy of B-cell non-Hodgkin's lymphoma
… OF MISSOURI-COLUMBIA AT AUTHOR'S REQUEST.] The B-cell lymphoma/leukemia-2 (bcl-2) proto-oncogene in non-Hodgkin's lymphoma (NHL) is a dominant inhibitor of apoptosis. The research goal was to develop a [superscript 177]Lu-labeled bcl-2 antisense peptide nucleic acid (PNA)-peptide conjugate …
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Investigations of equine sarcoids and bovine papillomavirus in Western Canada
… Caspase 3(ClC3), and antiapoptotic factors, B-Cell Lymphoma 2 (Bcl-2) and Survivin. No differences in the expression of any of these markers regardless of BPV type were noted. Survivin was expressed in equine sarcoids of all types and increased levels of expression are associated with more …
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Induction of death in myeloid leukaemia cells by doxorubicin and betulinic acid, singly and in combination was associated with the regulation of apoptosis, autophagy and the PI3K/Akt pathways
Relapsed acute myeloid leukaemia (AML) cells are difficult to eradicate due to their more refractory nature. Deregulation of the B-cell lymphoma 2 (Bcl-2) family of proteins in these cells, which regulates cell death through apoptosis, autophagy and other cell processes, may contribute to this …