Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 65 for “"B-cell Development"”.
-
An alternative B cell development program
Two major types of B cells, the antibody-producing cells of the immune system, are classically distinguished in the spleen: marginal zone (MZ) and follicular (FO). In addition, FO B cells are subdivided into FO I and FO II cells, based on the amount of surface IgM. MZ B cells, which surround the …
-
ELUCIDATING REGULATORY NETWORKS PROMOTING B-CELL DEVELOPMENT
B-cells are an essential part of our adaptive immune system. A network of transcription factors together with external signals facilitate the gradual developmental progression from progenitor cells towards the B-cell fate. Several key factors participating in this network have been identified. …
-
STUDIES OF B CELL DEVELOPMENT AND V(D)J RECOMBINATION
… to produce antibodies is restricted to the B cell lineage and is tightly regulated, starting with the temporal separation of the recombination process, in which DH-JH precedes VH-DHJH recombination. Successful recombination of both heavy and light chain loci results in the expression of an …
-
Investigation of IGF1R/IRS1 Signalling Mechanisms in B Cell Development
… declines as we age. This includes reduction in B cell number and function, contributing to increased vulnerability to infection in the elderly. Current evidence is consistent with age-associated defects emerging during early B cell development in the bone marrow (BM). Here, B cells develop by …
-
Heterogeneity and Impaired IGF1R Signalling in Aged B cell Development
B cells are a vital component of humoral immunity. Upon activation, their immunoglobulin B cell receptor (BCR) is secreted as antibody to neutralise pathogens or mediate the immune response. A diverse repertoire of immunoglobulin molecules is therefore essential for immune surveillance. As we age …
-
B-cell development and function in the absence of the spleen
… mice to study the function of the spleen for the development of B cells and the immune response to streptococcal polysaccharides. The absence of the spleen is not associated with a defect in the generation of mature B cells, but B-1a cells are severely reduced. Transfer of Hox11-/- fetal liver …
-
The Role of Foxo Transcription Factors in B Cell Development and Activation
… system depends on a diverse, self tolerant B cell repertoire. Mature B cells distributed throughout secondary lymphoid organs respond to antigenic stimuli by dividing and differentiating into plasma cells and other effector cell types. Signaling from the B cell receptor (BCR) plays a critical …
-
The Dual Role of OCA-B in B Cell Development and Signaling
<p>OCA-B (Oct coactivator from B cells) is a B-cell specific coactivator of transcription that acts in conjunction with the ubiquitously expressed activator, OCT-1 or the B cell-restricted OCT-2. OCT-1 or OCT-2 can bind an upstream octamer element with the consensus sequence 5'-ATGCAAAT-3' in …
-
Investigation of the three dimensional organisation of the genome in B cell development
… antibody repertoires, occurs during B lymphocyte development in the bone marrow. The three dimensional conformations of the multimegabase murine immunoglobulin heavy chain (Igh) and immunoglobulin kappa chain (Igκ) loci must not only facilitate recombination between gene segments separated by up …
-
The endoplasmic reticulum chaperone ERdj4 is required for survival, glucose metabolism and B cell development
… trap mice were generated from embryonic stem cells harboring a gene trap cassette inserted into the ERdj4 locus. ERdj4 gene trap mice expressed hypomorphic levels of ERdj4 with a 10-100 fold reduction in all tissues and cell types examined. Approximately 30-50% of ERdj4 gene trap mice died …
-
Characterization of downstream target genes regulated by ABF-1 in different states of B cell development
… nodes, and appendix, as well as transformed B cells lines infected with Epstein-Barr virus. This study investigates the role of ABF-1 in regulating downstream target genes in the human mature B cell line RAJI, as well as the plasma cell line, ARH-77. Quantitative real-time polymerase chain …
-
Comparative Studies of TSLP and IL-7 in Normal Early Human Neonatal and Adult B Cell Development
… the role of cytokines in promoting human B cell development is important for understanding B cell leukemia and for developing strategies to restore B cell production that is lost during some therapies. The purpose of this study was to investigate the roles of the IL-7R ligands, thymic …
-
Spatial organisation of the immunoglobulin heavy chain locus and inter-chromosomal gene networks driving B cell development
… highly diverse repertoire is produced during B cell development in the bone marrow from the immunoglobulin heavy chain (Igh) and light chain (Igk and Igl) loci. The mouse Igh is a large (~3Mb) multigene locus that contains 195 variable (V), 10 diversity (D) and 4 joining (J) genes that undergo …
-
On the role of treml6 in B-1a B cell development And ICOS co-stimulation in adaptive immune responses against M. tuberculosis
TREM Rezeptoren sind aus infektionsimmunologischer Sicht von großem Interesse, da sie TLR Signale inhibieren bzw. verstärken können und somit in der Lage sind, inflammatorische Immunantworten zu regulieren. Diese Doktorarbeit untersucht die immunologische Funktion von murinem TLT-6 (Gen: treml6), …
-
The role of Fyn and B-cell expressed ADAM10 in early B cell development, germinal center formation and terminal B cell differentiation
… determine the role of Fyn kinase and ADAM10 in B cell biology. A disintegrin and metalloproteinase 10 (ADAM10) is a zinc dependent proteinase related to matrix metalloproteinases. ADAM10 has emerged as a key regulator of cellular processes by cleaving and shedding extracellular domains of multiple …
-
CD21 and CD24 Co-expression: A Translational Model between Mouse and Human
… Erythematosus and Rheumatoid Arthritis are B cell-mediated autoimmune diseases that afflict millions of people worldwide. B cell-targeted therapies for these diseases result in variable clinical outcomes. Thus, a need exists to better understand the dynamics of human B cell production and …
Page 1 of 4