Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"B-RAF"”.
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Roles For B-Raf Kinase In The Specific Regulation of Α4Β1 Integrin In T Cells
… proteins and mediate T cell migration and trafficking by binding to ECM or other cells, as well as initiating intracellular signaling cascades promoting survival or activation. The mitogen activated-protein kinase (MAPK) pathway is known to be downstream from integrins and regulate survival, …
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Mouse Oocyte Maturation and Embryo Development After Exposure to Vemurafenib (PLX4032), an Anti-Melanoma B-RAF V600E Inhibitor
<p>Vemurafenib is a selective B-Raf<sup>V600E</sup> inhibitor in melanoma targeted therapy which also inhibits the wild type B- and C-Raf. In oocyte maturation, the C-Raf/MAPK pathway acts as an important self-enhancing and promoting system, w hereas in embryo development, the C-Raf/M APK pathway …
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The Role of Raf-mediated Signalling Pathways for Motoneuron
… of intracellular signalling proteins. The Ras/Raf/MEK/MAPK signalling pathway has been shown to control the expression of genes which are crucial for the physiological regulation of cell proliferation, differentiation and apoptosis. Within this signalling cascade, the Raf protein family of …
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Genomweite Suche neuer Modulatoren der Signaltransduktion in kardialer Hypertrophie und Herzinsuffizienz
… Arbeit konnte erstmals gezeigt werden, dass B-Raf in der Regulation kardialer Hypertrophie eine Rolle spielt. Um dies zu ermitteln, wurde im Modell kultivierter neonataler Kardiomyocyten der Ratte, die Zellgröße planimetrisch untersucht. Die Zellen wurden dabei mittels Phenylephrin zur …
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Role of Raf family members in mouse development
Raf Proteine sind Serin/Threonin Kinasen, die als zentrale Elemente des Ras, Raf, Mek, Map Kinase Wegs, an der Weiterleitung von extrazellulären Signalen von der Zellmembran zu nukleären Effektoren beteiligt sind. Auf diese Weise kontrollieren sie elementare Prozesse wie Proliferation, …
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Design, Synthesis, and Biological Screening of Novel Cucurbitacin/ Estrone Analogs Towards Treatment of Melanoma
… causing about 75 % of skin cancer deaths. B-Raf mutations show high incidence in melanoma. Inhibition of Mitogen Activated Protein Kinase (MAPK) signal transduction pathway can subsequently lead to induce apoptosis assisting in the treatment of melanoma. Initially, the binding affinity of …
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The crosstalk between the ERK and the cAMP signalling pathways in PC12 Cells
… indicating that cAMP can switch on the Rap1/B-Raf pathway. This correlated with the increase in the phosphorylation of ERK in response to high levels of cAMP upon EGF stimulation. Then, the role of Raf-1 and C3G, a guanine exchange factor for Rap1, were investigated using small interfering RNA. …
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Kartierung krebsrelevanter Signalwege
… und Apoptose beteiligt. Proteinkinasen der Raf-Familie wirken dort als signalübertragende Elemente, welche Membranrezeptoren nachgeschaltet sind. Diese Proteine fungieren als Proto-Onkogene, eine Veränderung dieser Proteine kann sie in Onkogene überführen und sind wesentlich an der …
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Lmw-E Mediates Mammary Tumorigenesis By Deregulating Acinar Morphogenesis & Generating Cancer Stem Cells
… reveals that the</p> <p>activation of the b-Raf-ERK1/2-mTOR pathway in concert with high LMW-E</p> <p>expression predicts poor patient survival. Combination treatment using roscovitine</p> <p>(CDK inhibitor) plus either rapamycin (mTOR inhibitor) or sorafenib (b-raf inhibitor)</p> …
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Molecular control of endothelial lumen formation by Rho GTPases in three dimensional collagen matrices
… 3D collagen matrices. Pak2 and Pak4 activate two Raf kinases, B-raf and C-raf, to induce EC lumen formation. Further examination of Raf kinase signaling reveals that regulation of EC lumen formation in 3D collagen matrices depends on ERK signaling. This data reveals a coordinated kinase signaling …
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Understanding and Targeting the FGF-2/S6K2 Signal Pathway in Small Cell Lung Cancer Towards the Development of Novel Anti-Cancer Treatments.
… complex forms consisting of three kinases – B-Raf, Protein Kinase C epsilon (PKCε) and Ribosomal S6 Kinase Beta II (S6K2) – resulting in the activation of the latter. S6K2 then phosphorylates the nucleic acid binding protein Heterogeneous Nuclear Ribonucleoprotein A1 (hnRNP A1) at serines 4 and …
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A Translational Study Evaluating the Uses of Diagnostic and Therapeutic Practices Established in Human Malignant Melanoma in Equine Malignant Melanoma
… immunohistochemical staining. Nestin, Pax-3/7, B-Raf, and SOX-10 are commonly expressed in HMM tissues. Expression of these proteins is not noted in normal human melanocytes, is associated with decreased melanocytic differentiation, and with increased proliferation leading to tumorigenesis. My …
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B cell signalling in mechanisms of central and peripheral tolerance
… in full. For example, in B cells, the Ras/Raf-1/MEK cascade is considered to be a major pathway regulating ERK activation and consistent with this, this laboratory has previously shown that overexpression of Ras can rescue WEHI-231 B cells from BCR-mediated growth arrest. However, although …
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Investigating the Role of Complex I Loss in Thyroid Tumorigenesis
… thyroid cancer, driven universally by the BRAF V600E activating mutation. I have developed a murine model of Braf-driven thyroid cancer to investigate the role of Complex I loss in both tumor initiation and progression.
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Development of inducible transgenic mouse models for melanoma
… and mechanisms of other genes such as MITF, B-Raf, MC1R etc involved in the development of human melanoma.
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MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… been directed towards evaluation of the role of Raf-MEK-ERK1/2 signaling transducers in regulating the expression of pro-inflammatory mediators in cerebral vessels following both ischemia and hemorrhagic stroke. The work provides some clues to explaining beneficial effects observed with …