Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"B-ARRESTIN"”.
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The Role of B-Arrestin in Agonish-Induced Down-Regulation of the M1 mAChR
… 2006 Pharmaceutical Sciences THE ROLE OF â–ARRESTIN IN AGONIST-INDUCED DOWN-REGULATION OF THE M1 mAChR Chair: Darrell A. Jackson G protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors. They mediate diverse cell signaling pathways and therefore are currently …
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The Role of B-Arrestin in Agonish-Induced Down-Regulation of the M1 mAChR
… 2006 Pharmaceutical Sciences THE ROLE OF â–ARRESTIN IN AGONIST-INDUCED DOWN-REGULATION OF THE M1 mAChR Chair: Darrell A. Jackson G protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors. They mediate diverse cell signaling pathways and therefore are currently …
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Ligand Bias by the Endogenous Agonists of CCR7
… the G-protein coupled Receptor Kinase (GRK)/ b-arrestin system. CCL19 and CCL21 are endogenous agonists for the chemokine receptor CCR7. They are known to be equipotent in promoting Gi/o mediated calcium mobilization, chemotaxis and inhibition of adenylyl cyclase activity. Here we test the …
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G Protein-Coupled Receptor Signaling in Growth and Inflammation of Vascular Smooth Muscle
… is regulated after stimulation through b-arrestin signaling. Interestingly, in the presence of vascular distension injury, we saw decreased arterial wall GPR68 expression compared to controls after 30 minutes. Using a carotid artery ligation injury, which more adequately mimics vascular …
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Regulation of Weibel-Palade Body Exocytosis by alpha-Synuclein in Endothelial Cells
… by enhancing the interaction of RalGDS/b-arrestin complexes. Immuno-EM analysis revealed that a-synuclein was localized close to WPB. These findings imply that a-synuclein plays as a negative regulator in WPB exocytosis in endothelial cells.
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CANNABINOID RECEPTOR INTERACTING PROTEIN 1A (CRIP1A): EFFECTS ON CB1 RECEPTOR FUNCTION AND CELLULAR REGULATION
Cannabis, or marijuana, is the most commonly used illicit drug in the United States. The CB1 cannabinoid receptor (CB1R) has been extensively studied since the initial characterization of its involvement in mediating the psychotropic effects of marijuana. CB1R is one of the most abundantly …