Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"B-ALL"”.
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Modelling the effect of loss of function CREBBP mutations in the evolution and treatment of B cell acute lymphoblastic leukaemia (B-ALL)
… B cell acute lymphoblastic leukaemia (B-ALL) pathogenesis and the use of novel treatments, there are still some subtypes classified as high-risk patients and many other who relapse. In this thesis I seek to understand the role of CREBBP mutations in the context of B-ALL. These mutations …
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TSLP-induced Mechanisms and Potential Therapies for CRLF2 B-cell Acute Lymphoblastic Leukemia
… B-cell Acute Lymphoblastic Leukemia (CRLF2 B-ALL) is a high-risk form of leukemia that is associated with poor patient survival outcomes. CRLF2 B-ALL is five times more prevalent in Hispanic children than others and is associated with a higher rate of relapse, thus contributing significantly …
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PHF6 is a novel regulator of B-cell identity in acute lymphoblastic leukemia
… growth in B-cell acute lymphoblastic leukemia (B-ALL). To identify the mechanisms by which PHF6 acts to promote B-ALL growth in vivo, we utilized CRISPR-Cas9 to delete Phf6 in murine B-ALL cells. Transplantation of Phf6 knockout cells (Phf6KO) into immunocompetent recipients significantly extended …
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Effects of Pharmacological and Genetic Disruption of Chemokine Receptor Cxcr4 In B-Cell Acute Lymphoblastic Leukemia
… after conventional chemotherapy against B-ALL. Indeed, in this study we observed that B-ALL cells that had migrated beneath the BMSCs were highly resistant to chemotherapeutic drugs. Inhibition of CXCR4 to disrupt this interaction presents itself as an attractive target to overcome bone …
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Deconvolution of Leukemic Evolution Through Initiation, Progression and Relapse
… of B-cell acute lymphoblastic leukemia (B-ALL) have been made, but our understanding of the mechanisms of leukemic initiation and progression remain limited. To gain clarity on these processes, a deeper understanding of the co-operative role of genetic aberrations, the functional impact of …
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Functions of Novel Ligand-independent Flt3 Alleles and RANKL in Promoting Dissemination of Murine B-Cell Leukemias to the Central Nervous System
… pediatric B-cell acute lymphoblastic leukemia (B-ALL) have improved dramatically, but outcomes for the 15% who relapse and for adults with B-ALL remain poor. Up to 40% of pediatric B-ALL patients require central nervous system (CNS) prophylaxis that causes significant treatment-related …
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Role of ETV5 Mutations in B Cell Acute Lymphoblastic Leukemia
B cell acute lymphoblastic leukemia (B-ALL) develops through the acquisition of driver mutations that impair cell differentiation and promote proliferation. In human B-ALL, mutations in E26 transformation-specific (ETS) transcription factors are commonly reported. Our laboratory studies a mouse …
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Análise de Variantes Genéticas no gene da Endoglina em Leucemias Linfoblásticas Agudas de Células B Pediátricas
… in blasts in acute lymphoblastic leukemia (ALL) across different studies, and it is identified as a promising complementary diagnostic, prognostic, and therapeutic pathway. Therefore, this study examines the genetic variants rs11545664, rs35400405, and rs786514 in the ENG gene in pediatric …
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Elucidating oncogenic mechanisms in human B cell malignancies
… malignancies; Acute Lymphoblastic Leukaemia (ALL) and Diffuse Large B Cell Lymphoma (DLBCL). Firstly, Pre-B ALL represents the most common paediatric malignancy and despite increasingly improved outcomes for patients, ~ 20% of all patients diagnosed with ALL relapse. Activating mutations in …
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Analysis of B lymphocyte activation and differentiation by expression profiling
… in SLP65-/- mice could restore or at least partially rescue developmental blocks caused by the absence of SLP65 in B cells. The results revealed that both EGRxSLP65-/- and SLP65-/- B cells appear to be arrested at the same developmental (large pre-B cell) stage, suggesting that in the absence of …
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Towards a B-Lymphoid Model of E2A-PBX1-Mediated Leukemogenesis: Evaluating the Impact of Hematopoietic Cell of Origin on the Transformation Properties of a Leukemogenic Transcription Factor
… present in 5% of acute lymphoblastic leukemia (ALL) cases and leads to expression of the oncogenic transcription factor, E2A-PBX1. Although t(1;19) is exclusively associated with pre-B ALL in clinical cases, murine models produce myeloid or T-lymphoid leukemias, which are not representative of …
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Src-Kinasen als Mediatoren Bcr-Abl-induzierter Leukämien
… Fälle von akuter B-lymphoblastischer Leukämie (B-ALL) beteiligt. Die essentielle Rolle der Kinase-Aktivität von Bcr-Abl für dessen leukämogenes Potential konnte in zahlreichen Arbeiten demonstriert werden. Entsprechend ist Bcr-Abl Zielstruktur des ersten klinisch geprüften …
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A chromatin-modifying protein is a context-dependent modulator of cell survival in hematopoietic malignancies
… progression in a murine model of BCR-Abl+ B-ALL, a disease with low long-term survival rates despite treatment with inhibitors targeting the BCR-Abl kinase. This screen identified two chromatin-modifying genes, Chd8 and Sin3a, as necessary for growth and survival of leukemic cells. While …
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The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics
… dihydroartemisinin (DHA) translationally represses MCL-1 and synergizes with BH3-mimetics. To explore how DHA represses MCL-1, a genome-wide CRISPR screen identified that loss of genes in the heme synthesis pathway renders mouse BCR-ABL+ B-ALL cells resistant to DHA-induced death. …
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Genomics, Diagnosis, Novel Targeted Therapies and Characterisation of the Drivers of Relapse in Philadelphia Chromosome-Like Acute Lymphoblastic Leukaemia
… acute lymphoblastic leukaemia (Ph-like ALL), a subtype of B-cell ALL recently recognised as a distinct entity. The genomic drivers of Ph-like ALL are diverse. This thesis emphasises investigation of the JAK/STAT class of lesions. Ph-like ALL patients continue to have poor prognosis, in …
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Disposition of Cucurbitacin as a Factor in Host Plant Selection by Diabroticite Beetles and Electrophoretic Analysis of the Coevolved Genus Cucurbita
… host plant affinities produced an essentially identical array of metabolites when fed radio-labeled cucurbitacin B. All species excreted the bulk of the cucurbitacin (67.17-94.59% total dpm); permanently sequestered a small proportion of a cucurbitacin D conjugate in the hemolymph …
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Utilizing in vivo genome-wide CRISPR/Cas9 screens in immunocompetent mouse models to identify novel tumor liabilities and explore mechanisms of resistance to Chimeric Antigen Receptor T-cell therapy
… treatment for GBM reflects formidable challenges to therapeutic design including vast intra- and inter-tumoral heterogeneity, highly invasive growth patterns, and a hostile, immunosuppressive tumor microenvironment (TME). Fortunately, with the advent of CRISPR/Cas9 screening platform …
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Development and characterisation of a novel chimeric antigen receptor against LGR5
… receptor 5 (LGR5), a target gene of the Wnt signalling pathway, is lowly expressed in some stem cell niches and overexpressed in multiple cancers, including pre-B acute lymphoblastic leukaemia (pre-B ALL), hepatocellular carcinoma (HCC) and colorectal cancer (CRC). LGR5 has thus emerged as a …
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An Evaluation of the "How to Study" Instruction Given to Freshment AFROTC Cadets at Virginia Polytechnic Institute, Blacksburg, Virginia
… Twenty-five were sophomores and labeled Group B. All fifty responded in a voluntary and cooperative manner. Both positive and negative opinions were received.
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Characterizing The Source of Neutrophil Elastase and Proteinase 3 Cross-Presentation In B-Cell Acute Lymphoblastic Leukemia
… setting of anti-tumor immunity. We are specifically interested in possible roles of NETs in facilitating NE and P3 cross-presentation by acute lymphoblastic leukemia (ALL) due to its high abundance in the bone marrow.</p> <p>The major aim of this study was to validate PR1 as a target in B-ALL. …
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