Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"B-1 cells"”.
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Regulation of Protective B cell Anti-Tumor Responses
The role of B cells in tumor progression is complex and often overlooked. Specifically, little is known about the extent to which the specialized populations of innate-like B-1a and B-1b cells participate in and contribute to the anti-tumor immune response. The totality of work presented in this …
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PD-1 AND PD-1 LIGAND REGULATION OF NATURAL ANTIBODY SPECIFICITIES AND THE ADAPTIVE RESPONSE TO PNEUMOCOCCAL POLYSACCHARIDES
Interest in immuno-inhibitory receptors and their ligands has increased in the past three decades. Programmed cell death-1 (PD-1) is a surface-expressed receptor of the B7/CD28 superfamily and the subject of considerable study since its discovery in 1992 [1]. The available literature lacks an …
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Investigating the phenotype and function of tissue-resident B cells in mouse and human non-lymphoid organs
… functions. Studies to date have focused on B cells within blood and secondary lymphoid organs. This thesis sought to address the question of whether B cells reside in non-lymphoid organs (NLOs), and to determine their phenotype and function. Using intravenous labelling and parabiosis, we …
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PKB/Akt : a critical regulator of lymphocyte, development and function
… active form of PKBa (myr PKB) in T and B cells were analysed. Thymocytes from myr PKB tg mice showed enhanced proliferation after T cell receptor (TCR) engagement compared to wild type (wt) mice. Astonishingly, myr PKB tg thymocytes were capable to proliferate in response to PMA only and …