Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 101 for “"B lymphocytes"”.
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Investigating the antibody-independent functions of B lymphocytes
B cells are critical for the generation of antibody, but there is increasing evidence that they have a broader functional remit: For example, innate B1a cells are a critical source of granulocyte macrophage colony-stimulating factor (GM-CSF) during Gram-negative sepsis, inducing neutrophil …
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Gene Expression in Bovine Leukemia Virus-Infected B Lymphocytes
… chronic transforming retrovirus that infects B-lymphocytes and is associated with a long latency period. We studied the transcriptional activation of BLV in primary cells and also examined whether a measurable increase in BLV expression would effect the transcription of host genes. De novo …
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The Extent and Nature Of Chromosomal Rearrangements in B Lymphocytes
… obtained from 400 million activated B lymphocytes to two loci, IgH and c-myc. Our data and analysis reveal that proximity between DSBs, transcriptional activity and chromosome territories are key determinants of genome rearrangement. Specifically, rearrangements tend to occur in cis and …
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Molecular defects in B lymphocytes from patients with CVID- syndrome
… IgG. Transplantation of human peripheral blood lymphocytes of two CVID patients into the spleen of immunodeficient mice showed that the functional B cell integrity was restored in one patient after 21d, (as measured in terms of IgG production), whereas in the second patient the serum antibody …
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A Study of TGF‐β Signaling in B Lymphocytes and Glioblastoma
… the TGF–β cytostatic signaling pathway in B lymphocytes. TGF–β–induced growth inhibition is the most extensively studied biological response to a TGF–β signal. Although in most cell types this response is mediated by Smad3– dependent regulation of c–Myc, p15<super>Ink4B</super>, and …
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Modelling the affinity maturation of B lymphocytes in the germinal centre
… model to simulate the affinity maturation of B lymphocytes in the germinal centre in 3-D because certain behavioural aspects cannot currently be examined experimentally. The software tool recreates the structure of the germinal centre that enables the B cells to move and interact with other …
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TLR4 expression on equine B lymphocytes: a clue to LPS sensitivity?
… on equine B cells. TLR4 expression on B lymphocytes has been studied in mouse, human and many other mammals, but has not been well characterized in the horse. Humans are highly sensitive to LPS but their B cells express non-functional TLR4. Mice in contrast are highly tolerant of LPS yet …
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Molecular and functional analyses of human synovial B-lymphocytes in rheumatoid arthritis
B-cells of the rheumatoid synovial tissue are a constant part of and, in some histopathological subtypes, the dominant population of the inflammatory infiltrate, located in the region of tissue destruction. The pattern of B-cell distribution and the relationship to the corresponding …
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Influences of Host Cytokine Signaling on KSHV Infection in Tonsil-derived B Lymphocytes
… signaling influences KSHV infection in tonsil lymphocytes.</li> <li>Examine whether host cytokines influence B cell fate at early stages of KSHV infection</li> <li>Correlate baseline frequencies of immunological subsets, cells producing cytokines, and intracellular transcription factors with …
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Exploring neuro-immune interactions in neurodegeneration: the role of B lymphocytes in Parkinson’s disease
… progression, focusing on the contribution of B lymphocytes. These cells play a number of roles including antibody production, maintenance of subcapsular sinus macrophages, antigen presentation and regulation of T cell activity. Methods: I phenotyped peripheral blood B lymphocytes in 3 clinical …
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The Role of Id Proteins in the Development and Function of T and B Lymphocytes
<p>E and Id proteins are members of the basic helix-loop-helix (bHLH) transcription regulator family. These proteins control a broad range of lymphocyte biology, from the development of multiple lineages to execution of their effector functions. With the development of new experiment models, novel …
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Establishing the Role of DC-SIGN and Glycoprotein H for KSHV Entry in B Lymphocytes
… viral entry process of KSHV in tonsil-derived B lymphocytes. This study will particularly explore the role of KSHV glycoprotein gH and cell surface receptor DC-SIGN.</p> <p>The first aim of this project will investigate whether the cell surface receptor, DC-SIGN, is required for viral entry of …
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Characterization of a Novel Receptor CS1 in Human Lymphocytes; Studies in Natural Killer Cells and B-Lymphocytes
… was to investigate the roles of CS1 on human lymphocytes. The molecular and functional characterization of CS1 receptor in the natural killer (NK) cells and B lymphocytes was investigated. CS1 (CRACC, novel Ly9) is a novel member of the CD2 family receptor expressed on natural killer (NK), T …
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Taming a Potent Mutator: Identification and Characterization of Novel Mechanisms of Regulating Antibody Diversification in B-Lymphocytes
… virtually infinite array of foreign pathogens. Blymphocytes, the mediators of humoral immunity, have developed extensive mechanisms of gene diversification collectively known as antibody diversification. Antibody diversification, a set of processes necessary for an organism to mount a specific …
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ANALYSIS OF B LYMPHOCYTES IN MOUSE MODEL LIGASE IV WITH HYPOMORPHIC MUTATION IN VDJ RECOMBINATION ASSOCIATED WITH GROWTH DEFECT
The major mechanism for the repair of DNA doublestrand breaks (DSBs) in mammalian cells is non-homologous end-joining (NHEJ), a process that involves the DNA-dependent protein kinase , XRCC4 and DNA ligase IV. Rodent cells and mice defective in these components are radiation-sensitive and defective …
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