Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 110 for “"B lymphocytes"”.
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Investigating the antibody-independent functions of B lymphocytes
B cells are critical for the generation of antibody, but there is increasing evidence that they have a broader functional remit: For example, innate B1a cells are a critical source of granulocyte macrophage colony-stimulating factor (GM-CSF) during Gram-negative sepsis, inducing neutrophil …
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Gene Expression in Bovine Leukemia Virus-Infected B Lymphocytes
… chronic transforming retrovirus that infects B-lymphocytes and is associated with a long latency period. We studied the transcriptional activation of BLV in primary cells and also examined whether a measurable increase in BLV expression would effect the transcription of host genes. De novo …
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Antigen-specific depletion of autoreactive B lymphocytes in Multiple Sclerosis
… against self-antigens. Autoreactive B and T lymphocytes as well as activated macrophages and the bodies complement system contribute to, and maintain the inflammatory lesions in brain and spinal cord. For over 20 years, especially autoreactive T lymphocytes attracted major attention due to …
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The Extent and Nature Of Chromosomal Rearrangements in B Lymphocytes
… obtained from 400 million activated B lymphocytes to two loci, IgH and c-myc. Our data and analysis reveal that proximity between DSBs, transcriptional activity and chromosome territories are key determinants of genome rearrangement. Specifically, rearrangements tend to occur in cis and …
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Molecular defects in B lymphocytes from patients with CVID- syndrome
… IgG. Transplantation of human peripheral blood lymphocytes of two CVID patients into the spleen of immunodeficient mice showed that the functional B cell integrity was restored in one patient after 21d, (as measured in terms of IgG production), whereas in the second patient the serum antibody …
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A Study of TGF‐β Signaling in B Lymphocytes and Glioblastoma
… the TGF–β cytostatic signaling pathway in B lymphocytes. TGF–β–induced growth inhibition is the most extensively studied biological response to a TGF–β signal. Although in most cell types this response is mediated by Smad3– dependent regulation of c–Myc, p15<super>Ink4B</super>, and …
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Modelling the affinity maturation of B lymphocytes in the germinal centre
… model to simulate the affinity maturation of B lymphocytes in the germinal centre in 3-D because certain behavioural aspects cannot currently be examined experimentally. The software tool recreates the structure of the germinal centre that enables the B cells to move and interact with other …
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TLR4 expression on equine B lymphocytes: a clue to LPS sensitivity?
… on equine B cells. TLR4 expression on B lymphocytes has been studied in mouse, human and many other mammals, but has not been well characterized in the horse. Humans are highly sensitive to LPS but their B cells express non-functional TLR4. Mice in contrast are highly tolerant of LPS yet …
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Molecular and functional analyses of human synovial B-lymphocytes in rheumatoid arthritis
B-cells of the rheumatoid synovial tissue are a constant part of and, in some histopathological subtypes, the dominant population of the inflammatory infiltrate, located in the region of tissue destruction. The pattern of B-cell distribution and the relationship to the corresponding …
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Influences of Host Cytokine Signaling on KSHV Infection in Tonsil-derived B Lymphocytes
… signaling influences KSHV infection in tonsil lymphocytes.</li> <li>Examine whether host cytokines influence B cell fate at early stages of KSHV infection</li> <li>Correlate baseline frequencies of immunological subsets, cells producing cytokines, and intracellular transcription factors with …
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Exploring neuro-immune interactions in neurodegeneration: the role of B lymphocytes in Parkinson’s disease
… progression, focusing on the contribution of B lymphocytes. These cells play a number of roles including antibody production, maintenance of subcapsular sinus macrophages, antigen presentation and regulation of T cell activity. Methods: I phenotyped peripheral blood B lymphocytes in 3 clinical …
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The Role of Id Proteins in the Development and Function of T and B Lymphocytes
<p>E and Id proteins are members of the basic helix-loop-helix (bHLH) transcription regulator family. These proteins control a broad range of lymphocyte biology, from the development of multiple lineages to execution of their effector functions. With the development of new experiment models, novel …
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Establishing the Role of DC-SIGN and Glycoprotein H for KSHV Entry in B Lymphocytes
… viral entry process of KSHV in tonsil-derived B lymphocytes. This study will particularly explore the role of KSHV glycoprotein gH and cell surface receptor DC-SIGN.</p> <p>The first aim of this project will investigate whether the cell surface receptor, DC-SIGN, is required for viral entry of …
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Taming a Potent Mutator: Identification and Characterization of Novel Mechanisms of Regulating Antibody Diversification in B-Lymphocytes
… virtually infinite array of foreign pathogens. Blymphocytes, the mediators of humoral immunity, have developed extensive mechanisms of gene diversification collectively known as antibody diversification. Antibody diversification, a set of processes necessary for an organism to mount a specific …
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Characterization of a Novel Receptor CS1 in Human Lymphocytes; Studies in Natural Killer Cells and B-Lymphocytes
… was to investigate the roles of CS1 on human lymphocytes. The molecular and functional characterization of CS1 receptor in the natural killer (NK) cells and B lymphocytes was investigated. CS1 (CRACC, novel Ly9) is a novel member of the CD2 family receptor expressed on natural killer (NK), T …
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