Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"B lineage"”.
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The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics
<p>Anti-apoptotic MCL1 is one of the most frequently amplified genes in human cancers and its elevated expression confers resistance to many therapeutics including the BH3-mimetic agents ABT-199 and ABT-263. The anti-malarial, dihydroartemisinin (DHA) translationally represses MCL-1 and synergizes …
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Mechanism for Pre-B Cell Loss in Mutant Ali/Ali Rabbits
… checkpoint in B cell development in which B-lineage cells expressing functional μ-chains undergo selective expansion. My dissertation work used a rabbit model system to study how VH structure affects the early stages of B cell development in the bone marrow (BM). Developing B cells in mutant …
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Role of Notch Signaling and GATA-3 in Establishing T-lineage Commitment and Survival in Developing Thymocytes
… is required to commit progenitors to the T-lineage and acts in concert with many transcription factors such as GATA-3 to fully induce this fate choice while inhibiting the B-cell lineage. Although both Notch and GATA-3 are indispensible for thymocyte development, their precise roles in …
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Biogenesis of Membrane-Bound and Secreted Immunoglobulins
… molecules are so defined as members of the B lineage; the end-stage cell type of this lineage is the plasma cell. The acceptance, over the past thirty years, of myeloma proteins as normal products of plasma cells in clonal overgrowth (Kunkel, 1966) has provided both a homogeneous source for …
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ELUCIDATING REGULATORY NETWORKS PROMOTING B-CELL DEVELOPMENT
… of the transcriptional network orchestrating B-lineage specification and commitment. Based on the combined expression of surface markers and transgenic reporter genes, we have identified three hierarchically related and functionally distinct subpopulations within the common lymphoid progenitor …
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Towards a B-Lymphoid Model of E2A-PBX1-Mediated Leukemogenesis: Evaluating the Impact of Hematopoietic Cell of Origin on the Transformation Properties of a Leukemogenic Transcription Factor
… leukemia model. We initially determined that lineage-negative (lin-) hematopoietic progenitors expressing E2A-PBX1 expression fail to repopulate the B-lymphoid lineage when transplanted into irradiated recipient mice. Furthermore, E2A-PBX1 expressing, lin- fetal liver progenitors (FLPs) fail …
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Genetic variation among Zulu sheep sub-populations of South Africa assessed by microsatellites and mitochondrial DNA (mtDNA)
… showed two haplogroups (A and B). Haplogroup B lineage predominates among Zulu sheep with a frequency of 93%, while A lineage had a frequency of 7%. The analysis of mtDNA showed a high level of genetic diversity among Zulu sheep. The molecular information obtained in the present study will serve …
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Targeting An Ancient Retrovirus During Melanoma Using Adoptive T Cells Therapy
… CAR<sup>+</sup> T cells in patients with B-lineage malignancies. To generate T-cell therapy for melanoma we targeted a TAA derived from human endogenous retroviruses (HERV), whose genome stably integrated into humans millions of years ago. During oncogenesis, biologically active variants of …
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Advancing RNA Virus Discovery and Biology with Whole Genome Sequencing
… strain to be associated with the PUUV Latvian lineage.</p> <p>Early during the SARS-CoV-2 pandemic, I applied the knowledge gained in the hantavirus WGS efforts to sequencing of SARS-CoV-2 from nasopharyngeal swabs collected in April 2020. The genetic diversity of 45 SARS-CoV-2 isolates was …
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The Impact of Heat Stress on Immune Function
… immune imprints. While most early and B-lineage progenitors recovered one month after stress cessation, haematopoietic stem cell (HSC) pools remained as depleted as under chronic stress. Single-cell RNA sequencing revealed that acute heat stress first metabolically activated then …
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Clonal Studies of Human B Cells
… However, the characteristics of human fetal B-lineage cells are less understood. Recent studies of fetal and human umbilical cord B cells indicated that CD27, a well-established marker of human memory B cells, may also be expressed on human B1-like B cells. Indeed, CD27+ B cells are present in …
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Functional Drivers of Therapeutic Response in Diffuse Large B Cell Lymphoma
… that knocks out Rhoa in either the full B cell lineage or germinal center B (GCB) cells specifically. We observe a massive loss of B cells across the B lineage driven by Rhoa deletion. In the GCB restricted knockout, we find that GCB cell numbers are reduced, the dark zone to light zone …
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Studio del meccanismo di riparazione del DNA nelle leucemie in età pediatrica: alterazioni dei geni NBS1, Fancd2, Palb2 ed espressione dei geni BRCA1 e BRCA2.
Il successo del trattamento della leucemia linfoblastica acuta di linea B (LLA B) nei bambini è correlato a nuovi risultati biologici e a una migliore terapia di supporto. Le aberrazioni genomiche hanno un ruolo importante nello sviluppo della LLA e nella risposta al trattamento. Il trattamento …