Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 508 for “"B cells"”.
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Investigating pulmonary vascular B cells
… previously determined that pulmonary vascular B cells regulate neutrophils via CD18-mediated interactions, labelling them MHCII+AnnexinV+, and that in the absence of B cells, the lung will develop pathological fibrotic interstitial lung disease. In this body of work, we determined that pulmonary …
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Clonal Studies of Human B Cells
… and adaptive immunity. The diverse roles of B cells can be attributed to the various and distinct types of B cells as determined by their origin, developmental stage, antigen specificity, and function.</p><p>Evidence suggests that human innate-like B cells (i.e., marginal zone and/or B1-like B …
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IL-25 and B cells in atherosclerosis
… an association between high levels of CD19+CD40+ cells and a decreased risk of stroke while high levels of CD19+CD86+ B cells were associated with an increased risk. Another main focus was the investigation of the role of IL-25 in atherosclerosis. In order to tackle this, the cytokine was both …
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Methods to Study Antigen-Specific B cells
… of highly specific B and T lymphocytes. B cells achieve this through somatic diversification of the B cell receptor which results in an unimaginably large repertoire of cells that can recognise a vast array of antigens. Studying the antigen-specific B cell repertoire is important for our …
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MODELING, ANALYSIS, AND CONTROL OF SYK-MEDIATED SIGNALING EVENTS FOR B CELLS AND ASSOCIATED CELLULAR RESPONSE FOR B CELLS
… is a matter of understanding the immune cells involved, their individual responses, and chemicals responsible for intracellular and intercellular communication. The overall immune response is driven by individual actions of neutrophils, antigen-presenting cells, and lymphocytes (T cells …
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Golgi Specificity and Development of Autoreactive B Cells
… bound DNA very well. How did these anti-DNA B cells escape central tolerance? In our effort to answer this puzzle, we discovered that receptors with the Vk38c light chain may have specificity to a Golgi antigen in addition to DNA. This suggested that such anti-DNA receptors may bind to an …
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Engineering B Cells For Use In Immunotherapy and Cancer
<p>B cells can be divided into effector and regulatory immune cells. While effector B cells are key drivers of humoral immunity due to their ability to generate antibodies specific to pathogens, regulatory B cells (Bregs) have recently been shown to control inflammatory responses in multiple …
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Long-read transcriptome profiling of germinal centre B cells
… spliced genes are specific to immune cells, yet the regulation and function of AS during B cell activation remain largely unknown. The activation of naive B cells and the subsequent germinal centre (GC) reaction drive the cascade of reactions resulting in short- and long-term antibody …
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The Role of Transitional B cells in Kidney Transplantation Tolerance
… have revealed an expansion of peripheral blood B cells and over- expression of B cell-related genes. In humans, Memory, Naïve and Transitional B cells are the main B cell subsets found in circulation, and it is has been shown that the Transitional subset, defined by its regulatory properties, is …
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Understanding the Effects of Ageing on B cells Response to Vaccination
… to vaccination during ageing. I show that B cells from older people do not have defects in their proliferation and differentiation into antibody-secreting cells *in vitro* compared to those from younger donors. Adoptive transfer of B cells from aged SW<sub>HEL</sub> mice into young adult …
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Virus-Host Interactions during Epstein-Barr virus Latent Infection of B cells
… and after establishment of latency in B cells to study host mRNA changes associated with latent infection. Here we identified transcription and splicing factors to be uniquely regulated by EBV at the level of mRNA isoform. Finally we identified two host factors that regulate the switch …
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A functional role for transfer RNA-derived microRNAs in human B cells
… in recent decades have revealed that the cells of most eukaryotic organisms express a diverse repertoire of small RNAs. Genetic and biochemical investigation of these molecules has demonstrated that many small RNAs, most notably the microRNA subclass, possess the capacity to influence the …
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Targeting the CD19/CD21 complex on B cells in the mixed lymphocyte reaction
B cells exert antigen presenting functions at the crossroad between immune activation and tolerance induction, a fate notably governed by the B Cell Receptor (BCR) response regulator CD19/CD21 complex. This duality in B cells raises a particular interest in the case of acute graft-versus-host …
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Molecular, functional and developmental analysis of B cells at discrete stages of development
… is limited. An example of this is transitional B cells. Although transitional B cells are known to exist in humans, detailed characterisation of these cells has not been performed. Human transitional B cells can be identified as CD24++CD38++CD10+ cells and attempts have been made to segregate them …
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Phenotype and function of B cells in children infected with human immunodeficiency vius
… Defects in phenotype and function of B cells have been well characterized in HIV -infected adults. However, only a few studies have investigated the effect of HIV on the B-cell compartment in children, and such studies have been less detailed than in adults. As a result, much remains to …
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The VH repertoire and clonal diversification of B cells in myositis and vasculitis
… but it is becoming increasingly evident that B cells, and their cognate antibodies, play a significant and contributory role in disease pathogenesis. Therefore establishing the occurrence of highly-specific B cell antigen-driven adaptive immune responses within autoimmune disorders would provide …
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Nanoscale antigen organization regulates binding to specific B-cells and B-cell activation
… addition, isolation of antigen-specific memory B cells that would elucidate the long-term efficacy of vaccines beyond using antibody titers as surrogates has been challenging due to the lack of specific and sensitive detection reagent. We sought to improve the binding and activation of B cells by …
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The exploitation of neuronal survival factors in Burkitt’s lymphoma and germinal centre B cells
… expression of neurotrophin components in immune cells, the present study investigates neurotrophin component expression within Burkitt’s Lymphoma B cells. Different latency stages within Burkitt’s Lymphoma B cells are observed due to the expression of resident EBV latency genes. These B cells are …
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Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells
… nematode infection that affects rodents. B-cells have been shown to play an important role in immunity to many different infections by antibody production and T-cell activation. But B-cell function in the protective TH2 response against N. brasiliensis infection is an area of immunity that …
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Meningeal B cells in central nervous system autoimmunity: Their phenotype and susceptibility to therapeutic depletion
… (MS), yet to date little is known about how B cells promote disease pathogenesis. B cells can be found invading the meninges around the brain and spinal cord in MS, where they cluster in association with T cells. These meningeal B cells clusters are often adjacent to demyelinating lesions …
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