NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 5 of 5 for “"B cell transformation"”.

  1. Of Mice and Men: Studying Innate and Adaptive Immunity Against the Epstein-Barr Virus

    Strowig, Till

    … This transforming property can be observed as B cell transformation in vitro and lymphomas as well as epithelial cancers in vivo, but most immunocompetent individuals control EBV infection successfully without the occurrence of disease. Cells of the innate immune system act in synergy to provide …

    rockefeller Repository record

  2. Harnessing synergy between BCL6 and PI3Kδ to generate a new mouse model for lymphoma

    Cugliandolo, Fiorella MariaUniversity of Cambridge2020

    … 3-kinase (PI3K) pathway is critical for immune cell development and function. Patients with a gain of function mutation in PI3Kδ, called Activated PI3Kδ syndrome (APDS) commonly develop autoimmunity, lymphoproliferation, and lymphoma. PIK3CD is also among the most commonly mutated genes in …

    cambridge Repository record

  3. Detecting Changes in Alternative mRNA Processing From Microarray Expression Data

    Robinson, Timothy J.2010

    … changes in global mRNA processing during B cell transformation and show that the conventional U133 platform is able to detect 3' located changes in mRNA processing five times more frequently than the Human Exon array.</p>

    duke Repository record

  4. Control of the EBV growth transformation programme: the importance of the Bamhi W repeats

    Kao, Kuan-YuUniversity of Birmingham2011

    … latent genes whose constitutive expression in B cells leads to cell growth transformation. The initiation of this B-cell growth transformation programme depends on the activation of a viral promoter, Wp, present in each tandemly arrayed BamHI W repeat of the EBV genome. In order to examine the …

    birmingham Repository record

  5. Elucidating oncogenic mechanisms in human B cell malignancies

    Caeser, RebeccaUniversity of Cambridge2018

    … Leukaemia (ALL) and Diffuse Large B Cell Lymphoma (DLBCL). Firstly, Pre-B ALL represents the most common paediatric malignancy and despite increasingly improved outcomes for patients, ~ 20% of all patients diagnosed with ALL relapse. Activating mutations in the RAS pathway are common …

    cambridge Repository record