Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"B cell subsets"”.
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Changes in peripheral B cell subsets under immunosuppressive therapy
… may progress to chronic autoimmune diseases. B cells play an important role in the pathogenesis of autoimmune diseases and influence autoimmunity through multiple pathways. With the availability of informative B cell surface markers it is now possible to identify within the circulating B cell …
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B cell memory in STAT3 Hyper-IgE Syndrome: Cytokine integration, IgE regulation, and the architecture of human memory B cell subsets
… life-threatening allergic disease. However, the cellular reservoir of IgE memory in humans is incompletely characterised and prior studies have been unable to reproducibly detect human IgE+ memory B cells (MBCs). Individuals with Inborn Errors of Immunity (IEI) shed light on the molecular and …
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CD21 and CD24 Co-expression: A Translational Model between Mouse and Human
… Erythematosus and Rheumatoid Arthritis are B cell-mediated autoimmune diseases that afflict millions of people worldwide. B cell-targeted therapies for these diseases result in variable clinical outcomes. Thus, a need exists to better understand the dynamics of human B cell production and …
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Lymphocyte subset variability between human lymphoid tissues
… lymphocytes to date have primarily investigated cells from the blood, and lymphoid tissues remain poorly studied. This thesis explores the hypothesis that there is local variation of B cell subsets between the tissues that are micro-anatomically different and receive antigenic stimulation via …
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The Role of Transitional B cells in Kidney Transplantation Tolerance
… have revealed an expansion of peripheral blood B cells and over- expression of B cell-related genes. In humans, Memory, Naïve and Transitional B cells are the main B cell subsets found in circulation, and it is has been shown that the Transitional subset, defined by its regulatory properties, is …
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IL-25 and B cells in atherosclerosis
… In the present work we report that different B cell subsets could potentially be used as biomarkers for the prediction of future stroke events. Specifically, our findings demonstrate an association between high levels of CD19+CD40+ cells and a decreased risk of stroke while high levels of …
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Regulation of Protective B cell Anti-Tumor Responses
The role of B cells in tumor progression is complex and often overlooked. Specifically, little is known about the extent to which the specialized populations of innate-like B-1a and B-1b cells participate in and contribute to the anti-tumor immune response. The totality of work presented in this …
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Activation of T regulatory cells in Type II Immune Responses
… infection or malignancy. We examined changes in subsets of CD4+ T cells, CD4+CD25+CD127lo T regulatory cells (Treg), and B cells of patients on dialysis (ESKD) and renal graft recipients of varying lengths, and compared them to healthy volunteers. Demonstrating the heterogeneity of Treg, Miyara …
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PHARMACOLOGICAL MODULATION OF THE ADAPTIVE IMMUNE SYSTEM IN ISCHAEMIC HEART DISEASE
… myocardial infarction (MI). Regulatory T (Treg) cells are a subset of the adaptive immune system involved in immune tolerance. Animal models show that increasing Treg cell numbers in atherosclerosis can limit disease progression. Several small clinical studies have used low dose interleukin-2 …
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Early Growth Response Protein 2 (EGR2) regulation of B cell differentiation in lupus-prone mice
… treatment. It involves abnormal activation of B cells, which produce pathogenic autoantibodies that contribute to inflammation and tissue damage in multiple organs. Therapeutic depletion of B cells in human lupus patients had mixed success due to the complex heterogeneity of B cell subsets, …
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B cell therapy in ANCA-associated vasculitis
… includes neutrophil activation by B cell-derived ANCAs, activation of the alternative complement pathway, and dysregulated T cell responses that result in a necrotizing vasculitis of small blood vessels. The central role of B cells is highlighted by the presence of activated B cells …
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PKB/Akt : a critical regulator of lymphocyte, development and function
… kinase, is highly involved in the regulation of cellular proliferation and survival. To characterize PKB’s function in lymphocyte development and activation, transgenic (tg) mice that express a membrane targeted constitutively active form of PKBa (myr PKB) in T and B cells were analysed. …