Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"B cell signaling"”.
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Investigations on the role of SLP-65 and other B cell signaling proteins in human leukemia
… an adaptor protein preferentially expressed in B cells with a central role in BCR and pre-BCR mediated signal transduction. By providing multiple binding sites for other cellular effector molecules it assembles various proteins into one signaling complex. Therefore SLP-65 is involved in the …
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B Cell Signaling and Bioinformatics: Revealing Components of the MHC Class II Antigen Processing and Presentation Pathway
Stimulation of mature B lymphocytes by extracellular ligands induces phenotypic changes through complex signal transduction pathways. Gene expression is altered as a result of these changes and re-programs the cell to undergo differentiation, activation, effecter function, anergy, and/or apoptosis. …
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A TOLL-LIKE RECEPTOR-INDUCIBLE AND B CELL-SPECIFIC ENHANCER REGULATES MURINE GAMMAHERPESVIRUS 68 LATENCY AND REACTIVATION
… lymphadenopathies, carcinomas, and lymphomas. B cells are the main latent reservoir of gammaherpesviruses. A central question is how B cell signaling regulates viral gene expression during establishment and reactivation from latency. The MHV68 M2 gene, a proposed functional analog of the EBV …
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Defining the role of toll-like receptor 10 in immune signaling
… TLR family. Given the established role of TLR signaling in both the innate and adaptive arms of immune defense, defining the function of TLR10 in the immune response would fill a significant knowledge gap regarding the question of why the gene has been propagated through evolutionary history. …
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The Role of Hspa9 in Mouse Hematopoiesis and IL-7 Receptor Signaling
… syndrome (MDS), a clonal hematopoietic stem cell disorder. Cytogenetic abnormalities occur in ~50% of MDS patients and an interstitial deletion or loss of chromosome 5 containing HSPA9 is the most common, occurring in up to 25% of patients. In order to understand the role of HSPA9 in …
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STAT3, NF-κB, and Estrogen Receptor Beta: The Balance of Inflammation in K-ras Mutant Lung Adenocarcinoma
… therapies that target this inflammatory signaling network in the TIME. This network is underpinned by interaction and coordination of two inflammatory pathways: signal transducer and activator of transcription 3 (STAT3) and nuclear factor kappa B (NF-κB). The balance of these …
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The Dual Role of OCA-B in B Cell Development and Signaling
<p>OCA-B (Oct coactivator from B cells) is a B-cell specific coactivator of transcription that acts in conjunction with the ubiquitously expressed activator, OCT-1 or the B cell-restricted OCT-2. OCT-1 or OCT-2 can bind an upstream octamer element with the consensus sequence 5'-ATGCAAAT-3' in …
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REDOX REGULATION OF B CELL ACTIVATION AND THE ANTI-VIRAL HUMORAL IMMUNE RESPONSE
… studies suggest that ROI facilitate normal cellular physiology by acting as secondary messengers generated following receptor ligation. Our understanding of the role of these molecules during the humoral immune response, the oxidation events that modulate B cell signaling, and their …
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MODELING, ANALYSIS, AND CONTROL OF SYK-MEDIATED SIGNALING EVENTS FOR B CELLS AND ASSOCIATED CELLULAR RESPONSE FOR B CELLS
… is a matter of understanding the immune cells involved, their individual responses, and chemicals responsible for intracellular and intercellular communication. The overall immune response is driven by individual actions of neutrophils, antigen-presenting cells, and lymphocytes (T cells …
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Verwendung von Gene-Targeting-Techniken zur Etablierung neuer Mauslinien mit Mutationen in B-Zell-Signalwegen
Das Hauptthema der hier vorliegenden Arbeit befaßt sich mit dem B-Zell spezifischen Oberflächenprotein CD22, einem Mitglied der Siglec (Sialinsäure bindende Igähnliche Lektine) Proteinfamilie. Dieses Transmembranprotein besitzt sieben extrazelluläre Immunoglobulin-ähnliche Domänen und kann über die …