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Showing 1 to 4 of 4 for “"B cell selection"”.
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Hapten Binding by Lymphocyte Surface Immunoglobulin and the Subsequent Implications for Affinity Maturation
… to another animal model (BALB/cV). Third, in a B cell plasmacytoma (MOPC-315) which had experienced isotype class switch to an (alpha) heavy chain, the immunoglobulin active site was identical between the cell's smIg and secreted immunoglobulin. Protein specificity and affinity for nitrophenyl …
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Signals for B cell activation in antibody response
… are the sites where V-gene hypermutation and B cell selection are taking place. Testing specificity and affinity of GC B cell receptor by interaction with antigen on follicular dendritic cells (FDCs) may be an important selection process to select high affinity B cell clone. As antigen on FDC is …
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Selection Dynamics in the Germinal Center During Antibody Affinity Maturation
… upon infection or immunization. High affinity B cells are selectively expanded in the GC by iterative rounds of migration between a zone of hypermutation and proliferation (the dark zone, or DZ) and a zone of selection (the light zone, or LZ). The mechanism whereby somatic antibody mutants are …
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Recording Cellular Interactions in Germinal Centers and Beyond
<p>In multicellular organisms, each cell has a distinct identity characterized by unique transcriptional and chromatin accessibility profiles. However, to truly understand the organization and function of such systems, it is not enough to merely characterize individual components; we must also …