Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"B cell response."”.
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HIV Specific B Cell Response in Patients With Broadly Neutralizing Serum Activity
… the broadly neutralizing memory antibody responses to HIV we cloned 1078 antibodies from HIV envelope binding memory B cells from eight HIV infected patients with broadly neutralizing antibodies. We found that in these patients, the B cell memory response to gp140 is composed of up to 50 …
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A Characterisation and Understanding of the Germinal Centre B Cell Response to Atherosclerosis in Mice using Lineage Tracing
… neo-epitopes that drive inflammatory immune responses underlying the pathogenesis of atherosclerosis. The germinal centre is found within secondary lymphoid organs and is responsible for the production of high affinity antibody-producing plasma cells and long-lived memory B cells against …
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Early divergent B cell differentiation during antibody responses
The early B cell response to antigen is analyzed, probing the mechanisms of divergent differentiation into plasmablasts or germinal centre (GC) B cells. Heterozygous QMxB6 mice, in which 5% of B cells are specific for the hapten 4-hydroxy-3-nitrophenol (NP), were immunized with NP-Ficoll. Varying …
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Expression and Immunological Characterization of Herv-K Transmembrane Envelope Protein In Human Breast Cancer
… cancer and the stimulation of SU-specific immune responses in patients with breast cancer, our research here confirmed and extended the data by investigating the expression of HERV-K TM envelope domain and the induction of specific immune responses against TM in breast cancer patients. We found …
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An investigation into the Humoral Response in Cutaneous Melanoma
… from the malignant proliferation of melanocyte cells. There are 4 subtypes, of which cutaneous melanoma (CM), is the most prevalent (Rabbie et al., 2019). The T cell immune response in melanoma has been well defined, however, the B cell response is much less understood (Rodgers et al., 2022). …
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The role of cell autonomous complement in B cell function and regulation
B cells are a cornerstone of the adaptive immune response as they not only differentiate into antibody-producing plasma cells, mediating protection from pathogens, but also have several antibody-independent, immune-regulatory functions. Even with these essential roles, some aspects of their …
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A B-cell or a key player?: The role of the humoral immune response in melanoma, highlighting the importance of method development
Investigations of the humoral immune response to melanoma have revealed that B-cells and antibodies can play both pro and anti-tumourigenic functions. B-cells can infiltrate melanomas and become organised into a tertiary lymphoid structure; their presence have been associated with better …
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Apoptosis of Peripheral Blood Leukocytes in Systemic Lupus Erythematosus: Studies on Serum Induction and Complement-Dependent Clearance Mechanisms
… of type I interferons, a hyperactive B-cell response, presence of autoantibodies against modified nuclear components, increased complement consumption, increased apoptosis and decreased clearance of apoptotic cells are seen. The purpose of this thesis was to investigate some of these …
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Plasmacytoid Dendritic Cell-Mediated Humoral Autoimmunity
… is characterized by the breakdown of B cell immune tolerance to self-antigens and consequent production of pathogenic autoantibodies. Plasmacytoid dendritic cells (pDCs), a potent type I interferon (IFN-I) producer, have been linked to the pathogenesis of systemic lupus erythematosus …
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B cell memory in STAT3 Hyper-IgE Syndrome: Cytokine integration, IgE regulation, and the architecture of human memory B cell subsets
Deleterious allergen-specific IgE responses cause lifelong and life-threatening allergic disease. However, the cellular reservoir of IgE memory in humans is incompletely characterised and prior studies have been unable to reproducibly detect human IgE+ memory B cells (MBCs). Individuals with Inborn …
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Nanoscale antigen organization regulates binding to specific B-cells and B-cell activation
… addition, isolation of antigen-specific memory B cells that would elucidate the long-term efficacy of vaccines beyond using antibody titers as surrogates has been challenging due to the lack of specific and sensitive detection reagent. We sought to improve the binding and activation of B cells by …
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Determination of functionally distinct subsets of human tonsillar and blood T follicular helper (Tfh) cells.
T follicular helper (Tfh) cells represent a CD4+ T cell subset specialized for B-cell help. While our knowledge on the biology of Tfh cells has dramatically increased during the past decade, a vast majority of observations were made in mouse models. Our knowledge on the biology of human Tfh cells …
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Determination of functionally distinct subsets of human tonsillar and blood T follicular helper (Tfh) cells.
T follicular helper (Tfh) cells represent a CD4+ T cell subset specialized for B-cell help. While our knowledge on the biology of Tfh cells has dramatically increased during the past decade, a vast majority of observations were made in mouse models. Our knowledge on the biology of human Tfh cells …
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Development of polymeric nanoparticle vaccines for immunostimulation
… and 2) providing a tunable surface for loading B cell antigen epitopes in a specific conformation to drive epitope-specific antibody response. In recent decades, TLR mechanisms have been elucidated and novel agonists have been developed, yet our generation still has not seen paramount progress in …
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SARS-CoV-2 Variants and Vaccines
… a pandemic and for countries to enforce national responses, such as widespread lockdowns and preventative measures including mask wearing and social distancing. Several vaccines were rapidly developed. These included BioNTech Pfizer’s BNT162b2 mRNA-based vaccine, Moderna’s mRNA-1273 mRNA-based …
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The Role of Histone Deacetylase 6 Inhibition on Systemic Lupus Erythematosus
… important molecular pathways in diverse immune cells. Both innate and adaptive immune cells contribute to pathogenesis of lupus. Among those cells, B cells play a central role in pathogenesis of lupus nephritis in an anti-body dependent manner through differentiation into plasma cells (PCs). As …
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Studying the B and plasma cell responses to the immune checkpoint blockade treatment of cancer
… their effects on anti-tumour B and plasma cell responses, which are now regarded as important components of the adaptive immune response to cancer. Additionally, the utility of ICB therapies is limited by the immune-related adverse events (IrAEs) they induce – toxic autoimmune conditions …