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Showing 1 to 15 of 15 for “"B cell repertoire"”.

  1. Idiotope-Specific Regulation Of The Murine Anti-Phosphorylcholine B Cell Repertoire.

    Pollok, Brian Andrew

    uab Repository record

  2. MODULATION OF THE B-CELL REPERTOIRE IN RHEUMATOID ARTHRITIS BY TRANSIENT B-CELL DEPLETION

    Rouzière, Anne-SophieUniversität Würzburg

    Although the role of B-cells in autoimmunity is not completely understood, their importance in the pathogenesis of autoimmune diseases has been more appreciated in the past few years. It is now well known that they have roles in addition to (auto) antibody production and are involved by different …

    wurz-thes Repository record

  3. Functional Involvement Of Auto-Anti-Idiotypic Antibodies In The Programmed Development Of The B Cell Repertoire In Mice (Ontogeny).

    Vakil, Meenal

    uab Repository record

  4. Humanized Mouse with a Diverse Polyclonal B Cell Repertoire as a Model for Neutralizing Antibody Responses against EBV and HIV

    Chhan, Crystal Belle2026

    … difficult to model human neutralizing B cell responses to these two viruses using small animals. I leveraged a transgenic mouse model that encodes a genetically human antibody repertoire to generate neutralizing monoclonal antibodies (mAbs) against the EBV gp350 and gp42 glycoproteins, …

    washington Repository record

  5. On Immunological Imprinting

    Johnston, Timothy, Stuart2026

    … to an antigen establishes a population of memory cells capable of responding to future encounters to the same antigen with increased speed and magnitude. For rapidly mutating respiratory pathogens such as influenza viruses and SARS-CoV-2, subsequent encounters are not to the same antigen, but …

    penn Repository record

  6. The role of idiotype-specific immunity in antigen receptor diversity

    Millar, David GeorgeUniversity of Birmingham2010

    … to determine whether editing of the lymphocyte repertoire is present in an HLA-dependant manner. Data presented demonstrates a decrease frequency of CDR3-derived HLA-A2 binding peptides in HLA-A2+ donors (0.03% (SYFPEITHI) and 0.35% (BIMAS)) compared with HLA-A2- donors (0.24% (SYFPEITHI, …

    birmingham Repository record

  7. The Role of Foxo Transcription Factors in B Cell Development and Activation

    Hinman, Rochelle Marie2011

    … system depends on a diverse, self tolerant B cell repertoire. Mature B cells distributed throughout secondary lymphoid organs respond to antigenic stimuli by dividing and differentiating into plasma cells and other effector cell types. Signaling from the B cell receptor (BCR) plays a critical …

    utswmed Repository record

  8. Development of microanalysis tools for characterization of the humoral response to infections diseases

    Ogunniyi, Adebola OMassachusetts Institute of Technology2013

    … produced by a subset of lymphocytes (B cells) in the immune system for protection against pathogenic species. These homodimers of heterodimers form highly specific interactions with their cognate antigens and hence have become very important for the development of prophylactic or …

    mit Repository record

  9. Exploration of B cell diversity in the human lung

    Aihara, Fumiaki2022

    … organisms and non-infectious commensals. B cells in the lungs are a key member of adaptive immunity by producing antigen specific antibodies as well as immune regulatory roles by secreting various cytokines. In this work, we utilized lung and blood samples paired by donor to test the theory …

    bu Repository record

  10. Humoral immune response to melanoma: discovery and evaluation of anti-melanoma antibodies

    Gilbert, AmyKing's College London2013

    … nature. While numerous studies have examined T cell-mediated immune responses to melanoma and their therapeutic potential, there has been less focus on B cell-mediated immune responses and the tumor-reactive antibodies they produce. The aim of this work was three-fold: (1) to develop a …

    kings Repository record

  11. Pre-BCR signaling amplifies antibody diversity by activating secondary immunoglobulin heavy chain gene rearrangement

    Khadour, AhmadUniversität Ulm

    ulm-diss Repository record

  12. STUDIES OF B CELL DEVELOPMENT AND V(D)J RECOMBINATION

    Chovanec, PeterUniversity of Cambridge2019

    … to produce antibodies is restricted to the B cell lineage and is tightly regulated, starting with the temporal separation of the recombination process, in which DH-JH precedes VH-DHJH recombination. Successful recombination of both heavy and light chain loci results in the expression of an …

    cambridge Repository record

  13. Methods to Study Antigen-Specific B cells

    Fischer, KatrinUniversity of Cambridge2021

    … of highly specific B and T lymphocytes. B cells achieve this through somatic diversification of the B cell receptor which results in an unimaginably large repertoire of cells that can recognise a vast array of antigens. Studying the antigen-specific B cell repertoire is important for our …

    cambridge Repository record

  14. The Ontogeny of Vaccine-Induced HIV-1 Glycan-Reactive Antibodies

    Meyerhoff, Robert Ryan2017

    … Due to the counter selection of B cells bearing antibodies with these characteristics by the host immune system, bnAb precursor B cells are rare in the B cell repertoire and would likely be difficult to engage through vaccination. As such, vaccinations using HIV-1 Env have induced …

    duke Repository record

  15. Clonal Studies of Human B Cells

    Su, Kuei-Ying2015

    … and adaptive immunity. The diverse roles of B cells can be attributed to the various and distinct types of B cells as determined by their origin, developmental stage, antigen specificity, and function.</p><p>Evidence suggests that human innate-like B cells (i.e., marginal zone and/or B1-like B …

    duke Repository record