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Showing 1 to 9 of 9 for “"B cell receptors"”.
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Golgi Specificity and Development of Autoreactive B Cells
<p>B cell receptors with certain heavy/light chain pairs predominate in the periphery of anti-DNA heavy chain transgenic mice while certain other B cell receptors are absent. We wanted to know why. To answer this, we re-constructed B cell receptors represented in the anti-DNA transgenic mice by …
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Recording Cellular Interactions in Germinal Centers and Beyond
<p>In multicellular organisms, each cell has a distinct identity characterized by unique transcriptional and chromatin accessibility profiles. However, to truly understand the organization and function of such systems, it is not enough to merely characterize individual components; we must also …
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Transcription, Editing, and Switching of Antibody Genes
<p>B lymphocytes are the antibody producing cells of the immune system. During B cell lymphopoiesis in the bone marrow, immunoglobulin molecules are assembled from V, D, and J gene segments through a process known as V(D)J recombination. Because of its stochastic nature, V(D)J recombination is …
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Mechanisms Underpinning Functional Resident Humoral Lung Immunity
… against autoimmunity and infectious disease. B cells undergo selection in secondary lymphoid tissue germinal centres which can improve the way their B cell receptors bind antigen and generate antibodies that provide protection against infections. Due to their de novo formation and less stringent …
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Single Molecule Localisation with Fourier Light Field Microscopy
… first applied to capture the organisation of B-cell receptors on the surface of a primary mouse B-cell over a continuous depth of 8 μm. This exceptional depth of field demonstrates that this tool can achieve faster 3D SMLM. The second application employed the technique’s high-density capability …
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Array based genetic profiling of chronic lymphocytic leukemia
… versus IGHV4-34 (good-prognostic) B-cell receptors. IGHV3-21 subset #2 (n=29) showed a high frequency of samples carrying genomic aberrations, and a particularly high prevalence of del(13q) and del(11q), which may correspond to the adverse survival reported for these patients. In …
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Presentation Of Citrullinated Peptides Derived From Unmodified Protein By Antigen Presenting Cells.
… from unmodified protein by antigen presenting cells. By Jamie Michelle Rimer Doctor of Philosophy in Biology and Biomedical Sciences: Immunology) Washington University in St. Louis 2010 Professor Emil R. Unanue, Chair Autoimmune responses to citrullinated proteins have been associated with …
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Adaptive Immune Responses to Vaccination Against SARS-CoV-2 in Individuals with Immune Dysregulation
… vaccination against SARS-CoV-2 were assessed. Cellular immune responses, driven by cytotoxic CD8+ T cells, appeared to be robust and well maintained across disease states. Impairment of the humoral, antibody and memory B cell, responses to vaccination was seen in those with elevated levels of …
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Interrogation and Manipulation of the IGG FC Glycan
… (Fc) domain, which interfaces with cells of the immune system. Often considered a constant region, the immunoglobulin G (IgG) Fc protein backbone and conserved N-linked glycan combine to introduce structural diversity in IgG molecules that in turn, triggers divergent humoral …