Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"B cell receptor signaling"”.
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The proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia
… and America. It is a malignancy of naive B-cells. The clinical course of patients with CLL is heterogeneous; some patients survive for years without treatment, others die of a chemotherapy resistant disease within two years of presentation. Genomic studies have found little variation in …
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Correlation Matrix Analysis Identifies Gene Signatures of Immune Cell Subsets and Their Interactions In Follicular Lymphoma
… ill-defined interactions between benign immune cell subsets and neoplastic B cells within follicular lymphoma (FL). Using the novel technique of correlation matrix analysis (CMA) of publicly available FL whole-tumor gene expression profiling (GEP) data, we have identified signatures of immune …
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Drug design strategies for modulating immune activity for the treatment of autoimmune diseases and cancer
… the body from foreign pathogens and damaged cells. Self-tolerance mechanisms exist to prevent the immune system from attacking normal cells. However, malfunctions in the self-tolerance mechanisms can result in the inability of the immune system of distinguishing self and non-self, cause …
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The Dual Role of OCA-B in B Cell Development and Signaling
<p>OCA-B (Oct coactivator from B cells) is a B-cell specific coactivator of transcription that acts in conjunction with the ubiquitously expressed activator, OCT-1 or the B cell-restricted OCT-2. OCT-1 or OCT-2 can bind an upstream octamer element with the consensus sequence 5'-ATGCAAAT-3' in …
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A computational approach to understanding maternal influences on the development of ruminant neonates
… of maternal immunoglobulins (IgGs) and immune cells. This vulnerability is further exacerbated by overlapping early-life health challenges, including metabolic, microbial, mucosal, and mental stress. Additionally, ruminant newborns possess limited energy and nutrient reserves within their …