Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"B cell maturation"”.
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CATALYTIC-INDEPENDENT FUNCTIONS OF KDM6A IN B CELL MATURATION AND IMMUNE REGULATION
… transcriptional activation of genes that control cell differentiation during embryonic development and postnatal life. It is recurrently mutated in several solid and hematological cancers and is responsible for Kabuki syndrome. While Kdm6a has been extensively studied in early hematopoiesis, …
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Η προκλινική και κλινική ανάπτυξη του Belantamab Mafodotin για τη θεραπεία του Πολλαπλού Μυελώματος/The preclinical and clinical development of Belantamab Mafodotin for the treatment of Multiple Myeloma
… αντισώματος που στοχεύει το αντιγόνο BCMA (B-cell maturation antigen), το οποίο εκφράζεται επιλεκτικά στην επιφάνεια των κακοήθων πλασματοκυττάρων, προσφέροντας αυξημένη αντικαρκινική δράση με περιορισμένη επίδραση στους υγιείς ιστούς. Η ανάλυση των προκλινικών δεδομένων καταδεικνύει ισχυρή …
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Communication at the Cellular Level: Discovery and Application
Cell-cell communication is essential to the functioning of all multicellular organisms, and understanding these critical processes can help solve current biomedical problems. As a demonstration of the utility of this approach, existing knowledge of the interactions between B cells and T cells in …
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The characterization of the ABF-1 promoter
… factors consists of proteins involved in cellular proliferation and differentiation. The HLH structure plays a key role in protein-protein dimerization and with the DNA target sites, referred to as E boxes containing the consensus DNA sequence CANNTG. One class of mammalian class I bHLH …
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Characterization of human IgA-inducing protein
… progress in characterizing the role of dendritic cells (DCs) in the activation and modulation of B cells. DC-secreted chemokines can induce B cell trafficking to the lymph nodes. DC-produced survival factors such as BAFF and APRIL have been shown to be essential for B cell maturation, but have …
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Common messenger molecules and cell types demonstrating neuroendocrine-immune interactions in the chicken
… systems in birds, and to shed light on a cell type within the bursa of Fabricius that has historically been postulated as a potential neuroendocrine-immune link, the bursal secretory dendritic-like cells (BSDC). An immunocytochemical approach was used to identify neuroendocrine cell …
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Developmental Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Induced and Exacerbated Autoimmunity in Adulthood
… compartment, prenatal TCDD affected thymocyte cellularity, differentiation and maturation as well as central tolerance as indicated by high levels of autoreactive Vβ TCR T cells in the periphery. Prenatal TCDD also altered bone marrow B lymphopoiesis and B cell maturation and differentiation …
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The Interaction of Early Growth Response Gene 1 and Myocyte Enhancer Factor 2C in the Murine Brain Cortex
… and central nervous systems, for instance, B cell maturation upon B cell receptor activation, tendon repair upon mechano-stimulation, and long-term spatial memory formation. In mammalian brains, EGR1 controls the responses to environmental stimuli such as chronic stress and physical contact. …
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Molecular and functional analyses of human synovial B-lymphocytes in rheumatoid arthritis
B-cells of the rheumatoid synovial tissue are a constant part of and, in some histopathological subtypes, the dominant population of the inflammatory infiltrate, located in the region of tissue destruction. The pattern of B-cell distribution and the relationship to the corresponding …
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Generation and analysis of transgenetic mice expressing catalytically inactive recombination activating gene-1
… activating genes (RAG1 and RAG2) are lymphoid cell-specific endonucleases that initiate V(D)J recombination; the mechanism by which the exons that encode the variable portion of both B and T cell receptors are assembled somatically from several variable (V), joining (J) and sometimes diversity …
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Monogenetic Immune Dysregulation Syndromes and their Effect on the Plasma Cell Compartment
… diseases, these interactions are altered. Plasma cells (PC) and their B cell progenitors, that play a key role in maintaining humoral and cellular memory, are impaired within these patients. We characterised different features of plasma cells in immune dysregulated individuals via flow cytometry …
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Protein Kinase D1 in Myeloid Cells Promotes Disease Progression and Severity in S. rectivirgula Induced Hypersensitivity Pneumonitis
… to granuloma formation. Myeloid lineage immune cells play a critical role in the early and late stages of the disease, and this activity is mediated through toll-like receptors (TLRs) expressed by these cells. Protein kinase D1 (PKD1) has previously been identified as a critical signaling …
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Identifizierung, Charakterisierung und funktionelle Analyse der Bindungspartner von APRIL und TACI auf Monozyten und Dendritischen Zellen
… proliferation inducing ligand) und BAFF (engl.:B cell activating factor of the tumor necrosis factor (TNF) family) sind zwei eng verwandte Liganden innerhalb der TNF-Familie. Beide Liganden teilen sich zwei Rezeptoren, TACI (engl.: transmembrane activator and CAML interactor) und BCMA (engl.: B …
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B Lymphocyte Development in Galt
… tissues (GALT), where bone marrow (BM)-derived B cells undergo a proliferative expansion and somatically diversify the immunoglobulin genes. Unlike in other species, B lymphopoiesis in rabbit arrests a few months after birth, and it is unclear how the peripheral B cell compartment is maintained …