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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"B cell lymphomas"”.
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Translational regulation in aggressive B-cell lymphomas
… (GC) reaction is a dynamic process where B-cells undergo recombination and somatic hypermutation of immunoglobulin genes in response to antigen stimulation. This essential component of the adaptive immune system is associated with cycles of intensive proliferation and selection, which …
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The Role of Nucleolin In B-Cell Lymphomas and Fas-Mediated Apoptotic Signaling
… mediating homeostasis, elimination of defective cells and more recently implicated in cancer promotion. Many effective anti-cancer therapies depend on Fas-mediated apoptosis to eradicate tumor cells and ineffective Fas-apoptotic signaling is a basis for primary as well as acquired resistance to …
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Molecular Insights of Primary Thyroid B-cell Lymphomas by Somatic Genetic and Immunogenetic Profiling
Primary thyroid lymphomas are commonly derived from a background of Hashimoto’s thyroiditis and comprise largely of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (EMZL) and diffuse large B-cell lymphoma (DLBCL), followed by follicular lymphoma (FL). The Du group has …
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Molecular characterisation of Diffuse large B-cell lymphomas (DLBCL) diagnosed at Groote Schuur Hospital (GSH)
Background: Diffuse large B-cell lymphoma (DLBCL) is an aggressive high-grade neoplasm characterised by a diverse spectrum of clinical, morphological, immunophenotypic, and molecular features and response to therapy and survival. It is the most common lymphoma subtype diagnosed in South Africa. …
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The Loss Of Genomic Uracil Homeostasis And Aid-Dependent Accumulation Of Dna Damage In B Cell Lymphomas
… of uracils throughout the genome of activated B cells and the ability of UNG2 glycosylase to excise these uracils is examined here. This interplay was also studied in cancerous B cells, with different results emerging in transformed cells versus healthy cells. Genomic uracil levels are found to …
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The Extent and Nature Of Chromosomal Rearrangements in B Lymphocytes
… are frequently involved in producing leukemias, lymphomas and sarcomas. Mature B cell lymphomas are unique among tumors in that they frequently carry clonal recurrent translocations. This may be the result of Activation Induced Cytidine Deaminase (AID) expression, which introduces a heretofore …
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THE ROLE OF DNA SENSOR SIGNALLING PATHWAY IN LYMPHOMA
… defense to eliminate viruses in the body. Intracellular viral infections are detected primarily by immune recognition of viral nucleic acids. Many intracellular DNA sensors induce the expression of pro-inflammatory cytokines and type I interferons (IFN) through the activation of the …
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Revealing the role of Gα13 in germinal centre lymphomas
Diffuse large B cell lymphoma (DLBCL) and Burkitt lymphoma (BL) are aggressive B cell malignancies, arising from the transformation of germinal centre (GC) B cells. Although potentially curable with immuno-chemotherapy, 40% of DLBCL patient relapse and eventually succumb to their disease. In recent …
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Synthesis of cis- and trans-3-fluoroacrylate, and inhibition of BCL6 targeting a non-reactive cysteine
… therapeutics for treating diffuse large B-cell lymphomas (DLBCLs) and triple negative breast cancers that are BCL6-dependent. In future work, the compound will be tested to validate the design principle. The results will guide the development of more potent and specific therapeutic agents.
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Automated Analysis of Flow Cytometry Data for B-Cell Lymphoma
… of hematolymphoid malignancies including B-cell lymphomas, is an innovative technique that measures the fluorescence of suspended cells. Traditionally, the method of evaluating the research and clinical study of flow cytometry data is done by the process of manual gating along with a review …
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Identification of Epstein-Barr virus proteins that inhibit the DNA damage response
… mononucleosis and can also induce a variety of B cell lymphomas and carcinomas. To promote viral replication and cell survival, EBV is known to manipulate the cellular DNA damage response (DDR). To date there have only been a few studies on the interplay between EBV and the DDR and the functions …
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Contributions of viral and cellular gene products to the pathogenesis and prognosis of aggressive lymphomas
High grade aggressive lymphomas have high mortality. By their nature, more than 40% of patients die from these diseases even with the improved treatment strategies currently available for oncology patients. The characteristic feature is that they are functionally heterogeneous and therefore have …
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Role of AID and microRNA-155 in c-myc-IgH Translocations
… V-JH region) are found in a number of mature B cell lymphomas in humans and mice. The breakpoints are frequently adjacent to the recombination signal sequences (RSSs) targeted by recombinase activating genes 1 and 2 (RAG1/2) during antigen receptor assembly in pre- B cells, suggesting that these …
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The Role of Activation-Induced Cytidine Deaminase in Antibody Diversification and B Cell Malignancies
… (SHM) and class switch recombination (CSR) in B cells. SHM alters the affinity of an antibody for its corresponding antigen by introducing point mutations within the variable region of the immunoglobulin (Ig) gene heavy chain locus. CSR replaces the Ig μ constant region with one of the downstream …
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Nuclear Export Signal Recognition by CRM1 Carrying the Oncogenic E571K Mutation and Structure-Based NES Prediction
Nuclear-cytoplasmic trafficking is an essential cellular process in eukaryotes that maintains and regulates the spatial distribution of key cellular processes in the nucleus and the cytoplasm. CRM1 is the major nuclear export mediator, which facilitates nuclear export of hundreds of protein and RNA …
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Epigenetic repression of the NFATc1 transcription factor in human lymphomas
We examined the regulation of NFATc1 in different lymphomas and observed an inversed correlation between the methylation status and expression of NFATc1. Our data demonstrate that aberrant DNA methylation associated with chromatin remodeling within nfatc1 locus is a major mechanism for the …
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Chimeric ANTI-CD19 Monoclonal Antibodies for the Treatment of Precursor B Cell Acute Lymphoblastic Leukemia
Thousands of people are diagnosed with B cell malignancies every year, yet the only FDA-approved immunotherapies for them are based on anti-CD20 monoclonal antibodies (MAbs). However, CD20 is not expressed on precursor B cell acute lymphoblastic leukemia (pre-B ALL), and CD20 expression is often …
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C-Rel Is A Transcriptional Target of Mesoderm Inducer In Xenopus Like 1 (Mixl1)
… crisis, AML (Acute myelogenous leukemia), B cell lymphomas and pediatric ALL (Acute lymphocytic leukemia). (ii) Retroviral transduction of Mixl1 induces AML in murine models. Nonetheless, mechanisms underlying MIXL1 mediated proliferative, survival advantages are unknown.</p> <p>The goal of …
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