Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"B cell leukemia"”.
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PHF6 modulates the chromatin landscape in B-cell leukemia
… the Plant Homeodomain Finger Protein 6 (PHF6) in leukemia and define its role in regulating chromatin accessibility to lineage-specific transcription factors. We show that loss of Phf6 in B-cell leukemia results in systematic changes in gene expression via alteration of the chromatin landscape at …
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Comparative Studies of TSLP and IL-7 in Normal Early Human Neonatal and Adult B Cell Development
… the role of cytokines in promoting human B cell development is important for understanding B cell leukemia and for developing strategies to restore B cell production that is lost during some therapies. The purpose of this study was to investigate the roles of the IL-7R ligands, thymic …
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Investigations on the role of SLP-65 and other B cell signaling proteins in human leukemia
… an adaptor protein preferentially expressed in B cells with a central role in BCR and pre-BCR mediated signal transduction. By providing multiple binding sites for other cellular effector molecules it assembles various proteins into one signaling complex. Therefore SLP-65 is involved in the …
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Mechanisms of microenvironmental paracrine signaling in cancer chemoresistance
… the context of a tissue environment, with cancer cells surrounded by many non-malignant cells that contribute to tumor growth and resistance to therapy. Yet much remains unknown about the tumor microenvironment and its impact on therapeutic response. The specific cell types and microenvironment …
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Niche disturbances in Chronic Lymphocytic Leukaemia affect HSC residency and drug resistance
… lymphocytic leukaemia (CLL) is an indolent B cell malignancy infiltrating the lymphatic system and invariably the bone marrow (BM). Although treatment options for patients with advanced disease have significantly increased in the past years and improved life-expectancies, the disease remains …
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Effects of diet and loss of ovarian hormone production on adiposity, inflammation, cecal integrity, and gut microbial communities of rodent models
… due to ovariectomy, but the expression of B cell leukemia/lymphoma 2 (BCL2) was greater (p<0.05) in OVX mice than SHM mice, indicating greater apoptosis associated with loss of ovarian hormone production. Cecal permeability was not different among treatment groups. However, OVX mice had lower …
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Role of ETV5 Mutations in B Cell Acute Lymphoblastic Leukemia
B cell acute lymphoblastic leukemia (B-ALL) develops through the acquisition of driver mutations that impair cell differentiation and promote proliferation. In human B-ALL, mutations in E26 transformation-specific (ETS) transcription factors are commonly reported. Our laboratory studies a mouse …