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Showing 1 to 1 of 1 for “"B cell immunology"”.
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Atm-/-Ung-/- Mice Present Reduced Levels of Switched Immunoglobulin Isotypes IgG1 and IgG3
<p>B cells excise and recombine the immunoglobulin heavy chain gene locus during class switch recombination (CSR). CSR is mediated by activation induced cytidine deaminase (AID) and results in a new immunoglobulin isotype that B cells will secrete and present. AID produces mutations that convert …