Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"B cell epitope"”.
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B-Cell Epitope Prediction for Improved Antibody Docking
… docking models, we propose to first train a B-Cell epitope predictor and to subsequently use it to produce a diverse set of candidate binding sites. Our epitope predictor achieves state of the art performance, with an ROC-AUC score of 76. We then show that, by properly post-processing the …
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B CELL EPITOPE MAPPING OF RIVAX, A CANDIDATE RICIN VACCINE ANTIGEN
… mediated and hence generating a comprehensive B cell epitope map of ricin toxin would not only help in evaluating future ricin vaccine candidates in humans but also provides an immunological rationale for designing new vaccine candidates. Previous studies have shown that toxin neutralizing …
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A Novel Platform to Generate Synthetic Vaccine Candidates
… by undergoing rapid mutations in immunodominant epitopes [4-6]. In addition, although they usually express conserved epitopes that are important for inducing neutralizing antibodies, in many cases these are not immunodominant. Traditional techniques in vaccine development have not been able to …
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Studies on the synergistic protective activity of cancer antigens associated to engineered bacterial Outer Membrane Vesicles
… was tested by decorating them with cancer epitopes and by following their capacity to elicit protective immune responses, alone or in combination, using cancer mouse models. Furthermore, we tested whether cancer cell-derived exosomes (TEXs) and OMVs can form complexes and whether such …
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Communication at the Cellular Level: Discovery and Application
Cell-cell communication is essential to the functioning of all multicellular organisms, and understanding these critical processes can help solve current biomedical problems. As a demonstration of the utility of this approach, existing knowledge of the interactions between B cells and T cells in …
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Characterising variation in the gene for the Dichelobacter nodosus Type IV fimbrial protein: Development of a molecular typing system
… residues, that is thought to comprise the B-cell epitope. Such sequence variation may account for the ineffectiveness of vaccines which currently employ a majority of isolates of Australian origin. These findings indicate that further characterisation of Jim A gene heterogeneity is required …
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Development of Virus-like particles (VLPs) Based Vaccines Against Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) and Porcine Epidemic Diarrhea Virus (PEDV)
… delivery vehicle for either PRRSV or PEDV viral epitope antigens. Recombinantly produced HBcAg forms an icosahedral capsid virus-like particle (VLP) that has 240 repeats in a single assembled particle. By inserting different epitope antigens from these porcine pathogens into the particle, we can …
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Structural and electrostatic analysis of HLA B cell epitopes: Inferences on immunogenicity and prediction of humoral alloresponses
… to fully describe the intricate nature of the B cell epitope-BCR interaction that initiates a humoral response. This interaction requires, but is not limited to, structural and electrostatic potential complementarity. The aim of this thesis is to describe a fully structural description of HLA …
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Development and Characterization of recombinant immunotoxins for cervical carcinoma
… infection. Whereby the virus infects epithelial cells of the cervix and integrates its viral DNA into the host's genome. The viral DNA encodes oncogenes and initiates various pathways within the cells to undergo oncogenesis. During oncogenesis the cells protrude various surface receptors to …
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Polysequence Nanomaterials for Immunomodulation
… However, the efficacy and applicability of such epitope-based vaccines are currently limited by difficulties in predicting immunogenic epitopes in outbred populations and a reliance on carrier proteins and adjuvants that can cause pain and swelling. Current vaccine platforms are further limited …
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Use of peptide microarrays for mapping viral b cell epitopes
… und HIV Chips wurden zu Analyse der Bindungs-Epitope von monoklonalen Antikörpern, Serumproben von HBV-Immunisierten oder infizierten Personen sowie von HIV/SIV immunisierten Rhesusaffen verwendet. Die beiden Chips mit den überlappenden Peptiden erlaubten lineare B-Zell- Epitope mit hohe …