Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"B cell acute lymphoblastic leukemia"”.
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Role of ETV5 Mutations in B Cell Acute Lymphoblastic Leukemia
B cell acute lymphoblastic leukemia (B-ALL) develops through the acquisition of driver mutations that impair cell differentiation and promote proliferation. In human B-ALL, mutations in E26 transformation-specific (ETS) transcription factors are commonly reported. Our laboratory studies a mouse …
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BiTEs and CAR-Ts : immunotherapy in childhood B-cell acute lymphoblastic leukemia
B-cell acute lymphoblastic leukemia is the most common pediatric cancer, responsible for the most cancer-related deaths in children. Advances in chemotherapy over the past half-century have steadily increased the remission and survival of children with B-cell acute lymphoblastic leukemia to nearly …
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TSLP-induced Mechanisms and Potential Therapies for CRLF2 B-cell Acute Lymphoblastic Leukemia
<p>Childhood CRLF2 B-cell Acute Lymphoblastic Leukemia (CRLF2 B-ALL) is a high-risk form of leukemia that is associated with poor patient survival outcomes. CRLF2 B-ALL is five times more prevalent in Hispanic children than others and is associated with a higher rate of relapse, thus contributing …
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Chimeric ANTI-CD19 Monoclonal Antibodies for the Treatment of Precursor B Cell Acute Lymphoblastic Leukemia
Thousands of people are diagnosed with B cell malignancies every year, yet the only FDA-approved immunotherapies for them are based on anti-CD20 monoclonal antibodies (MAbs). However, CD20 is not expressed on precursor B cell acute lymphoblastic leukemia (pre-B ALL), and CD20 expression is often …
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Effects of Pharmacological and Genetic Disruption of Chemokine Receptor Cxcr4 In B-Cell Acute Lymphoblastic Leukemia
… a pivotal role in homing and retention of B-cell Acute Lymphoblastic Leukemia cells to bone marrow niches. The bone marrow stromal cells (BMSCs) constitutively secrete the CXCR4 ligand CXCL12, thus attracting leukemia cells and protecting them from cytotoxic drugs, a mechanism that might be …
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Characterizing The Source of Neutrophil Elastase and Proteinase 3 Cross-Presentation In B-Cell Acute Lymphoblastic Leukemia
… human leukocyte antigen (HLA)-A2 restricted leukemia-associated antigen derived from serine proteases neutrophil elastase (NE) and proteinase 3 (P3). NE and P3 are primarily expressed in cells of myeloid lineage including granulocytes, bone marrow progenitors and myeloid leukemia. Our lab …
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Comparative Studies of TSLP and IL-7 in Normal Early Human Neonatal and Adult B Cell Development
… the role of cytokines in promoting human B cell development is important for understanding B cell leukemia and for developing strategies to restore B cell production that is lost during some therapies. The purpose of this study was to investigate the roles of the IL-7R ligands, thymic …
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In vivo pool-based shRNA screens to identify modulators of disease progression in hematopoietic malignancies
… in identifying novel cancer genes in mammalian cells, but they have primarily been limited to in vitro applications in tumor cell lines. Whereas in vivo retroviral mutagenesis screens typically identify gain-of-function alterations in positive selection screens, shRNA screening approaches allow …
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Investigations on the role of SLP-65 and other B cell signaling proteins in human leukemia
… an adaptor protein preferentially expressed in B cells with a central role in BCR and pre-BCR mediated signal transduction. By providing multiple binding sites for other cellular effector molecules it assembles various proteins into one signaling complex. Therefore SLP-65 is involved in the …
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Co-optation of B Cell Developmental States in Malignancy and Autoimmunity
… a useful lens for understanding the diversity of cell identity and function. Cell state is regulated through both cell-intrinsic and -extrinsic mechanisms, and can diversify through tightly regulated transitions. However, perturbations to these regulatory mechanisms facilitate shifts in cell …
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Análise de Variantes Genéticas no gene da Endoglina em Leucemias Linfoblásticas Agudas de Células B Pediátricas
… ENG expression is reported in blasts in acute lymphoblastic leukemia (ALL) across different studies, and it is identified as a promising complementary diagnostic, prognostic, and therapeutic pathway. Therefore, this study examines the genetic variants rs11545664, rs35400405, and rs786514 …
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Deconvolution of Leukemic Evolution Through Initiation, Progression and Relapse
… in the study of the genomic architecture of B-cell acute lymphoblastic leukemia (B-ALL) have been made, but our understanding of the mechanisms of leukemic initiation and progression remain limited. To gain clarity on these processes, a deeper understanding of the co-operative role of genetic …
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Stimulation of chemotherapy-induced immunity by targeting IL-6 in the tumor microenvironment
… the growth and co-evolution of neoplastic cells in combination with microenvironmental stromal components. Transformed tumor cells initiate crucial changes in healthy tissues that convert their environment into one that supports and furthers cancer development. Consequently, heterogenous …
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Chromatin Architecture Aberrations Contribute and Acute Lymphoblastic Leukemia Relapse
… within the chromatin architecture of cancer cells that includes the genome, molecular modifications to the genome, and the three-dimensional organization of the chromatin fiber. The majority of genetic variants target non-coding regions of the genome and many genes affected by genetic and …
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Functions of Novel Ligand-independent Flt3 Alleles and RANKL in Promoting Dissemination of Murine B-Cell Leukemias to the Central Nervous System
Survival rates for pediatric B-cell acute lymphoblastic leukemia (B-ALL) have improved dramatically, but outcomes for the 15% who relapse and for adults with B-ALL remain poor. Up to 40% of pediatric B-ALL patients require central nervous system (CNS) prophylaxis that causes significant …
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An in vivo RNAi therapy screen identifies novel mediators of leukemia-microenvironment interaction
Minimal residual disease refers to those cancer cells that persist following initial therapy. In precursor B-cell acute lymphoblastic leukemia (BCP-ALL), the presence of minimal residual disease is a strong prognostic indicator of relapse. The establishment of minimal residual disease fundamentally …
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PHF6 is a novel regulator of B-cell identity in acute lymphoblastic leukemia
… PHF6 are seen in approximately 20% of adult T-cell acute lymphoblastic leukemias and 3% of adult acute myeloid leukemias. The notable absence of PHF6 mutations in B-cell lineage malignancies has led to the hypothesis that PHF6 may act as a lineage-specific tumor suppressor gene. Recent work …
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Modeling hematologic malignancies and their treatment in humanized mice
… neoplasms of the hematopoietic system, such as leukemias and lymphomas. Genetically engineered mouse models of these diseases have yielded invaluable insights into the ways normal processes become corrupted, leading to cancer development, progression, and spreading. Yet, as our understanding of …
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Investigating the Role of ZNF384 Rearrangements in Acute Leukemia
… defining lesion in 5% of pediatric and adult B-cell acute lymphoblastic leukemia and tumors are characterized by aberrant myeloid marker expression. Additionally, ZNF384 rearrangements are the defining lesion in nearly half of pediatric B/myeloid mixed phenotype acute leukemia. These fusions …
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Utilizing in vivo genome-wide CRISPR/Cas9 screens in immunocompetent mouse models to identify novel tumor liabilities and explore mechanisms of resistance to Chimeric Antigen Receptor T-cell therapy
… in immunocompetent murine models of GBM or B-cell Acute Lymphoblastic Leukemia (B-ALL). Importantly each screen is the first of its kind with no prior genome-wide screens having been conducted in vivo in an immunocompetent murine model of GBM. The 2 screens conducted in GBM sought to better …