Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 616 for “"B cell"”.
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Targeting the B-Cell Receptor in Diffuse Large B-Cell Lymphoma
Diffuse Large B-Cell Lymphoma (DLBCL) is an aggressive malignancy of which one-third of diagnosed patients ultimately die. New treatment paradigms for relapsedrefractory patients are needed. Almost all DLBCL tumours express a B-cell receptor (BCR), which is a cell surface antigen receptor of …
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The role of Fyn and B-cell expressed ADAM10 in early B cell development, germinal center formation and terminal B cell differentiation
… determine the role of Fyn kinase and ADAM10 in B cell biology. A disintegrin and metalloproteinase 10 (ADAM10) is a zinc dependent proteinase related to matrix metalloproteinases. ADAM10 has emerged as a key regulator of cellular processes by cleaving and shedding extracellular domains of multiple …
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MODULATION OF THE B-CELL REPERTOIRE IN RHEUMATOID ARTHRITIS BY TRANSIENT B-CELL DEPLETION
Although the role of B-cells in autoimmunity is not completely understood, their importance in the pathogenesis of autoimmune diseases has been more appreciated in the past few years. It is now well known that they have roles in addition to (auto) antibody production and are involved by different …
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The Role of Pag1 In The Activated B-Cell Subtype of Diffuse Large B-Cell Lymphoma
<p>Diffuse Large B Cell Lymphoma (DLBCL) is the most common aggressive hematologic malignancy in adults, but despite recent advances in treatment, many patients today still face poor outcomes. Of the two types of DLBCL, activated B-cell (ABC) and germinal center B-cell (GCB), patients diagnosed …
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An alternative B cell development program
Two major types of B cells, the antibody-producing cells of the immune system, are classically distinguished in the spleen: marginal zone (MZ) and follicular (FO). In addition, FO B cells are subdivided into FO I and FO II cells, based on the amount of surface IgM. MZ B cells, which surround the …
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B Cell Receptor Signalng in Germinal Centers
<p>Germinal centers (GC) are sites of B cell clonal expansion, diversification, and antibody affinity selection. This process is limited and directed by T follicular helper cells that provide helper signals to B cells that endocytose, process, and present cognate antigens in proportion to receptor …
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ELUCIDATING REGULATORY NETWORKS PROMOTING B-CELL DEVELOPMENT
B-cells are an essential part of our adaptive immune system. A network of transcription factors together with external signals facilitate the gradual developmental progression from progenitor cells towards the B-cell fate. Several key factors participating in this network have been identified. …
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B cell therapy in ANCA-associated vasculitis
… includes neutrophil activation by B cell-derived ANCAs, activation of the alternative complement pathway, and dysregulated T cell responses that result in a necrotizing vasculitis of small blood vessels. The central role of B cells is highlighted by the presence of activated B cells …
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PI3Kδ in B cell Homeostasis and Transformation
… risk of pulmonary infection, autoimmunity, and B cell lymphoma development. This thesis explores the role of hyperactive PI3Kδ in B cell homeostasis, maintenance, and malignant transformation. The Okkenhaug lab has previously identified a novel mouse model for Diffuse Large B Cell Lymphoma which …
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Translational regulation in aggressive B-cell lymphomas
… (GC) reaction is a dynamic process where B-cells undergo recombination and somatic hypermutation of immunoglobulin genes in response to antigen stimulation. This essential component of the adaptive immune system is associated with cycles of intensive proliferation and selection, which …
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Profiling B cell immune responses by microengraving
… a comprehensive profile of the individual cells involved and the antibodies they produce at a particular point during the immune response. The ability to obtain such detailed "snapshots" describing the immune response with a high level of resolution would have implications for diagnostics …
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Regulation of Protective B cell Anti-Tumor Responses
The role of B cells in tumor progression is complex and often overlooked. Specifically, little is known about the extent to which the specialized populations of innate-like B-1a and B-1b cells participate in and contribute to the anti-tumor immune response. The totality of work presented in this …
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Characterizing B Cell Phenotype During Chronic HCV Infection
… by an attenuation of virus-specific T cell responses. The mechanisms leading to T cell attenuation are still not well understood, and likely involve several integrating correlates. We hypothesized that dysfunctions of antigen presenting cells (APC) may contribute to the immunosuppresed …
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Signals for B cell activation in antibody response
… are the sites where V-gene hypermutation and B cell selection are taking place. Testing specificity and affinity of GC B cell receptor by interaction with antigen on follicular dendritic cells (FDCs) may be an important selection process to select high affinity B cell clone. As antigen on FDC is …
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Early divergent B cell differentiation during antibody responses
The early B cell response to antigen is analyzed, probing the mechanisms of divergent differentiation into plasmablasts or germinal centre (GC) B cells. Heterozygous QMxB6 mice, in which 5% of B cells are specific for the hapten 4-hydroxy-3-nitrophenol (NP), were immunized with NP-Ficoll. Varying …
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Elucidating oncogenic mechanisms in human B cell malignancies
… Leukaemia (ALL) and Diffuse Large B Cell Lymphoma (DLBCL). Firstly, Pre-B ALL represents the most common paediatric malignancy and despite increasingly improved outcomes for patients, ~ 20% of all patients diagnosed with ALL relapse. Activating mutations in the RAS pathway are common …
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B-Cell Epitope Prediction for Improved Antibody Docking
… docking models, we propose to first train a B-Cell epitope predictor and to subsequently use it to produce a diverse set of candidate binding sites. Our epitope predictor achieves state of the art performance, with an ROC-AUC score of 76. We then show that, by properly post-processing the …
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