Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"B and T Lymphocyte Attenuator"”.
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Mechanistic and Functional Characterization of B and T Lymphocyte Attenuator (Btla) In Cd8 Tumor Infiltrating Lymphocytes
<p>This dissertation project focused on understanding the functional role of BTLA on CD8<sup>+</sup> Tumor Infiltrating Lymphocytes (TIL) from metastatic melanoma patients. Clinical trials of adoptive T-cell therapy (ACT) using autologous <em>ex vivo </em>expanded TIL have demonstrated the great …
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Immunosenescence in B Cells: A Study on Changes in Immunoregulator Expression and Metabolism With Age
… for better vaccines for the aging population, and especially better vaccines to influenza viruses. To address this, I studied immunosenescence in B cells and antibody secreting cells (ASCs) in mice and humans. In humans, I measured humoral immune responses to the trivalent inactivated influenza …
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Characterization of Differentiation and Prognostic Biomarkers On Cd8+ Tumor-Infiltrating Lymphocytes In Metastatic Melanoma
<p>CD8<sup>+</sup> cytotoxic T lymphocytes (CTL) frequently infiltrate tumors, yet most melanoma patients fail to undergo tumor regression. We studied the differentiation of the CD8<sup>+</sup> tumor-infiltrating lymphocytes (TIL) from 44 metastatic melanoma patients using known T-cell …