Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"B Cell Differentiation"”.
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Early divergent B cell differentiation during antibody responses
The early B cell response to antigen is analyzed, probing the mechanisms of divergent differentiation into plasmablasts or germinal centre (GC) B cells. Heterozygous QMxB6 mice, in which 5% of B cells are specific for the hapten 4-hydroxy-3-nitrophenol (NP), were immunized with NP-Ficoll. Varying …
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Early Growth Response Protein 2 (EGR2) regulation of B cell differentiation in lupus-prone mice
… treatment. It involves abnormal activation of B cells, which produce pathogenic autoantibodies that contribute to inflammation and tissue damage in multiple organs. Therapeutic depletion of B cells in human lupus patients had mixed success due to the complex heterogeneity of B cell subsets, …
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Genetic screens of RNA binding proteins identify a role for N6-methyladenosine in promoting B cell differentiation
… identify roles for RBPs in redox signalling, B cell lymphomagenesis, CD8 T cell activation, and B cell terminal differentiation. These identified over a dozen potential avenues of future investigation into the roles of RBPs in lymphocytes. I chose to further investigate the role of the RNA …
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The role of Fyn and B-cell expressed ADAM10 in early B cell development, germinal center formation and terminal B cell differentiation
… determine the role of Fyn kinase and ADAM10 in B cell biology. A disintegrin and metalloproteinase 10 (ADAM10) is a zinc dependent proteinase related to matrix metalloproteinases. ADAM10 has emerged as a key regulator of cellular processes by cleaving and shedding extracellular domains of multiple …
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CATALYTIC-INDEPENDENT FUNCTIONS OF KDM6A IN B CELL MATURATION AND IMMUNE REGULATION
… transcriptional activation of genes that control cell differentiation during embryonic development and postnatal life. It is recurrently mutated in several solid and hematological cancers and is responsible for Kabuki syndrome. While Kdm6a has been extensively studied in early hematopoiesis, …
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Development of a human plasmacytoma cell line with inducible expression of activated B-cell factor-1
… basic helix-loop-helix protein, activated B-cell factor-l (ABF-l), is a transcription factor involved in cellular proliferation and differentiation. ABF-1 shows patterns of expression that are stimulated in activated B cells, which may suggest ABF-1 is involved in the regulation of B-cell …
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Detection of glial interleukin-6 release: Development of a novel interleukin-6 Elisa
… study. IL-6 is a cytokine known to stimulate B-cell differentiation and to activate T-cells. IL-6 is elevated in inflammatory and neurodegenerative diseases. Interleukin-1beta (IL-1beta) stimulates IL-6 release from glial cells. Catecholamines and IL-1beta synergistically release IL-6 from glial …
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Isoform-Selective HDAC Inhibition for the Treatment of Lupus Nephritis
… has yet to be determined, both B and T cell dysregulation are thought to contribute to disease. Histone deacetylases (HDACs) are a class of enzymes that hydrolyze the lysine bound acetyl group in both histone and non-histone proteins thereby altering protein structure and function. While …
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Downregulation of Prdm16 Is Critical for HOXB4-mediated Benign HSC Expansion In Vivo
<p>Overexpression of HOXB4 in hematopoietic stem cells (HSCs) leads to increased self-renewal without causing hematopoietic malignancies in transplanted mice. The molecular basis of HOXB4-mediated benign HSC expansion in vivo is not well understood. To gain further insight into the molecular events …
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Mapping of the repression domain and the subcellular localization of the ABF-1 protein
… pancreas and heart. A recently discovered B-cell restricted bHLH transcription factor activated Bcell factor 1 (ABF -1) is suspected to play a role in the regulation of B cell differentiation. ABF -1 was initially characterized as being a transcriptional repressor because it was able to …
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Cellular requirements for antibody production in a novel LPS-enhanced model of autoimmune myasthenia gravis
Bacterial lipopolysaccharide (LPS) is a T cell-independent adjuvant known to abrogate peripheral tolerance. For the first time, the potential of LPS to induce antigenspecific B cell responses to acetylcholine receptor (AChR) in myasthenia gravis (MG) was evaluated in wild type (WT), CD4-/-, and …
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Investigations on the role of SLP-65 and other B cell signaling proteins in human leukemia
… an adaptor protein preferentially expressed in B cells with a central role in BCR and pre-BCR mediated signal transduction. By providing multiple binding sites for other cellular effector molecules it assembles various proteins into one signaling complex. Therefore SLP-65 is involved in the …
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Immunological markers in hairy-cell leukaemia
… of a previously unrecognised marker in hairy-cell leukaemia (HCL), a receptor for IgM. The rosette method used to reveal this receptor, and the conditions affecting rosette formation are described. A kinetic study of this receptor is used to provide a measure of membrane turnover in HCL. The …
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Identification and characterization of genes expressed by the midbrain dopaminergic neurons
… intermediate period between induction and full differentiation of the mDA neurons. The generation of En chimeric animals permitted to show that the mDA neurons require the Engrailed (En) genes cell autonomously for their survival, and the over-expression experiment of En-1 suggested that the En …
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Identification and evaluation of Limosilactobacillus reuteri as an inducer of neonatal IgA and autoimmunity
… 6475 has the antigenic ability to stimulate B cell differentiation and IgA production, but it is suppressed by a mechanism related to differences in surface architecture of this strain. L. reuteri strains also vary in their potency of aryl hydrocarbon receptor (AhR) stimulation. In mice, …
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C-Rel Is A Transcriptional Target of Mesoderm Inducer In Xenopus Like 1 (Mixl1)
… crisis, AML (Acute myelogenous leukemia), B cell lymphomas and pediatric ALL (Acute lymphocytic leukemia). (ii) Retroviral transduction of Mixl1 induces AML in murine models. Nonetheless, mechanisms underlying MIXL1 mediated proliferative, survival advantages are unknown.</p> <p>The goal of …
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Ldoc1, A Novel Biomarker of Prognosis In Chronic Lymphocytic Leukemia
… variable region (IGHV) genes. Patients whose CLL cells have unmutated IGHV genes have a median survival of 8 years; those with mutated IGHV genes have a median survival of 25 years. To identify new prognostic biomarkers and molecular targets for therapy in untreated CLL patients, we reanalyzed the …
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Regulation of the germinal center reaction by T helper cells and T regulatory cells
… that arise in lymphoid organs in response to T cell-dependent antigen. Within the GC, follicular T helper (TFH) cells promote GC B cell differentiation and in turn the proper antibody production to protect us from invading pathogens. We wished to study the regulation of this process by …
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INVESTIGATING IMMUNE SYSTEM REGULATION THROUGH CROSS-DISEASE GENETIC ANALYSIS AND B CELL FATE DECISIONS
… altering the same immune-mediated pathways in T cells. I found evidence that showed the causal role of 46 genes in predisposing to the three disease groups; eight of these genes are already targeted by treatments in autoimmunity and could be exploited for drug repurposing. Supporting preclinical …
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