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Showing 1 to 6 of 6 for “"B형간염"”.

  1. AMP-activated protein kinase-mTOR signaling pathway and hepatitis B virus replication

    B형간염 바이러스(hepatitis B virus, HBV)는 Hepadnaviridae family에 속하며, genome 크기가 약 3.2kb의 작은 DNA 바이러스이다. 전 세계적으로 약 3억 5천만 명 이상이 만성으로 HBV에 감염되어 있다. HBV는 급성과 만성 B형 간염을 일으키며 만성 B형 간염 환자는 간경변이나 간암으로 발전할 가능성이 높다. AMP-activated protein kinase(AMPK)는 ATP 소비와 생성의 균형을 위해서 필요한 에너지 센서 단백질이다. Hepatitis C virus(HCV)의 …

    ajou Repository record for AMP-activated protein kinase-mTOR signaling pathway and hepatitis B virus replication (opens in a new tab)

  2. Analysis of Treatment Effect of Lamivudine plus Adefovir Add-on Therapy in Patients with Lamivudine Resistant Chronic B-viral Hepatitis

    목적: 라미부딘은 만성 B형 간염의 1차 치료제로 널리 사용되어 왔으나 내성 발현이 잦은 단점이 있다. 이러한 단점을 극복하기 위해 아데포비어 병합 치료가 사용되고 있으나 한국인을 대상으로 한 연구 결과는 적은 편이다. 저자들은 라미부딘에 내성인 B형 만성 간염 환자를 대상으로 라미부딘과 아데포비어 병합 치료 효과와 바이러스 돌파 현상을 확인하고자 하였다. 방법: 2005년 8월부터 2010년 10월까지 본원에서 라미부딘 투여 중 내성이 발생한 후 아데포비어를 추가??여 치료한 환자 중 12개월 이상 치료받은 93명을 대상으로 …

    ajou Repository record for Analysis of Treatment Effect of Lamivudine plus Adefovir Add-on Therapy in Patients with Lamivudine Resistant Chronic B-viral Hepatitis (opens in a new tab)

  3. Comparison of Serum HBV DNA Levels between Lamivudine Induced HBeAg Seroconversion and Spontaneous Seroconversion

    PURPOSE: It has been suggested that the cumulative relapse rate in patients with spontaneous HBeAg seroconversion is usually lower than the rate in patients with lamivudine induced HBeAg seroconversion in Asians with chronic hepatitis B. The aim of this study was to compare serum HBV DNA levels at …

    ajou Repository record for Comparison of Serum HBV DNA Levels between Lamivudine Induced HBeAg Seroconversion and Spontaneous Seroconversion (opens in a new tab)

  4. Association of HBV DNA and ALT Level with YMDD motif Mutation Type in Lamivudine Resistance for Chronic Hepatitis B

    BACKGROUND: The emergence of lamivudine resistant hepatitis B virus(HBV), with point mutation in the YMDD motif of DNA polymerase gene, has been reported in chronic hepatitis B patients with lamivudine treatment. The aim of this study was to investigate the distribution patterns and clinical …

    ajou Repository record for Association of HBV DNA and ALT Level with YMDD motif Mutation Type in Lamivudine Resistance for Chronic Hepatitis B (opens in a new tab)

  5. Inter-alpha-trypsin inhibitor heavy chain H4 as a diagnostic and prognostic indicator in patients with hepatitis B virus-associated hepatocellular carcinoma

    OBJECTIVES: Inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) is associated with various diseases. We evaluated the diagnostic and prognostic significance of serum ITIH4 levels in healthy controls and patients with chronic hepatitis B (CHB), hepatitis B virus (HBV)-related liver cirrhosis, and …

    ajou Repository record for Inter-alpha-trypsin inhibitor heavy chain H4 as a diagnostic and prognostic indicator in patients with hepatitis B virus-associated hepatocellular carcinoma (opens in a new tab)

  6. Multidrug-Resistant Hepatitis B Virus Resulting From Sequential Monotherapy With Lamivudine, Adefovir, and Entecavir: Clonal Evolution During Lamivudine Plus Adefovir Therapy

    BACKGROUND & AIMS: Whether multidrug-resistant (MDR) hepatitis B virus (HBV) harbors mutations co-located in the same HBV clones that confer reduced sensitivity to antiviral therapy remains uncertain. This study investigated the evolution of MDR HBV strains developed from sequential monotherapy …

    ajou Repository record for Multidrug-Resistant Hepatitis B Virus Resulting From Sequential Monotherapy With Lamivudine, Adefovir, and Entecavir: Clonal Evolution During Lamivudine Plus Adefovir Therapy (opens in a new tab)