Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Azole resistance"”.
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ERG11-Mediated Azole Resistance in Candida albicans
… and empirical treatment strategies. Antifungal resistance is associated with high mortality rates and hefty medical costs. The azole-antifungal class has been the “work horse” of antifungal pharmacotherapy for the past 20 years defined by its efficacy against <em>Candida</em> species and paucity …
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New Challenges in Azole Resistance Selection in Aspergillus fumigatus
Contains fulltext : 327953.pdf (Publisher’s version ) (Closed access)
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An Investigation into Clinically Relevant Determinants of Azole Resistance in Candida albicans
… healthcare system. Over the last 30 years, the azole antifungals have been a mainstay of antifungal therapy, being effective in a wide variety of fungal infections and serving as the primary oral treatment option. However, increased use, inappropriate dosing, and prolonged treatments have given …
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Signal Transduction and Transcriptional Regulation Pathways Essential for Azole Resistance in Candida albicans
… with human immunodeficiency virus (HIV). The azole antifungals (such as fluconazole) are the most widely used and important ergosterol biosynthesis inhibitors (EBIs) for the treatment of Candida infections, including OPC. However, the azoles are fungistatic against C. albicans and therefore …
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The role of adaptive mechanisms in the development of azole resistance in Aspergillus fumigatus
Contains fulltext : 293024.pdf (Publisher’s version ) (Open Access)
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Transcriptional Regulation of Azole Antifungal Resistance in Candida albicans
… virus (HIV). OPC is usually treated with azole antifungals, a class of antifungals that target ergosterol biosynthesis, at low doses over long periods of time. This course of treatment allows for the development of azole resistance.</p> <p>Two major mechanisms of azole resistance exist in …
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Transcriptional Regulation of Azole Antifungal Resistance and Tolerance in Candida Glabrata
<p>Azole antifungal resistance has emerged as a significant problem in the management of infections caused by fungi including <em>Candida</em> species. In recent years, <em>Candida glabrata</em> has become the second most common cause of mucosal and invasive fungal infections in humans second to …
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The Molecular Mechanisms of Antifungal Drug Resistance In Pathogenic Fungi
… mostly in immune-compromised individuals. Azoles are the most common antifungals used in treating these infections. The most significant mechanisms of azole resistance include alterations or overexpression of the target enzyme, and overexpression of at least three distinct efflux pumps. …
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Novel Determinants That Influence Azole Susceptibility in Candida glabrata and Candida albicans
… </em>infections, expresses high rates of resistance to treatment with arguably the best class of currently available antifungals - the azoles.</p> <p>Other available antifungals have associated toxicities, are not available as oral dosage forms or are cost prohibitive. As multidrug …
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Probing the role of histone acetylation in the evolution of pathogenicity in <i>Candida glabrata</i>
… due to the former’s intrinsic antifungal resistance. <i>C. glabrata </i>also possesses a particularly interesting phylogeny, being a pathogen that is closely related to the non-pathogenic yeast <i>S. cerevisiae</i>. This makes <i>C. glabrata</i> a valuable model species to investigate …
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Diagnostic characterization of Malassezia pachydermatis isolates from canine otitis externa
… that treating M. pachydermatis OE with miconazole was no longer successful in a number of cases. This finding raised the question of whether the treatment failure was due to intrinsic resistance of a cryptic species or if azole resistance was emerging in M. pachydermatis clinical isolates. To …
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FUSARIUM MUSAE AND FUSARIUM VERTICILLIOIDES CROSS-KINGDOM PATHOGENS: GENOMICS AND DIAGNOSTIC INNOVATION
… isolates. Moreover, the widespread use of azole antifungals in both agricultural and clinical settings has further intensified this concern, as the shared modes of action of these compounds contribute to the emergence of resistant strains and may facilitate cross-environment adaptation. …
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Endosomal Trafficking as a Determinant of Antifungal Tolerance in the Pathogenic Fungus Candida albicans
… of fungal cell membranes. These include the azole antifungals, which block ergosterol biosynthesis by inhibiting lanosterol demethylase (Erg11p). The resulting depletion of cellular ergosterol and the accumulation of ‘toxic’ sterol intermediates are both thought to cause plasma membrane …
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Developing novel drug combinations for treatment of invasive fungal infections
… are restricted to three classes of antifungals: Azoles, polyenes, and echinocandins. The emergence of new fungal species, especially C. auris, marked by high resistance profiles and increased mortality rates (30-60%), has further exacerbated the limitations in its therapeutic options. This …
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Delineating the Upc2A Regulon in Candida glabrata
… common cause of invasive candidiasis. Intrinsic resistance has greatly limited the utility of the triazole antifungal, fluconazole, in the treatment of invasive fungal infection. The transcription factor Upc2 regulates the expression of sterol biosynthesis genes in yeast. Disrupting UPC2A in C. …